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Biomolecules, Volume 14, Issue 11

2024 November - 139 articles

Cover Story: Unmistakable accounts of cancer with clinical characteristics, as are understood today, begin in the fifth century B.C. with Hippocrates of Cos and later in the second century A.D. with Galen of Pergamum, addressing the incidence of cancer, predominantly in advanced age, the clinical characteristics of the disease, its life‑threatening course, and attempts to treat it. The principles and practices of the Hippocratic and Galenic traditions—especially the concept of early cancer detection to ensure cure—have virtually dominated cancer care well into the 20th century. Sequencing technologies at the dawn of the 21st century have opened a new era of therapeutic intervention, broadly, as well as at the level of personal genomes. Gene therapy for cancer treatment encompasses different approaches such as immunotherapy, oncolysis mediated by viruses, and gene transfer. View this paper
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Articles (139)

  • Review
  • Open Access
22 Citations
6,762 Views
50 Pages

Anti-Diabetic Therapies and Cancer: From Bench to Bedside

  • Dimitris Kounatidis,
  • Natalia G. Vallianou,
  • Irene Karampela,
  • Eleni Rebelos,
  • Marina Kouveletsou,
  • Vasileios Dalopoulos,
  • Petros Koufopoulos,
  • Evanthia Diakoumopoulou,
  • Nikolaos Tentolouris and
  • Maria Dalamaga

20 November 2024

Diabetes mellitus (DM) is a significant risk factor for various cancers, with the impact of anti-diabetic therapies on cancer progression differing across malignancies. Among these therapies, metformin has gained attention for its potential anti-canc...

  • Review
  • Open Access
6 Citations
5,210 Views
25 Pages

Research Progress of Fibroblasts in Human Diseases

  • Xiaodong Li,
  • Nana Li,
  • Yujie Wang,
  • Qixiang Han and
  • Boshi Sun

20 November 2024

Fibroblasts, which originate from embryonic mesenchymal cells, are the predominant cell type seen in loose connective tissue. As the main components of the internal environment that cells depend on for survival, fibroblasts play an essential role in...

  • Article
  • Open Access
3 Citations
2,025 Views
20 Pages

20 November 2024

Mitochondrial DNA (mtDNA) supplementation can rescue poor oocyte quality and overcome embryonic arrest. Here, we investigated a series of sexually mature pigs generated through autologous and heterologous mtDNA supplementation. Brain, liver and heart...

  • Article
  • Open Access
7 Citations
2,947 Views
15 Pages

20 November 2024

Accumulation of senescent endothelial cells (ECs) in vasculature represents a key step in the development of vascular aging and ensuing age-related diseases. Given that removal of senescent ECs may prevent disease and improve health and wellbeing, th...

  • Review
  • Open Access
9 Citations
5,094 Views
16 Pages

20 November 2024

Insulin-like growth factor-binding protein-1 (IGFBP-1) contributes to the regulation of IGFs for metabolism and growth and has IGF-independent actions. IGFBP-1 in the circulation is derived from the liver, where it is inhibited by insulin and stimula...

  • Article
  • Open Access
1 Citations
2,167 Views
18 Pages

19 November 2024

Alcohol dehydrogenases (ADHs) are critical enzymes involved in the oxidation of alcohols, contributing to various metabolic pathways across organisms. This study investigates type I functional divergence within three ADH1 families: Saccharomyces cere...

  • Article
  • Open Access
2 Citations
2,024 Views
9 Pages

Serum Leucine-Rich Alpha-2 Glycoprotein 1 Levels in Patients with Lipodystrophy Syndromes

  • Michelle Krienke,
  • Susan Kralisch,
  • Leonie Wagner,
  • Anke Tönjes and
  • Konstanze Miehle

19 November 2024

Serum concentrations of leucine-rich alpha-2 glycoprotein 1 (LRG1) are elevated in several cardio-metabolic and inflammatory diseases. LRG1 also plays an important role in the development of hepatic steatosis and insulin resistance. In lipodystrophie...

  • Article
  • Open Access
7 Citations
4,858 Views
17 Pages

The Antifungal Potential of Ozonated Extra-Virgin Olive Oil Against Candida albicans: Mechanisms and Efficacy

  • Simone Augello,
  • Valentina Cameli,
  • Arianna Montanari,
  • Stefano Tacconi,
  • Daniela Uccelletti,
  • Luciana Dini and
  • Emily Schifano

19 November 2024

The growing emergence of resistance mechanisms and side effects associated with antifungal agents highlight the need for alternative therapies. This study aims to investigate the antifungal potential of ozonated extra-virgin olive oil (EOO) against C...

  • Article
  • Open Access
2 Citations
1,924 Views
15 Pages

19 November 2024

Lipid membranes, which are fundamental to cellular function, undergo various mechanical deformations. Accurate modeling of these processes necessitates a thorough understanding of membrane elasticity. The lateral shear modulus, a critical parameter d...

  • Article
  • Open Access
3 Citations
8,601 Views
16 Pages

Effect of a Concurrent Training Program with and Without Metformin Treatment on Metabolic Markers and Cardiorespiratory Fitness in Individuals with Insulin Resistance: A Retrospective Analysis

  • Jairo Azócar-Gallardo,
  • Alex Ojeda-Aravena,
  • Eduardo Báez-San Martín,
  • Tomás Herrera-Valenzuela,
  • Marcelo Tuesta,
  • Luis González-Rojas,
  • Bibiana Calvo-Rico and
  • José Manuel García-García

19 November 2024

Background: Type 2 diabetes mellitus is a metabolic disorder characterized by insulin resistance (IR), which is prevalent worldwide and has significant adverse health effects. Metformin is commonly prescribed as a pharmacological treatment. Physical...

  • Article
  • Open Access
2,316 Views
15 Pages

Advances in the Regulation of Periostin for Osteoarthritic Cartilage Repair Applications

  • Sunny Y. Shih,
  • Michael P. Grant,
  • Laura M. Epure,
  • Muskan Alad,
  • Sophie Lerouge,
  • Olga L. Huk,
  • Stephane G. Bergeron,
  • David J. Zukor,
  • Géraldine Merle and
  • Fackson Mwale
  • + 2 authors

18 November 2024

Emerging evidence indicates periostin (POSTN) is upregulated in patients with OA, and studies have shown that it can induce the activation of inflammatory cytokines and catabolic enzymes, making it a potential therapeutic target. Link N (LN) is a pep...

  • Article
  • Open Access
8 Citations
3,543 Views
15 Pages

18 November 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a recently introduced term for steatotic liver disease (SLD). Although the inflammatory process is central to the pathogenesis of SLD, research investigating the differences in syste...

  • Article
  • Open Access
2 Citations
3,548 Views
15 Pages

18 November 2024

Type 2 diabetes (T2D) is often comorbid with cardiovascular diseases (CVDs). The direction of causation between T2D and CVD is difficult to determine; however, there may be a common underlying pathway attributable to shared genetic factors. We aimed...

  • Article
  • Open Access
12 Citations
2,445 Views
15 Pages

Methyl Paraben Affects Porcine Oocyte Maturation Through Mitochondrial Dysfunction

  • Huimei Huang,
  • Chuman Huang,
  • Yinghua Li,
  • Xingwei Liang,
  • Namhyung Kim and
  • Yongnan Xu

18 November 2024

Parabens are widely used in various industries, which are including chemical, pharmaceutical, food, cosmetic, and plastic processing industries. Among these, methyl paraben (MP) serves as an antimicrobial preservative in processed foods, pharmaceutic...

  • Review
  • Open Access
24 Citations
4,800 Views
16 Pages

Cardio-Lipotoxicity of Epicardial Adipose Tissue

  • Monica L. Bodenstab,
  • Ron T. Varghese and
  • Gianluca Iacobellis

18 November 2024

Epicardial adipose tissue is a unique visceral adipose tissue depot that plays a crucial role in myocardial metabolism. Epicardial adipose tissue is a major source of energy and free fatty acids for the adjacent myocardium. However, under pathologica...

  • Article
  • Open Access
6 Citations
2,848 Views
22 Pages

Schinus molle Resin Essential Oil as Potent Bioinsecticide Against Tribolium castaneum: Chemical Profile, In Vitro Acetylcholinesterase Inhibition, DFT Calculation and Molecular Docking Analysis

  • Wiem Baccari,
  • Ilyes Saidi,
  • Achref Jebnouni,
  • Safa Teka,
  • Sayda Osman,
  • Awatif Mansoor Alrasheeday,
  • Nuzaiha Mohamed,
  • Mabrouka El Oudi and
  • Hichem Ben Jannet

18 November 2024

Plants offer a bountiful source of natural pest control solutions through their essential oils. This research introduces and analyzes an eco-friendly natural essential oil for red flour beetle control. Therefore, the current study was included to sho...

  • Review
  • Open Access
11 Citations
7,076 Views
26 Pages

18 November 2024

Trimethylamine-N-oxide (TMAO) is a gut microbiota-derived metabolite, the production of which in vivo is mainly regulated by dietary choices, gut microbiota, and the hepatic enzyme flavin monooxygenase (FMO), while its elimination occurs via the kidn...

  • Review
  • Open Access
2 Citations
3,601 Views
30 Pages

Activins and Inhibins in Cardiovascular Pathophysiology

  • Wenyi Tang,
  • Zhilin Gu,
  • Jiuqi Guo,
  • Mingzhi Lin,
  • Hongqian Tao,
  • Dalin Jia and
  • Pengyu Jia

18 November 2024

Activins and inhibins, members of the transforming growth factor β (TGFβ) superfamily, were initially recognized for their opposing effects on the secretion of follicle-stimulating hormone. Subsequent research has demonstrated their broader...

  • Perspective
  • Open Access
2 Citations
3,214 Views
10 Pages

18 November 2024

Polyunsaturated fatty acids such as arachidonic acid are indispensable components of innate immune signaling. Plasmalogens are glycerophospholipids with a vinyl ether bond in the sn-1 position of the glycerol backbone instead of the more common sn-1...

  • Article
  • Open Access
4 Citations
3,724 Views
15 Pages

Tumor-Colonizing E. coli Expressing Both Collagenase and Hyaluronidase Enhances Therapeutic Efficacy of Gemcitabine in Pancreatic Cancer Models

  • Lara C. Avsharian,
  • Suvithanandhini Loganathan,
  • Nancy D. Ebelt,
  • Azadeh F. Shalamzari,
  • Itzel Rodarte Muñoz and
  • Edwin R. Manuel

17 November 2024

Desmoplasia is a hallmark feature of pancreatic ductal adenocarcinoma (PDAC) that contributes significantly to treatment resistance. Approaches to enhance drug delivery into fibrotic PDAC tumors continue to be an important unmet need. In this study,...

  • Perspective
  • Open Access
1 Citations
7,598 Views
14 Pages

17 November 2024

In the elderly, cerebral amyloid angiopathy (CAA) is the most common cause for intracranial lobar hemorrhages. CAA is caused by the accumulation of amyloid-β fibrils in cortical and leptomeningeal vessels. In 2022, the Boston Criteria 2.0 became...

  • Review
  • Open Access
11 Citations
4,029 Views
21 Pages

17 November 2024

Widespread endocrine disorders and infertility caused by environmental and food pollutants have drawn considerable global attention. Aflatoxins (AFTs), a prominent class of mycotoxins, are recognized as one of the key contributors to environmental an...

  • Article
  • Open Access
7 Citations
3,029 Views
16 Pages

Modulation of the Gut–Lung Axis by Water Kefir and Kefiran and Their Impact on Toll-like Receptor 3-Mediated Respiratory Immunity

  • Stefania Dentice Maidana,
  • Julio Nicolás Argañaraz Aybar,
  • Leonardo Albarracin,
  • Yoshiya Imamura,
  • Luciano Arellano-Arriagada,
  • Fu Namai,
  • Yoshihito Suda,
  • Keita Nishiyama,
  • Julio Villena and
  • Haruki Kitazawa

17 November 2024

The beneficial effect of milk kefir on respiratory heath has been previously demonstrated; however, water kefir and kefiran in the context of respiratory viral infections have not been investigated. Water kefir and kefiran could be alternatives to mi...

  • Article
  • Open Access
16 Citations
4,095 Views
18 Pages

Angiotensin II Induces Vascular Endothelial Dysfunction by Promoting Lipid Peroxidation-Mediated Ferroptosis via CD36

  • Qian Zhou,
  • Ying Zhang,
  • Wei Shi,
  • Lu Lu,
  • Jianglan Wei,
  • Jinhan Wang,
  • Hu Zhang,
  • Yuepu Pu and
  • Lihong Yin

17 November 2024

Angiotensin II (Ang II) is an effective vasoconstriction peptide, a major effector molecule of the renin–angiotensin–aldosterone system (RAAS) and one of the important causes of endothelial dysfunction. Ferroptosis is considered to be inv...

  • Article
  • Open Access
7 Citations
8,462 Views
23 Pages

Chaga Mushroom Triterpenoids Inhibit Dihydrofolate Reductase and Act Synergistically with Conventional Therapies in Breast Cancer

  • Junbiao Wang,
  • Daniela Beghelli,
  • Augusto Amici,
  • Stefania Sut,
  • Stefano Dall’Acqua,
  • Giulio Lupidi,
  • Diego Dal Ben,
  • Onelia Bistoni,
  • Daniele Tomassoni and
  • Cristina Marchini
  • + 4 authors

17 November 2024

Inonotus obliquus (Chaga) is a medicinal mushroom with several pharmacological properties that is used as a tea in traditional Chinese medicine. In this study, Chaga water extract was digested in vitro to mimic the natural processing and absorption o...

  • Article
  • Open Access
5 Citations
3,543 Views
15 Pages

Exosomes from Human Periodontal Ligament Stem Cells Promote Differentiation of Osteoblast-like Cells and Bone Healing in Rat Calvarial Bone

  • Mhd Safwan Albougha,
  • Hideki Sugii,
  • Orie Adachi,
  • Bara Mardini,
  • Serina Soeno,
  • Sayuri Hamano,
  • Daigaku Hasegawa,
  • Shinichiro Yoshida,
  • Tomohiro Itoyama and
  • Hidefumi Maeda
  • + 1 author

17 November 2024

Deep caries and severe periodontitis cause bone resorption in periodontal tissue, and severe bone resorption leads to tooth loss. Periodontal ligament stem cells (PDLSCs) are important for the healing of defective periodontal tissue. It is increasing...

  • Communication
  • Open Access
4 Citations
1,542 Views
9 Pages

Tissue-Specific Effects of Aging on Repeat-Mediated Mutation Hotspots In Vivo

  • Alexandra M. D’Amico,
  • Tonia T. Li and
  • Karen M. Vasquez

16 November 2024

Aging constitutes complex and dynamic alterations in molecular and physiological processes and is associated with numerous disorders, in part due to increased genetic instability. The aging population is projected to double by 2050, underscoring the...

  • Review
  • Open Access
15 Citations
4,503 Views
25 Pages

Targeting the mTOR-Autophagy Axis: Unveiling Therapeutic Potentials in Osteoporosis

  • Rongjin Chen,
  • Chenhui Yang,
  • Fei Yang,
  • Ao Yang,
  • Hefang Xiao,
  • Bo Peng,
  • Changshun Chen,
  • Bin Geng and
  • Yayi Xia

15 November 2024

Osteoporosis (OP) is a widespread age-related disorder marked by decreased bone density and increased fracture risk, presenting a significant public health challenge. Central to the development and progression of OP is the dysregulation of the mechan...

  • Article
  • Open Access
1 Citations
1,653 Views
15 Pages

Assessing the Impact of Bedaquiline, Clofazimine, and Linezolid on Mycobacterial Genome Integrity

  • Dániel Molnár,
  • Éva Viola Surányi,
  • Nikoletta Gálik,
  • Judit Tóth and
  • Rita Hirmondó

15 November 2024

Tuberculosis (TB) presents significant medical challenges, largely due to the genetic diversity of Mycobacterium tuberculosis, which enhances the resilience and resistance of the pathogen to first-line treatments. In response to the global rise of dr...

  • Article
  • Open Access
2 Citations
2,000 Views
16 Pages

Copy Number Variants in Cardiac Channelopathies: Still a Missed Part in Routine Arrhythmic Diagnostics

  • Maria Gnazzo,
  • Giovanni Parlapiano,
  • Francesca Di Lorenzo,
  • Daniele Perrino,
  • Silvia Genovese,
  • Valentina Lanari,
  • Daniela Righi,
  • Federica Calì,
  • Massimo Stefano Silvetti and
  • Anwar Baban
  • + 4 authors

15 November 2024

Inherited cardiac channelopathies are major causes of sudden cardiac death (SCD) in young people. Genetic testing is focused on the identification of single-nucleotide variants (SNVs) by Next-Generation Sequencing (NGS). However, genetically elusive...

  • Article
  • Open Access
8 Citations
3,647 Views
17 Pages

Tryptophan Metabolites in the Progression of Liver Diseases

  • Maria Reshetova,
  • Pavel Markin,
  • Svetlana Appolonova,
  • Ismail Yunusov,
  • Oksana Zolnikova,
  • Elena Bueverova,
  • Natiya Dzhakhaya,
  • Maria Zharkova,
  • Elena Poluektova and
  • Vladimir Ivashkin
  • + 1 author

15 November 2024

The aim of this study was to investigate the levels of various tryptophan metabolites in patients with alcoholic liver disease (ALD) and metabolic-associated fatty liver disease (MAFLD) at different stages of the disease. The present study included 4...

  • Review
  • Open Access
3 Citations
3,747 Views
25 Pages

14 November 2024

The efficient analysis and interpretation of biological sequence data remain major challenges in bioinformatics. Graphical representation, as an emerging and effective visualization technique, offers a more intuitive method for analyzing DNA sequence...

  • Article
  • Open Access
2 Citations
2,082 Views
13 Pages

deepBBQ: A Deep Learning Approach to the Protein Backbone Reconstruction

  • Justyna D. Kryś,
  • Maksymilian Głowacki ,
  • Piotr Śmieja  and
  • Dominik Gront

14 November 2024

Coarse-grained models have provided researchers with greatly improved computational efficiency in modeling structures and dynamics of biomacromolecules, but, to be practically useful, they need fast and accurate conversion methods back to the all-ato...

  • Review
  • Open Access
12 Citations
4,932 Views
28 Pages

Targeting PDGF/PDGFR Signaling Pathway by microRNA, lncRNA, and circRNA for Therapy of Vascular Diseases: A Narrow Review

  • Chao-Nan Ma,
  • Shan-Rui Shi,
  • Xue-Ying Zhang,
  • Guo-Song Xin,
  • Xiang Zou,
  • Wen-Lan Li and
  • Shou-Dong Guo

14 November 2024

Despite the significant progress in diagnostic and therapeutic strategies, vascular diseases, such as cardiovascular diseases (CVDs) and respiratory diseases, still cannot be successfully eliminated. Vascular cells play a key role in maintaining vasc...

  • Review
  • Open Access
18 Citations
8,929 Views
13 Pages

Exploring PPAR Gamma and PPAR Alpha’s Regulation Role in Metabolism via Epigenetics Mechanism

  • Małgorzata Małodobra-Mazur,
  • Monika Ołdakowska and
  • Tadeusz Dobosz

13 November 2024

Peroxisome proliferator-activated receptors (PPARs) belong to a family of nuclear receptors. To date, three types of PPARs, namely PPARα, PPARδ, and PPARγ, have been identified, demonstrating co-expression across numerous tissues. P...

  • Article
  • Open Access
3 Citations
2,198 Views
16 Pages

Modulators of Alpha-2 Macroglobulin Upregulation by High Glucose in Glomerular Mesangial Cells

  • Jackie Trink,
  • Renzhong Li,
  • Bo Gao,
  • Chao Lu and
  • Joan C. Krepinsky

13 November 2024

Up to 40% of patients with diabetes mellitus will develop diabetic kidney disease (DKD), characterized pathologically by the accumulation of extracellular matrix proteins, which leads to the loss of kidney function over time. Our previous studies sho...

  • Review
  • Open Access
14 Citations
6,145 Views
26 Pages

Ferroptosis in Cancer: Epigenetic Control and Therapeutic Opportunities

  • Roberta Veglia Tranchese,
  • Sabrina Battista,
  • Laura Cerchia and
  • Monica Fedele

13 November 2024

Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has emerged as a critical pathway in cancer biology. This review delves into the epigenetic mechanisms that modulate ferroptosis in cancer cells, focusing on ho...

  • Review
  • Open Access
4,460 Views
15 Pages

13 November 2024

Many DNA metabolic pathways, including DNA repair, require the transmission of signals across long stretches of DNA or between DNA molecules. Solutions to this signaling challenge involve various mechanisms: protein factors can travel between these s...

  • Article
  • Open Access
6 Citations
2,568 Views
16 Pages

Novel Inhibitory Actions of Neuroactive Steroid [3α,5α]-3-Hydroxypregnan-20-One on Toll-like Receptor 4-Dependent Neuroimmune Signaling

  • Alejandro G. Lopez,
  • Venkat R. Chirasani,
  • Irina Balan,
  • Todd K. O’Buckley,
  • Makayla R. Adelman and
  • A. Leslie Morrow

13 November 2024

The endogenous neurosteroid (3α,5α)-3-hydroxypregnan-20-one (3α,5α-THP) modulates inflammatory and neuroinflammatory signaling through toll-like receptors (TLRs) in human and mouse macrophages, human blood cells and alcohol-pr...

  • Article
  • Open Access
1,772 Views
14 Pages

Production of Value-Added Arabinofuranosyl Nucleotide Analogues from Nucleoside by an In Vitro Enzymatic Synthetic Biosystem

  • Yuxue Liu,
  • Xiaojing Zhang,
  • Erchu Yang,
  • Xiaobei Liu,
  • Weiwei Su,
  • Zhenyu Wang and
  • Hailei Wang

13 November 2024

Arabinofuranosyl nucleotide analogue (arabinoside) and the derived compounds, a family of nucleoside analogues, exhibit diverse, typically biological activities and are widely used as antibacterial, antiviral, anti-inflammatory, and antitumor drugs i...

  • Article
  • Open Access
3 Citations
2,552 Views
21 Pages

Targeting APC/C Ubiquitin E3-Ligase Activation with Pyrimidinethylcarbamate Apcin Analogues for the Treatment of Breast Cancer

  • Maria Kapanidou,
  • Natalie L. Curtis,
  • Sandra S. Diaz-Minguez,
  • Sandra Agudo-Alvarez,
  • Alfredo Rus Sanchez,
  • Ammar Mayah,
  • Rosette Agena,
  • Paul Brennan,
  • Paula Morales and
  • Victor M. Bolanos-Garcia
  • + 2 authors

12 November 2024

Activation of the ubiquitin ligase APC/C by the protein Cdc20 is an essential requirement for proper cell division in higher organisms, including humans. APC/C is the ultimate effector of the Spindle Assembly Checkpoint (SAC), the signalling system t...

  • Review
  • Open Access
5 Citations
17,100 Views
20 Pages

Fasting as an Adjuvant Therapy for Cancer: Mechanism of Action and Clinical Practice

  • Yichun Xie,
  • Huabin Ye,
  • Zhongjun Liu,
  • Zhiqing Liang,
  • Jinrong Zhu,
  • Rongxin Zhang and
  • Yan Li

12 November 2024

The fundamental biological characteristics of tumor cells are characterized by irregularities in signaling and metabolic pathways, which are evident through increased glucose uptake, altered mitochondrial function, and the ability to evade growth sig...

  • Review
  • Open Access
5 Citations
7,162 Views
15 Pages

12 November 2024

Organoids have emerged as transformative tools in biomedical research, renowned for their ability to replicate the complexity construct of human tissues. Skin aging is a multifaceted biological process, influenced by both intrinsic factors and extrin...

  • Review
  • Open Access
7 Citations
3,346 Views
19 Pages

11 November 2024

Sterol biosynthesis is a crucial metabolic pathway in plants and various plant pathogens. Their vital physiological role in multicellular organisms and their effects on growth and reproduction underline their importance as membrane compounds, hormone...

  • Article
  • Open Access
5 Citations
3,612 Views
18 Pages

11 November 2024

Evidence has accumulated that Cannabis-derived compounds have the potential to treat neuroinflammatory changes present in neurodevelopmental conditions such as autism spectrum disorder. However, research is needed on the specific brain health benefit...

  • Review
  • Open Access
5 Citations
3,578 Views
34 Pages

Unraveling the Immune Web: Advances in SMI Capsular Fibrosis from Molecular Insights to Preclinical Breakthroughs

  • Ines Schoberleitner,
  • Klaus Faserl,
  • Michaela Lackner,
  • Débora C. Coraça-Huber,
  • Angela Augustin,
  • Anja Imsirovic,
  • Stephan Sigl and
  • Dolores Wolfram

11 November 2024

Breast implant surgery has evolved significantly, yet challenges such as capsular contracture remain a persistent concern. This review presents an in-depth analysis of recent advancements in understanding the immune mechanisms and clinical implicatio...

  • Article
  • Open Access
1 Citations
1,641 Views
17 Pages

Preparation and Antibacterial Properties of Poly (l-Lactic Acid)-Oriented Microporous Materials

  • Yihong Li,
  • Yanjun Feng,
  • Qingyi Huang,
  • Cenyi Luo,
  • Wei Chen,
  • Zhengqiu Li,
  • Lei Liu and
  • Jiafeng Li

11 November 2024

In this manuscript, an efficient self-reinforcing technology—solid hot drawing (SHD) technology—was combined with green processing supercritical carbon dioxide (SC-CO2) foaming technology to promote poly (l-lactic acid) (PLLA) to form an...

  • Article
  • Open Access
2,143 Views
12 Pages

Differential Lipid Signatures of Lumbar and Cisternal Cerebrospinal Fluid

  • Trine L. Toft-Bertelsen,
  • Søren Norge Andreassen,
  • Nicolas H. Norager,
  • Anja Hviid Simonsen,
  • Steen Gregers Hasselbalch,
  • Marianne Juhler and
  • Nanna MacAulay

11 November 2024

Background: The molecular composition of cerebrospinal fluid (CSF) is often used as a key indicator of biochemical alterations within distinct brain and spinal cord fluid compartments. The CSF protein content in lumbar CSF samples is widely employed...

  • Article
  • Open Access
4 Citations
2,048 Views
11 Pages

11 November 2024

Estrogen is a steroid hormone that plays a key role in regulating many physiological processes, such as follicle activation and development and oocyte maturation in mammals. Ca2+ is crucial in oogenesis, oocyte maturation, ovulation, and fertilizatio...

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