You are currently viewing a new version of our website. To view the old version click .
MDPIMDPI
Search all articles
Biomolecules
Submit to Biomolecules

Biomolecules, Volume 13, Issue 1

January 2023 - 187 articles

Cover Story: This article describes research associated with human exposure to cadmium, with an emphasis on its biological targets, toxic effects, and therapeutic approaches to counteract its chronic exposure. Higher amounts of Cd in the environment result from human activities as it spreads into the air and water. The human body has a limited ability to respond to Cd exposure. The toxicity of Cd2+ is, in part, due to its ability to mimic Zn2+ and Ca2+ in their biological roles. The mechanisms of Cd-induced carcinogenesis have been related to oxidative stress with the inhibition of antioxidant enzymes, the promotion of lipid peroxidation, and interference with DNA repair systems. In this work, a total of 12 cancer types associated with specific genes coding for the Cd-metalloproteome were identified. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (187)

  • Article
  • Open Access
7 Citations
2,960 Views
19 Pages
Download PDF

Intact Transition Epitope Mapping—Force Differences between Original and Unusual Residues (ITEM-FOUR)

  • Claudia Röwer,
  • Christian Ortmann,
  • Andrei Neamtu,
  • Reham F. El-Kased and
  • Michael O. Glocker
Biomolecules2023, 13(1), 187;https://doi.org/10.3390/biom13010187

16 January 2023

Antibody-based point-of-care diagnostics have become indispensable for modern medicine. In-depth analysis of antibody recognition mechanisms is the key to tailoring the accuracy and precision of test results, which themselves are crucial for targeted...

Full Article
  • Article
  • Open Access
2 Citations
2,891 Views
17 Pages
Download PDF

Developmental Inhibitory Changes in the Primary Somatosensory Cortex of the Stargazer Mouse Model of Absence Epilepsy

  • Muhammad Hassan,
  • David R. Grattan and
  • Beulah Leitch
Biomolecules2023, 13(1), 186;https://doi.org/10.3390/biom13010186

16 January 2023

Childhood absence epilepsy seizures arise in the cortico-thalamocortical network due to multiple cellular and molecular mechanisms, which are still under investigation. Understanding the precise mechanisms is imperative given that treatment fails in...

Full Article
  • Review
  • Open Access
63 Citations
9,326 Views
50 Pages
Download PDF

Recent Progress of Electrospun Herbal Medicine Nanofibers

  • Hang Liu,
  • Yubin Bai,
  • Chang Huang,
  • Ying Wang,
  • Yuexin Ji,
  • Yutong Du,
  • Lin Xu,
  • Deng-Guang Yu and
  • Sim Wan Annie Bligh
Biomolecules2023, 13(1), 184;https://doi.org/10.3390/biom13010184

16 January 2023

Herbal medicine has a long history of medical efficacy with low toxicity, side effects and good biocompatibility. However, the bioavailability of the extract of raw herbs and bioactive compounds is poor because of their low water solubility. In order...

Full Article
  • Feature Paper
  • Article
  • Open Access
9 Citations
5,692 Views
21 Pages
Download PDF

Single-Cell Profiling Comparisons of Tumor Microenvironment between Primary Advanced Lung Adenocarcinomas and Brain Metastases and Machine Learning Algorithms in Predicting Immunotherapeutic Responses

  • Yijun Wu,
  • Kai Kang,
  • Chang Han,
  • Li Wang,
  • Zhile Wang and
  • Ailin Zhao
Biomolecules2023, 13(1), 185;https://doi.org/10.3390/biom13010185

16 January 2023

Brain metastasis (BM) occurs commonly in patients with lung adenocarcinomas. Limited evidence indicates safety and efficacy of immunotherapy for this metastatic tumor, though immune checkpoint blockade has become the front-line treatment for primary...

Full Article
  • Feature Paper
  • Review
  • Open Access
30 Citations
7,390 Views
22 Pages
Download PDF

Type 2 Diabetes and Alzheimer’s Disease: The Emerging Role of Cellular Lipotoxicity

  • Nicola Marrano,
  • Giuseppina Biondi,
  • Anna Borrelli,
  • Martina Rella,
  • Tommaso Zambetta,
  • Ludovico Di Gioia,
  • Mariangela Caporusso,
  • Giancarlo Logroscino,
  • Sebastio Perrini and
  • Francesco Giorgino
  • + 1 author
Biomolecules2023, 13(1), 183;https://doi.org/10.3390/biom13010183

16 January 2023

Type 2 diabetes (T2D) and Alzheimer’s diseases (AD) represent major health issues that have reached alarming levels in the last decades. Although growing evidence demonstrates that AD is a significant comorbidity of T2D, and there is a ~1.4&nda...

Full Article
  • Article
  • Open Access
9 Citations
5,380 Views
14 Pages
Download PDF

Ragweed Major Allergen Amb a 11 Recombinant Production and Clinical Implications

  • Tudor-Paul Tamaș,
  • Maria-Roxana Buzan,
  • Lauriana-Eunice Zbîrcea,
  • Monica-Daniela Cotarcă,
  • Manuela Grijincu,
  • Virgil Păunescu,
  • Carmen Panaitescu and
  • Kuan-Wei Chen
Biomolecules2023, 13(1), 182;https://doi.org/10.3390/biom13010182

16 January 2023

Ragweed pollen is highly allergenic and elicits type I hypersensitivity reactions in the exposed populations. Amb a 11 is a recently discovered component of this pollen, and its biological role in allergy is still being researched. In our study, ragw...

Full Article
  • Feature Paper
  • Article
  • Open Access
5 Citations
3,959 Views
20 Pages
Download PDF

Age-Related Changes of the Synucleins Profile in the Mouse Retina

  • Sarah Batista Dias,
  • Luísa de Lemos,
  • Luís Sousa,
  • Diogo B. Bitoque,
  • Gabriela Araújo Silva,
  • Miguel C. Seabra and
  • Sandra Tenreiro
Biomolecules2023, 13(1), 180;https://doi.org/10.3390/biom13010180

15 January 2023

Alpha-synuclein (aSyn) plays a central role in Parkinson’s disease (PD) and has been extensively studied in the brain. This protein is part of the synuclein family, which is also composed of beta-synuclein (bSyn) and gamma-synuclein (gSyn). In...

Full Article
  • Feature Paper
  • Review
  • Open Access
11 Citations
4,771 Views
15 Pages
Download PDF

Is Glial Dysfunction the Key Pathogenesis of LRRK2-Linked Parkinson’s Disease?

  • Tatou Iseki,
  • Yuzuru Imai and
  • Nobutaka Hattori
Biomolecules2023, 13(1), 178;https://doi.org/10.3390/biom13010178

15 January 2023

Leucine rich-repeat kinase 2 (LRRK2) is the most well-known etiologic gene for familial Parkinson’s disease (PD). Its gene product is a large kinase with multiple functional domains that phosphorylates a subset of Rab small GTPases. However, st...

Full Article
  • Article
  • Open Access
4 Citations
2,745 Views
14 Pages
Download PDF

Multifunctional Modified Tumor Cell Membranes-Coated Adjuvant PTX against Melanoma

  • Zhonghua Ji,
  • Bingying Lin,
  • Enshuang Guan,
  • Mingsen Zhou,
  • Hui Wang and
  • Ying Hu
Biomolecules2023, 13(1), 179;https://doi.org/10.3390/biom13010179

14 January 2023

Melanoma is the deadliest type of skin cancer. Anti-tumor immunotherapy has made great progress in increasing the overall survival of patients. However, many physiological barriers cause low bioavailability of drugs. Cell membranes are becoming incre...

Full Article

of 19

Go to next page

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Biomolecules - ISSN 2218-273X
Imprint
Download Flyer