Next Article in Journal
Characterization and Antioxidant Activity of a Low-Molecular-Weight Xanthan Gum
Next Article in Special Issue
Structural Lesions of Proteins Connected to Lipid Membrane Damages Caused by Radical Stress: Assessment by Biomimetic Systems and Raman Spectroscopy
Previous Article in Journal
A Dynamic Core in Human NQO1 Controls the Functional and Stability Effects of Ligand Binding and Their Communication across the Enzyme Dimer
Previous Article in Special Issue
Coupled Response of Membrane Hydration with Oscillating Metabolism in Live Cells: An Alternative Way to Modulate Structural Aspects of Biological Membranes?
Open AccessArticle

The Effect of Transmembrane Protein Shape on Surrounding Lipid Domain Formation by Wetting

A.N. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, 31/4 Leninskiy Prospekt, 119071 Moscow, Russia
Department of Theoretical Physics and Quantum Technologies, National University of Science and Technology “MISiS”, 4 Leninskiy Prospect, 119049 Moscow, Russia
Moscow Institute of Physics and Technology, 9 Institutskiy Lane, Dolgoprudniy, 141700 Moscow Region, Russia
Author to whom correspondence should be addressed.
Biomolecules 2019, 9(11), 729;
Received: 5 October 2019 / Revised: 9 November 2019 / Accepted: 11 November 2019 / Published: 12 November 2019
Signal transduction through cellular membranes requires the highly specific and coordinated work of specialized proteins. Proper functioning of these proteins is provided by an interplay between them and the lipid environment. Liquid-ordered lipid domains are believed to be important players here, however, it is still unclear whether conditions for a phase separation required for lipid domain formation exist in cellular membranes. Moreover, membrane leaflets are compositionally asymmetric, that could be an obstacle for the formation of symmetric domains spanning the lipid bilayer. We theoretically show that the presence of protein in the membrane leads to the formation of a stable liquid-ordered lipid phase around it by the mechanism of protein wetting by lipids, even in the absence of conditions necessary for the global phase separation in the membrane. Moreover, we show that protein shape plays a crucial role in this process, and protein conformational rearrangement can lead to changes in the size and characteristics of surrounding lipid domains. View Full-Text
Keywords: liquid-ordered domain; wetting; theory of elasticity; transmembrane protein liquid-ordered domain; wetting; theory of elasticity; transmembrane protein
Show Figures

Figure 1

MDPI and ACS Style

Molotkovsky, R.J.; Galimzyanov, T.R.; Batishchev, O.V.; Akimov, S.A. The Effect of Transmembrane Protein Shape on Surrounding Lipid Domain Formation by Wetting. Biomolecules 2019, 9, 729.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop