Topic Editors

Dr. Davide Moi
Department of Life and Environmental Sciences, University of Cagliari, University Campus, S.P. 8 CA, 09042 Monserrato, Italy
Prof. Dr. Daniele Passarella
Department of Chemistry, University of Milan, Via Golgi 19, 20133 Milano, Italy
Department of Chemistry, University of Milan, Via Golgi 19, 20133 Milan, Italy

Design, Synthesis and Biological Evaluation of Novel Small Molecules as Multi-target Enzyme Inhibitors

Abstract submission deadline
30 September 2024
Manuscript submission deadline
31 January 2025
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Topic Information

Dear Colleagues,

We are delighted to announce the initiation of a Topic, "Design, Synthesis and Biological Evaluation of Novel Small Molecules as Multi-target Enzyme Inhibitors", dedicated to exploring the dynamic intersection of synthetic organic chemistry and biology, with profound implications for diverse medical applications.

Within this specialized topic, our focus is on the synthesis and biological assessment of novel small molecules designed to inhibit multiple enzymes concurrently. Multi-target enzyme inhibitors offer a comprehensive treatment approach by simultaneously targeting multiple disease-related pathways, enhancing therapeutic efficacy. Their ability to mitigate drug resistance, improve selectivity, and potentially provide synergistic effects makes them promising candidates for treating complex diseases. Additionally, the versatility of these inhibitors allows for a more personalized treatment strategy, addressing the multifactorial origins of various medical conditions.

The synthesis process involves optimizing for favorable pharmacokinetic properties and target specificity, leading to a varied library of compounds. The potential applications of the target inhibitors extend into critical areas of medical research, including neurological disorders, the antimicrobial field, antidiabetic therapies, and so on.

We also welcome investigations into novel synthetic methodologies, recognizing their importance in developing innovative strategies to access multi-target inhibitors. Contributions in the form of reviews and original research papers are encouraged for publication. We invite your participation in creating a comprehensive collection of articles, promoting a deeper understanding of the synthesis and evaluation of small molecules with multi-target enzyme-inhibitory properties and the development of novel synthetic routes.

We eagerly anticipate and welcome your valuable contributions to advancing the discourse surrounding this exciting and rapidly evolving field.

Dr. Davide Moi
Prof. Dr. Daniele Passarella
Dr. Andrea Citarella
Topic Editors


  • organic synthesis
  • medicinal chemistry
  • enzyme inhibitors
  • synthetic methodologies
  • bioactive compounds
  • drug design
  • molecular modelling
  • drug discovery

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
- - 2021 54 Days CHF 1000 Submit
5.5 8.3 2011 16.9 Days CHF 2700 Submit
Current Issues in Molecular Biology
3.1 2.4 1999 13.5 Days CHF 2200 Submit
4.6 6.7 1996 14.6 Days CHF 2700 Submit
5.4 6.9 2009 14.2 Days CHF 2900 Submit
Scientia Pharmaceutica
2.5 6.4 1930 22.7 Days CHF 1000 Submit is a multidiscipline platform providing preprint service that is dedicated to sharing your research from the start and empowering your research journey.

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Published Papers

This Topic is now open for submission.
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