Design, Synthesis and Biological Evaluation of Novel Small Molecules as Multi-target Enzyme Inhibitors
We are delighted to announce the initiation of a Topic, "Design, Synthesis and Biological Evaluation of Novel Small Molecules as Multi-target Enzyme Inhibitors", dedicated to exploring the dynamic intersection of synthetic organic chemistry and biology, with profound implications for diverse medical applications.
Within this specialized topic, our focus is on the synthesis and biological assessment of novel small molecules designed to inhibit multiple enzymes concurrently. Multi-target enzyme inhibitors offer a comprehensive treatment approach by simultaneously targeting multiple disease-related pathways, enhancing therapeutic efficacy. Their ability to mitigate drug resistance, improve selectivity, and potentially provide synergistic effects makes them promising candidates for treating complex diseases. Additionally, the versatility of these inhibitors allows for a more personalized treatment strategy, addressing the multifactorial origins of various medical conditions.
The synthesis process involves optimizing for favorable pharmacokinetic properties and target specificity, leading to a varied library of compounds. The potential applications of the target inhibitors extend into critical areas of medical research, including neurological disorders, the antimicrobial field, antidiabetic therapies, and so on.
We also welcome investigations into novel synthetic methodologies, recognizing their importance in developing innovative strategies to access multi-target inhibitors. Contributions in the form of reviews and original research papers are encouraged for publication. We invite your participation in creating a comprehensive collection of articles, promoting a deeper understanding of the synthesis and evaluation of small molecules with multi-target enzyme-inhibitory properties and the development of novel synthetic routes.
We eagerly anticipate and welcome your valuable contributions to advancing the discourse surrounding this exciting and rapidly evolving field.
Dr. Davide Moi
Prof. Dr. Daniele Passarella
Dr. Andrea Citarella
- organic synthesis
- medicinal chemistry
- enzyme inhibitors
- synthetic methodologies
- bioactive compounds
- drug design
- molecular modelling
- drug discovery
|First Decision (median)
Current Issues in Molecular Biology
Preprints.org is a multidiscipline platform providing preprint service that is dedicated to sharing your research from the start and empowering your research journey.
MDPI Topics is cooperating with Preprints.org and has built a direct connection between MDPI journals and Preprints.org. Authors are encouraged to enjoy the benefits by posting a preprint at Preprints.org prior to publication:
- Immediately share your ideas ahead of publication and establish your research priority;
- Protect your idea from being stolen with this time-stamped preprint article;
- Enhance the exposure and impact of your research;
- Receive feedback from your peers in advance;
- Have it indexed in Web of Science (Preprint Citation Index), Google Scholar, Crossref, SHARE, PrePubMed, Scilit and Europe PMC.