The Molecular and Pathophysiological Basis of Ectopic Fat Deposition in Non-Adipose Tissues
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 31 May 2025 | Viewed by 4184
Special Issue Editors
Interests: metabolic basis of dyslipidemia; efficacy and safety of hypolipidemic drugs and nutrients; metabolic concomitants of obesity phenotypes
Special Issues, Collections and Topics in MDPI journals
Interests: insulin resistance; hepatology; diabetes; hypertension; metabolic syndrome; glucose metabolism; fatty liver; metabolism; nutrition
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
We are inviting reviews and/or original research papers for the Special Issue “The Molecular and Pathophysiological Basis of Ectopic Fat Deposition in Non-adipose tissues” for the journal
Ectopic fat deposition is a growing concern in metabolic diseases that increases the risk of morbidity and mortality. There are several types of cells affected by the intracellular accumulation of triglycerides in tissues including the liver, skeletal muscles, the heart, the pancreas, the kidneys and macrophages. The intracellular nidation and accumulation of neutral lipids interfere with the normal functions of the affected tissues. Some of the molecules involved in this process have been identified, but more studies need to be conducted on the pathways affected by the excessive accumulation of triglycerides. In addition, it is important to differentiate between the relative contribution of fasting versus feeding to lipid droplet formation and the impact of diet composition and/or physical activity to the overall accumulation of intracellular triglycerides.
This Special Issue focuses on the current state-of-the-art molecules that have been identified in the ectopic fat accumulation in tissues, with the histological and metabolic transformations that render affected tissues dysfunctional. Molecules that are potential pharmacotherapy targets are also of interest.
The manuscripts should emphasize the molecular basis of steatosis. Deadline for submission is November 2024.
Prof. Dr. Gloria Lena Vega
Prof. Dr. Amalia Gastaldelli
Guest Editors
Manuscript Submission Information
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Keywords
- metabolic dysfunction-associated hepatosteatosis
- myosteatosis
- pancreatic steatosis
- pancreatic adipocytes
- visceral adipose tissue
- cardiac steatosis
- cardiac adipose tissue
- kidney steatosis
- macrophage steatosis
- perirenal adipose tissue
- lipophagy
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