Biomolecules, Volume 9, Issue 9 (September 2019) – 120 articles
Cover Story (view full-size image):
We have shown that poly(phosphorhydrazone) (PPH) dendrimers of the first generation capped with azabisphosphonate (ABP) groups have anti-inflammatory properties towards several subpopulations of human immune cells in vitro. In particular, the PPH dendrimer capped with twelve ABP surface groups has exhibited a strong efficacy in animal models of both chronic and acute inflammatory disorders. In the process of clinical development of this drug-candidate, we have designed and synthesized bioactive fluorescent analogs to study the bio-distribution of this family of molecules. One of these analogs shows fluorescence emission in near infra-red wavelengths, with no overlap of tissue auto-fluorescence, therefore, enabling in vivo quantification. View this paper.
- Issues are regarded as officially published after their release is announced to the table of contents alert mailing list.
- You may sign up for e-mail alerts to receive table of contents of newly released issues.
- PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader
to open them.
Previous Issue
Next Issue