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Mouse Models for Exploring the Biological Consequences and Clinical Significance of PIK3CA Mutations

1
Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia
2
Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia
*
Author to whom correspondence should be addressed.
Biomolecules 2019, 9(4), 158; https://doi.org/10.3390/biom9040158
Received: 29 March 2019 / Revised: 18 April 2019 / Accepted: 19 April 2019 / Published: 23 April 2019
(This article belongs to the Special Issue Phosphoinositide 3-kinase, a Field in Transition)
The phosphatidylinositol 3-kinase (PI3K) pathway is involved in a myriad of cellular signalling pathways that regulate cell growth, metabolism, proliferation and survival. As a result, alterations in the PI3K pathway are frequently associated with human cancers. Indeed, PIK3CA—the gene encoding the p110α catalytic subunit of PI3K—is one of the most commonly mutated human oncogenes. PIK3CA mutations have also been implicated in non-malignant conditions including congenital overgrowth syndromes and vascular malformations. In order to study the role of PIK3CA mutations in driving tumorigenesis and tissue overgrowth and to test potential therapeutic interventions for these conditions, model systems are essential. In this review we discuss the various mouse models currently available for preclinical studies into the biological consequences and clinical significance of PIK3CA mutations. View Full-Text
Keywords: PI3K; PI 3-kinase; PIK3CA; mouse model; knock-in; transgenic; cancer; overgrowth; PROS PI3K; PI 3-kinase; PIK3CA; mouse model; knock-in; transgenic; cancer; overgrowth; PROS
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MDPI and ACS Style

Mitchell, C.B.; Phillips, W.A. Mouse Models for Exploring the Biological Consequences and Clinical Significance of PIK3CA Mutations. Biomolecules 2019, 9, 158.

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