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Biomolecules, Volume 9, Issue 11

November 2019 - 112 articles

Cover Story: Plaques consisting of amyloid-β (Aβ) are a major pathological hallmark of Alzheimer´s disease. Aβ is derived by amyloidogenic APP processing and prevented by a non-amyloidogenic pathway. Methylxanthines like caffeine decrease Aβ levels by shifting APP processing to the non-amyloidogenic pathway by decreasing β- and increasing α-secretase activity. Other factors that are also in involved in neurodegenerative diseases, like cholesterol, reactive oxygen species, APP expression, and Aβ aggregation, were also positively affected. Similar mechanisms were observed for all analyzed methylxanthines. Although effect strengths were moderate, the integration of methylxanthines as part of a healthy diet should be considered, especially because of their cost effectiveness, availability, and modest side effects. View this paper.
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Articles (112)

  • Article
  • Open Access
57 Citations
6,186 Views
14 Pages

CRISPR/Cas9-Mediated Multiplex Genome Editing of JAGGED Gene in Brassica napus L.

  • Qamar U Zaman,
  • Wen Chu,
  • Mengyu Hao,
  • Yuqin Shi,
  • Mengdan Sun,
  • Shi-Fei Sang,
  • Desheng Mei,
  • Hongtao Cheng,
  • Jia Liu and
  • Chao Li
  • + 1 author

12 November 2019

Pod shattering resistance is an essential component to achieving a high yield, which is a substantial objective in polyploid rapeseed cultivation. Previous studies have suggested that the Arabidopsis JAGGED (JAG) gene is a key factor implicated in th...

  • Review
  • Open Access
33 Citations
8,387 Views
17 Pages

Viral Infections and Interferons in the Development of Obesity

  • Yun Tian,
  • Jordan Jennings,
  • Yuanying Gong and
  • Yongming Sang

12 November 2019

Obesity is now a prevalent disease worldwide and has a multi-factorial etiology. Several viruses or virus-like agents including members of adenoviridae, herpesviridae, slow virus (prion), and hepatitides, have been associated with obesity; meanwhile...

  • Article
  • Open Access
17 Citations
5,460 Views
17 Pages

12 November 2019

Low-density lipoprotein (LDL) and high-density lipoprotein (HDL) oxidation are well known to increase the risk for atherosclerosis. In our ongoing research on natural products with inhibitory activities against oxidation of lipoproteins, fruits of Vi...

  • Article
  • Open Access
20 Citations
5,693 Views
17 Pages

12 November 2019

Human NAD(P)H:quinone oxidoreductase 1 (NQO1) is a multi-functional protein whose alteration is associated with cancer, Parkinson’s and Alzheimer´s diseases. NQO1 displays a remarkable functional chemistry, capable of binding different fu...

  • Article
  • Open Access
11 Citations
3,456 Views
21 Pages

The Effect of Transmembrane Protein Shape on Surrounding Lipid Domain Formation by Wetting

  • Rodion J. Molotkovsky,
  • Timur R. Galimzyanov,
  • Oleg V. Batishchev and
  • Sergey A. Akimov

12 November 2019

Signal transduction through cellular membranes requires the highly specific and coordinated work of specialized proteins. Proper functioning of these proteins is provided by an interplay between them and the lipid environment. Liquid-ordered lipid do...

  • Article
  • Open Access
77 Citations
6,130 Views
12 Pages

Characterization and Antioxidant Activity of a Low-Molecular-Weight Xanthan Gum

  • Xiaolong Hu,
  • Kangli Wang,
  • Miao Yu,
  • Peixin He,
  • Hanzhen Qiao,
  • Huiru Zhang and
  • Zichao Wang

12 November 2019

In the present work, a low-molecular-weight xanthan gum (LW-XG) was successfully obtained via biodegradation of commercial xanthan by the endophytic fungus Chaetomium globosum CGMCC 6882. The monosaccharide composition of LW-XG was glucose, mannose,...

  • Review
  • Open Access
72 Citations
8,771 Views
38 Pages

12 November 2019

Luteolin is a flavonoid often found in various medicinal plants that exhibits multiple biological effects such as antioxidant, anti-inflammatory and immunomodulatory activity. Commercially available medicinal plants and their preparations containing...

  • Article
  • Open Access
10 Citations
4,859 Views
28 Pages

The Novel Serine/Threonine Protein Kinase LmjF.22.0810 from Leishmania major May Be Involved in the Resistance to Drugs such as Paromomycin

  • Andrés Vacas,
  • Celia Fernández-Rubio,
  • Miriam Algarabel,
  • José Peña-Guerrero,
  • Esther Larrea,
  • Fabio Rocha Formiga,
  • Alfonso T. García-Sosa and
  • Paul A. Nguewa

11 November 2019

The identification and clarification of the mechanisms of action of drugs used against leishmaniasis may improve their administration regimens and prevent the development of resistant strains. Herein, for the first time, we describe the structure of...

  • Feature Paper
  • Article
  • Open Access
10 Citations
4,746 Views
14 Pages

Mutation S115T in IMP-Type Metallo-β-Lactamases Compensates for Decreased Expression Levels Caused by Mutation S119G

  • Charles J. Zhang,
  • Mohammad Faheem,
  • Paulie Dang,
  • Monica N. Morris,
  • Pooja Kumar and
  • Peter Oelschlaeger

11 November 2019

(1) Background: Metallo-β-lactamases (MBLs) have raised concerns due to their ability to inactivate carbapenems and newer generation cephalosporins and the absence of clinically available MBL inhibitors. Their genes are often transferred horizon...

  • Article
  • Open Access
9 Citations
4,389 Views
18 Pages

10 November 2019

Advanced glycation end products (AGEs), which are present in heat-processed foods, have been associated with several chronic diseases. Sodium chloride (NaCl) modulates the formation of furfurals and acrylamide in the Maillard reaction; however, the e...

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Biomolecules - ISSN 2218-273X