Relationship between Brain-Derived Neurotrophic Factor and Cognitive Decline in Patients with Mild Cognitive Impairment and Dementia
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants
2.2. Blood Sample Collection
2.3. Measurement of Plasma BDNF Concentration
2.4. Statistical Analysis
3. Results
3.1. Participants
3.2. Plasma BDNF Concentration in MCI Subjects and AD Patients
3.3. Plasma BDNF Concentrations and Cognitive Decline
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Participants | Mann–Whitney U Test | |||
---|---|---|---|---|
MCI | AD | U | p | |
Age (years) | 71.0 (41.0–88.0) | 77.5 (49–94) | 32,536.5 | <0.001 |
BMI (kg/m2) | 22.0 (18.4–32.4) | 23.4 (18.5–31.9) | 6935.5 | 0.354 |
Waist circumference (cm) | 86.0 (71.0–101.0) | 86.0 (72.0–99.0) | 6459.0 | 0.986 |
Total cholesterol (mmol/L) | 5.4 (3.2–8.8) | 5.7 (3.2–8.8) | 6759.0 | 0.566 |
HDL-cholesterol (mmol/L) | 1.3 (0.7–3.0) | 1.3 (0.7–3.0) | 6397.0 | 0.888 |
LDL-cholesterol (mmol/L) | 3.1 (0.8–5.6) | 3.3 (0.8–5.8) | 7016.0 | 0.278 |
Triglycerides | 1.8 (0.7–6.7) | 1.8 (0.7–6.7) | 6756.0 | 0.569 |
Blood glucose (mmol/L) | 5.5 (4.4–11.8) | 5.6 (4.7–11.8) | 7191.5 | 0.153 |
MMSE score | 27.0 (21.0–30.0) | 16.5 (0.0–27.0) | 1535.5 | <0.001 |
CDT score | 5.0 (0.0–5.0) | 1.0 (0.0–5.0) | 7129.0 | <0.001 |
Characteristics | MCI | AD | ||
---|---|---|---|---|
rs | p | rs | p | |
Age (years) | −0.135 | 0.057 | 0.126 | 0.057 |
BMI (kg/m2) | 0.011 | 0.891 | 0.055 | 0.618 |
Waist circumference (cm) | 0.009 | 0.910 | 0.071 | 0.523 |
Total cholesterol (mmol/l) | −0.037 | 0.646 | −0.151 | 0.170 |
HDL-cholesterol (mmol/l) | −0.083 | 0.308 | −0.092 | 0.406 |
LDL-cholesterol (mmol/l) | −0.040 | 0.624 | −0.088 | 0.427 |
Triglycerides | 0.024 | 0.764 | 0.021 | 0.850 |
Blood glucose (mmol/l) | −0.024 | 0.765 | 0.204 | 0.063 |
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Nikolac Perkovic, M.; Borovecki, F.; Filipcic, I.; Vuic, B.; Milos, T.; Nedic Erjavec, G.; Konjevod, M.; Tudor, L.; Mimica, N.; Uzun, S.; et al. Relationship between Brain-Derived Neurotrophic Factor and Cognitive Decline in Patients with Mild Cognitive Impairment and Dementia. Biomolecules 2023, 13, 570. https://doi.org/10.3390/biom13030570
Nikolac Perkovic M, Borovecki F, Filipcic I, Vuic B, Milos T, Nedic Erjavec G, Konjevod M, Tudor L, Mimica N, Uzun S, et al. Relationship between Brain-Derived Neurotrophic Factor and Cognitive Decline in Patients with Mild Cognitive Impairment and Dementia. Biomolecules. 2023; 13(3):570. https://doi.org/10.3390/biom13030570
Chicago/Turabian StyleNikolac Perkovic, Matea, Fran Borovecki, Igor Filipcic, Barbara Vuic, Tina Milos, Gordana Nedic Erjavec, Marcela Konjevod, Lucija Tudor, Ninoslav Mimica, Suzana Uzun, and et al. 2023. "Relationship between Brain-Derived Neurotrophic Factor and Cognitive Decline in Patients with Mild Cognitive Impairment and Dementia" Biomolecules 13, no. 3: 570. https://doi.org/10.3390/biom13030570