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Biomolecules, Volume 14, Issue 3

March 2024 - 139 articles

Cover Story: Orphan nuclear receptor 4A1 (NR4A1, Nur77) and NR4A2 (Nurr1) are pro-oncogenic factors in solid tumors. A recent study reported that a series of 1,1-bis(3′-indoly)-1-(3,5-disubstitutedphenyl)methane (DIM-3,5) analogs were potent inhibitors of mammary tumor growth in a mouse xenograft model. The potency of these compounds coupled with >60% similarity of the ligand binding domains of NR4A1 and NR4A2 suggested that DIM-3,5 compounds may also bind and activate NR4A2. This study demonstrates that DIM-3,5 analogs bind both receptors as novel dual NR4A1/NR4A2 ligands that act as inverse NR4A1/2 agonists in cancer cell lines. These compounds will be used to target tumors and tumor-infiltrating lymphocytes. View this paper
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Articles (139)

  • Article
  • Open Access
7 Citations
2,839 Views
14 Pages

Enzymes with Lactonase Activity against Fungal Quorum Molecules as Effective Antifungals

  • Elena Efremenko,
  • Aysel Aslanli,
  • Maksim Domnin,
  • Nikolay Stepanov and
  • Olga Senko

21 March 2024

Since the growing number of fungi resistant to the fungicides used is becoming a serious threat to human health, animals, and crops, there is a need to find other effective approaches in the eco-friendly suppression of fungal growth. One of the main...

  • Article
  • Open Access
1 Citations
3,133 Views
16 Pages

Molecular Profiling of Axial Spondyloarthritis Patients Reveals an Association between Innate and Adaptive Cell Populations and Therapeutic Response to Tumor Necrosis Factor Inhibitors

  • Daniel Sobral,
  • Ana Filipa Fernandes,
  • Miguel Bernardes,
  • Patrícia Pinto,
  • Helena Santos,
  • João Lagoas-Gomes,
  • José Tavares-Costa,
  • José A. P. Silva,
  • João Madruga Dias and
  • Alexandra Bernardo
  • + 8 authors

21 March 2024

This study aims at identifying molecular biomarkers differentiating responders and non-responders to treatment with Tumor Necrosis Factor inhibitors (TNFi) among patients with axial spondyloarthritis (axSpA). Whole blood mRNA and plasma proteins were...

  • Review
  • Open Access
11 Citations
5,186 Views
17 Pages

Dissecting the Roles of the Cytokinin Signaling Network: The Case of De Novo Shoot Apical Meristem Formation

  • Nina Pokimica,
  • Tatjana Ćosić,
  • Branka Uzelac,
  • Slavica Ninković and
  • Martin Raspor

21 March 2024

Numerous biotechnological applications require a fast and efficient clonal propagation of whole plants under controlled laboratory conditions. For most plant species, the de novo regeneration of shoots from the cuttings of various plant organs can be...

  • Article
  • Open Access
1 Citations
3,011 Views
16 Pages

Inhibition of Granule Cell Dispersion and Seizure Development by Astrocyte Elevated Gene-1 in a Mouse Model of Temporal Lobe Epilepsy

  • Eunju Leem,
  • Sehwan Kim,
  • Chanchal Sharma,
  • Youngpyo Nam,
  • Tae Yeon Kim,
  • Minsang Shin,
  • Seok-Geun Lee,
  • Jaekwang Kim and
  • Sang Ryong Kim

20 March 2024

Although granule cell dispersion (GCD) in the hippocampus is known to be an important feature associated with epileptic seizures in temporal lobe epilepsy (TLE), the endogenous molecules that regulate GCD are largely unknown. In the present study, we...

  • Article
  • Open Access
1 Citations
2,122 Views
18 Pages

Postweaning Development Influences Endogenous VPAC1 Modulation of LTP Induced by Theta-Burst Stimulation: A Link to Maturation of the Hippocampal GABAergic System

  • Marta Gil,
  • Ana Caulino-Rocha,
  • Marta Bento,
  • Nádia C. Rodrigues,
  • Armando Silva-Cruz,
  • Joaquim A. Ribeiro and
  • Diana Cunha-Reis

20 March 2024

Long-term potentiation (LTP) induced by theta-burst stimulation (TBS) undergoes postweaning developmental changes partially linked to GABAergic circuit maturation. Endogenous vasoactive intestinal peptide (VIP) acting on its VPAC1 receptor strongly i...

  • Review
  • Open Access
9 Citations
5,533 Views
24 Pages

20 March 2024

Ischemic stroke is a fatal and disabling disease worldwide and imposes a significant burden on society. At present, biological markers that can be conveniently measured in body fluids are lacking for the diagnosis of ischemic stroke, and there are no...

  • Article
  • Open Access
5 Citations
3,803 Views
13 Pages

20 March 2024

Amyotrophic lateral sclerosis (ALS) that comprises sporadic (sALS) and familial (fALS) cases, is a devastating neurodegenerative disorder characterized by progressive degeneration of motor neurons, leading to muscle atrophy and various clinical manif...

  • Article
  • Open Access
2 Citations
2,818 Views
14 Pages

Role of Polyunsaturated Fatty Acids (PUFAs) and Eicosanoids on Dry Eye Symptoms and Signs

  • Simran Mangwani-Mordani,
  • Amanda Prislovsky,
  • Daniel Stephenson,
  • Charles E. Chalfant,
  • Anat Galor and
  • Nawajes Mandal

20 March 2024

Polyunsaturated fatty acids (PUFAs) generate pro- and anti-inflammatory eicosanoids via three different metabolic pathways. This study profiled tear PUFAs and their metabolites and examined the relationships with dry eye (DE) and meibomian gland dysf...

  • Article
  • Open Access
2 Citations
3,083 Views
13 Pages

Crystallization of Ethylene Plant Hormone Receptor—Screening for Structure

  • Buket Rüffer,
  • Yvonne Thielmann,
  • Moritz Lemke,
  • Alexander Minges and
  • Georg Groth

20 March 2024

The plant hormone ethylene is a key regulator of plant growth, development, and stress adaptation. Many ethylene-related responses, such as abscission, seed germination, or ripening, are of great importance to global agriculture. Ethylene perception...

  • Article
  • Open Access
4 Citations
3,513 Views
14 Pages

Epitope Mapping of Japanese Encephalitis Virus Neutralizing Antibodies by Native Mass Spectrometry and Hydrogen/Deuterium Exchange

  • Jagat Adhikari,
  • James Heffernan,
  • Melissa Edeling,
  • Estefania Fernandez,
  • Prashant N. Jethva,
  • Michael S. Diamond,
  • Daved H. Fremont and
  • Michael L. Gross

20 March 2024

Japanese encephalitis virus (JEV) remains a global public health concern due to its epidemiological distribution and the existence of multiple strains. Neutralizing antibodies against this infection have shown efficacy in in vivo studies. Thus, eluci...

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Biomolecules - ISSN 2218-273X