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Biomolecules, Volume 11, Issue 3

March 2021 - 146 articles

 

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Cover Story: Circadian rhythm and the molecules involved in it, such as melanopsin and melatonin, play a key role in the eye to regulate homeostasis and even to treat some ocular conditions. As a result, many ocular pathologies, such as dry eye, corneal wound healing, cataracts, myopia, retinal diseases and glaucoma, are affected by this cycle. This review summarizes the current scientific literature about the influence of circadian patterns on the eye, focusing on its relationship with increased intraocular pressure and glaucoma. Further study is required on whether these treatments could improve their effect when posology is established in function of circadian patterns, as well as on if new drugs such as melatonin or its analogs, which are related to the circadian rhythm, not only could be used as the main treatment but as coadjutant, improving the circadian pattern or its antioxidant and antiangiogenic effect. View this paper

Articles (146)

  • Article
  • Open Access
14 Citations
4,603 Views
37 Pages

23 March 2021

Small cell lung cancer (SCLC) is a particularly aggressive tumor subtype, and dihydroorotate dehydrogenase (DHODH) has been demonstrated to be a therapeutic target for SCLC. Network pharmacology analysis and virtual screening were utilized to find ou...

  • Article
  • Open Access
10 Citations
4,859 Views
16 Pages

Selective Fatty Acid Retention and Turnover in the Freshwater Amphipod Pallaseopsis quadrispinosa

  • Sami J. Taipale,
  • Erwin Kers,
  • Elina Peltomaa,
  • John Loehr and
  • Martin J. Kainz

23 March 2021

Gammarid amphipods are a crucial link connecting primary producers with secondary consumers, but little is known about their nutritional ecology. Here we asked how starvation and subsequent feeding on different nutritional quality algae influences fa...

  • Article
  • Open Access
32 Citations
4,948 Views
22 Pages

23 March 2021

Phosphodiesterase 4 (PDE4), mainly present in immune, epithelial, and brain cells, represents a family of key enzymes for the degradation of cyclic adenosine monophosphate (cAMP), which modulates inflammatory response. In recent years, the inhibition...

  • Article
  • Open Access
9 Citations
4,261 Views
20 Pages

Zebrafish mafbb Mutants Display Osteoclast Over-Activation and Bone Deformity Resembling Osteolysis in MCTO Patients

  • Yujie Han,
  • Weihao Shao,
  • Dan Zhong,
  • Cui Ma,
  • Xiaona Wei,
  • Abrar Ahmed,
  • Tingting Yu,
  • Wei Jing and
  • Lili Jing

23 March 2021

Multicentric carpotarsal osteolysis (MCTO) is a rare skeletal dysplasia with osteolysis at the carpal and tarsal bones. Heterozygous missense mutations in the transcription factor MAFB are found in patients with MCTO. MAFB is reported to negatively r...

  • Article
  • Open Access
29 Citations
3,745 Views
19 Pages

MRAP2 Interaction with Melanocortin-4 Receptor in SnakeHead (Channa argus)

  • Zheng-Yong Wen,
  • Ting Liu,
  • Chuan-Jie Qin,
  • Yuan-Chao Zou,
  • Jun Wang,
  • Rui Li and
  • Ya-Xiong Tao

23 March 2021

The melanocortin-4 receptor (MC4R) plays an important role in the regulation of food intake and energy expenditure. Melanocortin-2 receptor accessory protein 2 (MRAP2) modulates trafficking, ligand binding, and signaling of MC4R. The Northern snakehe...

  • Article
  • Open Access
3 Citations
3,898 Views
19 Pages

23 March 2021

Neddylation is a post-translational modification that is essential for a variety of cellular processes and is linked to many human diseases including cancer, neurodegeneration, and autoimmune disorders. Neddylation involves the conjugation of the ubi...

  • Review
  • Open Access
43 Citations
7,464 Views
30 Pages

Multifaceted Functions of Protein Kinase D in Pathological Processes and Human Diseases

  • Xuejing Zhang,
  • Jaclyn Connelly,
  • Yapeng Chao and
  • Qiming Jane Wang

23 March 2021

Protein kinase D (PKD) is a family of serine/threonine protein kinases operating in the signaling network of the second messenger diacylglycerol. The three family members, PKD1, PKD2, and PKD3, are activated by a variety of extracellular stimuli and...

  • Article
  • Open Access
2 Citations
4,098 Views
15 Pages

Neisseria gonorrhoeae Multivalent Maxibody with a Broad Spectrum of Strain Specificity and Sensitivity for Gonorrhea Diagnosis

  • Jieun Jeong,
  • Jae-Seok Kim,
  • Junghyeon Lee,
  • Yu Ri Seo,
  • Eugene C. Yi and
  • Kristine M. Kim

23 March 2021

Gonorrhea is one of the most common, but still hidden and insidious, sexually transmitted diseases caused by Neisseria gonorrhoeae (gonococci). However, the diagnosis and treatment of gonorrhea are hampered by antigenic variability among gonococci, t...

  • Article
  • Open Access
16 Citations
5,690 Views
17 Pages

Chemoinformatic Screening for the Selection of Potential Senolytic Compounds from Natural Products

  • Oscar Salvador Barrera-Vázquez,
  • Juan Carlos Gómez-Verjan and
  • Gil Alfonso Magos-Guerrero

22 March 2021

Cellular senescence is a cellular condition that involves significant changes in gene expression and the arrest of cell proliferation. Recently, it has been suggested in experimental models that the elimination of senescent cells with pharmacological...

  • Review
  • Open Access
26 Citations
8,977 Views
28 Pages

The Cys Sense: Thiol Redox Switches Mediate Life Cycles of Cellular Proteins

  • Meytal Radzinski,
  • Tal Oppenheim,
  • Norman Metanis and
  • Dana Reichmann

22 March 2021

Protein homeostasis is an essential component of proper cellular function; however, sustaining protein health is a challenging task, especially during the aerobic lifestyle. Natural cellular oxidants may be involved in cell signaling and antibacteria...

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