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Biomolecules, Volume 13, Issue 3
March 2023 - 176 articles
Cover Story: The actin cytoskeleton is involved in many cellular processes, including cell migration, adhesion, invasion, endo- and phagocytosis, and division. Actin bundles are the main constituent of actin-rich structures involved in these processes. Recent advances in high-resolution techniques pave the way to a better understanding of physiological bundles formation. Here, we overview the physical and biochemical properties of four families of highly conserved and abundant actin-bundling proteins, namely α-actinin, fimbrin/plastin, fascin, and espin. We describe their role in forming physiological actin bundles and the properties they bestow—both related and unrelated to their bundling abilities. We also review some aspects of the general mechanism of actin bundle formation. View this paper
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