p53 Function and Dysfunction in Human Health and Diseases

Dear Colleagues,

This Topical Collection pertains to p53, one of the most intensively studied tumor suppressor proteins. Since its discovery, many cellular functions have been ascribed to p53, such as transcription regulation, signaling for apoptosis, involvement in the response to stress (such as genotoxic stress, the activation of oncogenes, and constitutive stress induced by factors such as hypoxia or starvation stress), senescence, DNA repair, metabolism, and immunity. The perturbation of p53 signaling pathways is required for the development of most cancers; however, it is now becoming clear that p53 can have a much broader role in human health and diseases. Thus, the activation of p53 might contribute to diseases such as neurodegenerative syndromes and also to the aging process. Much knowledge still needs to be acquired concerning the multiple contributions of this intriguing protein, not only in cancer development and the response to therapies, but also in other human diseases involving, for instance, immune dysfunction or redox state regulation. Here, we welcome papers describing recent advances in understanding p53 function and dysfunction in human diseases.

Dr. Gabriella D’Orazi
Collection Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.