Table of Contents
Biomolecules, Volume 9, Issue 4 (April 2019)
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Cover Story (view full-size image) Genome integrity is essential for proper development and viability. dUTPase (the protein product of [...] Read more. Genome integrity is essential for proper development and viability. dUTPase (the protein product of the dut gene) plays a key role in preserving DNA by removing dUTP from the cellular pool and contributes to dTTP de novo biosynthesis (by producing the dUMP substrate for thymidylate synthase (TS)). CRISPR/Cas9 transgenic mouse studies provided major insights into the physiological role of dUTPase in mammalian embryonic development. Biallelic dUTPase knock-out (dut -/-) embryos were still viable at the blastocyst stage but died shortly after implantation. Wild type and heterozygote animals showed the same healthy phenotype. Results suggest that zygotic dUTPase may be dispensable for pre-implantation embryonic stages but the lack of the enzyme lethally perturbs later embryonic development. View this paper.