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Biomolecules, Volume 14, Issue 10

October 2024 - 142 articles

Cover Story: This paper delves into the mechanistic role of glycosphingolipids (GSLs) in cardiovascular disease, emphasizing their influence on inflammation, energy metabolism, and key signaling pathways that are crucial for heart function. GSLs interact with membrane microdomains, modulate mitochondrial dynamics, and impact lipid homeostasis, driving processes that contribute to heart failure. Through human and animal model studies, this work uncovers how disruptions in GSL metabolism are linked to oxidative stress, cardiac remodeling, and hypertrophy. These findings position GSLs as promising biomarkers and therapeutic targets for advancing cardiovascular treatment strategies. View this paper
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Articles (142)

  • Review
  • Open Access
14 Citations
5,000 Views
26 Pages

tRNA and tsRNA: From Heterogeneity to Multifaceted Regulators

  • Yun Li,
  • Zongyu Yu,
  • Wenlin Jiang,
  • Xinyi Lyu,
  • Ailian Guo,
  • Xiaorui Sun,
  • Yiting Yang and
  • Yunfang Zhang

21 October 2024

As the most ancient RNA, transfer RNAs (tRNAs) play a more complex role than their constitutive function as amino acid transporters in the protein synthesis process. The transcription and maturation of tRNA in cells are subject to stringent regulatio...

  • Review
  • Open Access
12 Citations
6,152 Views
23 Pages

21 October 2024

Breast cancer, the most prevalent malignant tumor among women globally, remains a critical area of focus for researchers striving to refine therapeutic approaches. As an important component of traditional Chinese medicine, Astragalus membranaceu...

  • Article
  • Open Access
1 Citations
2,033 Views
16 Pages

21 October 2024

Mutations in the parkin gene product Parkin give rise to autosomal recessive juvenile parkinsonism. Parkin is an E3 ubiquitin ligase that is a critical participant in the process of mitophagy. Parkin has a complex structure that integrates several al...

  • Correction
  • Open Access
1 Citations
855 Views
1 Page

21 October 2024

The authors would like to modify the Conflicts of Interest section of the published paper [...]

  • Article
  • Open Access
3 Citations
2,161 Views
20 Pages

Chemical Profiling of Polar Lipids and the Polyphenolic Fraction of Commercial Italian Phaseolus Seeds by UHPLC-HRMS and Biological Evaluation

  • Vadym Samukha,
  • Francesca Fantasma,
  • Gilda D’Urso,
  • Ester Colarusso,
  • Anna Schettino,
  • Noemi Marigliano,
  • Maria Giovanna Chini,
  • Gabriella Saviano,
  • Vincenzo De Felice and
  • Maria Iorizzi
  • + 3 authors

20 October 2024

The common bean (Phaseolus vulgaris L.) is one of the oldest food crops in the world. In this study, the ultra-high-performance liquid chromatography high-resolution mass spectrometry (UHPLC-MS/MS) technique was used to characterize the polar lipid c...

  • Article
  • Open Access
3 Citations
3,713 Views
17 Pages

Increased Cardiometabolic Risk in Men with Hypoprolactinemia: A Pilot Study

  • Robert Krysiak,
  • Karolina Kowalcze,
  • Witold Szkróbka and
  • Bogusław Okopień

20 October 2024

Low prolactin levels in men predispose them to mood disturbances, sexual dysfunction, and diabetes. The purpose of the current study was to assess cardiometabolic risk in males with hypoprolactinemia. This prospective study included three age-matched...

  • Review
  • Open Access
10 Citations
5,456 Views
19 Pages

Potential Roles of IP3 Receptors and Calcium in Programmed Cell Death and Implications in Cardiovascular Diseases

  • Chanon Piamsiri,
  • Nadezhda Fefelova,
  • Sri Harika Pamarthi,
  • Judith K. Gwathmey,
  • Siriporn C. Chattipakorn,
  • Nipon Chattipakorn and
  • Lai-Hua Xie

20 October 2024

Inositol 1,4,5-trisphosphate receptors (IP3Rs) play a crucial role in maintaining intracellular/cytosolic calcium ion (Ca2+i) homeostasis. The release of Ca2+ from IP3Rs serves as a second messenger and a modulatory factor influencing various intrace...

  • Review
  • Open Access
4 Citations
4,479 Views
15 Pages

Stress-Induced Evolution of the Nucleolus: The Role of Ribosomal Intergenic Spacer (rIGS) Transcripts

  • Anastasia A. Gavrilova,
  • Margarita V. Neklesova,
  • Yuliya A. Zagryadskaya,
  • Irina M. Kuznetsova,
  • Konstantin K. Turoverov and
  • Alexander V. Fonin

20 October 2024

It became clear more than 20 years ago that the nucleolus not only performs the most important biological function of assembling ribonucleic particles but is also a key controller of many cellular processes, participating in cellular adaptation to st...

  • Article
  • Open Access
4 Citations
3,163 Views
22 Pages

Identification of Multifunctional Putative Bioactive Peptides in the Insect Model Red Palm Weevil (Rhynchophorus ferrugineus)

  • Carmen Scieuzo,
  • Roberta Rinaldi,
  • Fabiana Giglio,
  • Rosanna Salvia,
  • Mohammed Ali AlSaleh,
  • Jernej Jakše,
  • Arnab Pain,
  • Binu Antony and
  • Patrizia Falabella

19 October 2024

Innate immunity, the body’s initial defense against bacteria, fungi, and viruses, heavily depends on antimicrobial peptides (AMPs), which are small molecules produced by all living organisms. Insects, with their vast biodiversity, are one of th...

  • Article
  • Open Access
3 Citations
2,535 Views
17 Pages

A Novel Peptide from VP1 of EV-D68 Exhibits Broad-Spectrum Antiviral Activity Against Human Enteroviruses

  • Xiaojing Lin,
  • Qiang Sun,
  • Yang Cao,
  • Zi Li,
  • Cuiling Xu,
  • Jun Liu,
  • Jingdong Song,
  • Kun Qin,
  • Yong Zhang and
  • Jianfang Zhou

19 October 2024

Enteroviruses have been a historical concern since the identification of polioviruses in humans. Wild polioviruses have almost been eliminated, while multiple species of non-polio enteroviruses and their variants co-circulate annually. To date, at le...

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Biomolecules - ISSN 2218-273X