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Biomolecules, Volume 9, Issue 9 (September 2019)
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Cover Story (view full-size image) We have shown that poly(phosphorhydrazone) (PPH) dendrimers of the first generation capped with [...] Read more. We have shown that poly(phosphorhydrazone) (PPH) dendrimers of the first generation capped with azabisphosphonate (ABP) groups have anti-inflammatory properties towards several subpopulations of human immune cells in vitro. In particular, the PPH dendrimer capped with twelve ABP surface groups has exhibited a strong efficacy in animal models of both chronic and acute inflammatory disorders. In the process of clinical development of this drug-candidate, we have designed and synthesized bioactive fluorescent analogs to study the bio-distribution of this family of molecules. One of these analogs shows fluorescence emission in near infra-red wavelengths, with no overlap of tissue auto-fluorescence, therefore, enabling in vivo quantification. View this paper.