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Diseases, Volume 13, Issue 11

2025 November - 31 articles

Cover Story: Heart failure with reduced ejection fraction (HFrEF) remains a condition with substantial mortality, even in stable outpatients receiving guideline-directed therapy. The blood urea/creatinine ratio (UCR) reflects both renal function and neurohormonal activation, yet its prognostic value in ambulatory settings has been unclear. In this study, we evaluated UCR at discharge from an outpatient heart failure service and found that UCR ≥95 was independently associated with increased all-cause mortality, even among patients with preserved renal function. These findings highlight UCR as a simple, accessible biomarker for identifying higher-risk patients in routine clinical practice. View this paper
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Articles (31)

  • Review
  • Open Access
3 Citations
8,686 Views
20 Pages

Zinc Fortification and Supplementation to Reduce Diarrhea in Children: A Literature Review

  • Sehar Iqbal,
  • Zoha Imtiaz Malik,
  • Maher Al Dabbas,
  • Ishmal Akhtar and
  • Aya Hussein

20 November 2025

Background: Zinc deficiency is a major global health issue and appears to be responsible for risk of diarrhea and death, particularly in children under 5 years. This review therefore aimed to summarize the existing literature related to zinc suppleme...

  • Case Report
  • Open Access
1,691 Views
7 Pages

Undetectable Serum Level of Anti-Müllerian Hormone (AMH) in a Woman with an Unpredictable Hyper-Response During Controlled Ovarian Stimulation for an IVF-ICSI Program: Case Report

  • Omar Sefrioui,
  • Modou Mamoune Mbaye,
  • Ismail Kaarouch,
  • Smahane Aboulmaouahib,
  • Latifa Ahbbas,
  • Omar Touzani,
  • Noureddine Louanjli and
  • Bouchra Ghazi

19 November 2025

Background/Objectives: A decrease in serum AMH is generally associated with low ovarian response in assisted reproductive procedures, whether or not in vitro fertilization (IVF) with intracytoplasmic sperm injection (ICSI) is performed. Methods: We r...

  • Article
  • Open Access
1 Citations
1,526 Views
15 Pages

Exploring Mitochondrial DNA Copy Number in Italian Children with ADHD: Implications for Neurobiological Mechanisms

  • Luigi Citrigno,
  • Annamaria Cerantonio,
  • Ludovico Neri,
  • Pierluigi Sebastiani,
  • Alessia Colanardi,
  • Gabriele Turacchio,
  • Tiziana Del Beato,
  • Beatrice Marziani and
  • Anna Aureli

19 November 2025

Background: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental condition frequently accompanied by behavioral dysregulation. While genetic factors involving monoaminergic systems have been implicated, emerging evidence suggests a...

(This article belongs to the Section Neuro-psychiatric Disorders)
  • Review
  • Open Access
5 Citations
3,194 Views
19 Pages

Reframing Dental Anxiety: Cognitive Behavioral Therapy and Its Role in Phobia Treatment—A Narrative Review

  • Dorina Stan,
  • Dragoș Voicu,
  • Pușica Zainea,
  • Alexandra Toma and
  • Anamaria Ciubară

18 November 2025

Dental phobia is a disabling yet underdiagnosed condition that prevents many patients from seeking essential oral healthcare, leading to avoidable pain, disease progression, and reduced quality of life. Cognitive Behavioral Therapy (CBT) is the most...

(This article belongs to the Special Issue Mental Health—Management and Care, Multidisciplinary Approaches and Perspectives)
  • Case Report
  • Open Access
1 Citations
2,825 Views
10 Pages

16 November 2025

Background: Toxic shock syndrome (TSS) is a rare but potentially fatal condition most often caused by Staphylococcus aureus or Streptococcus pyogenes. However, other streptococcal species, including Streptococcus agalactiae (group B Streptococcus (GB...

  • Article
  • Open Access
1 Citations
780 Views
16 Pages

Causal Graphical Model of Bacterial Vaginosis in Pregnant Women

  • Maricela García-Avalos,
  • Juana Canul-Reich,
  • Lil María Xibai Rodríguez-Henríquez and
  • Erick Natividad De la Cruz-Hernández

15 November 2025

Background: This study developed a Causal Graphical Model (CGM) to analyze Bacterial Vaginosis (BV), a condition caused by an imbalance in the vaginal microbiota, whose bacterial composition varies among women. While previous studies used variable se...

  • Article
  • Open Access
1,132 Views
13 Pages

T Helper and Cytotoxic T Cells Play an Important Role in Acute Gastric Injury

  • Irfan F. Corovic,
  • Jelena M. Pantic,
  • Isidora A. Stanisavljevic,
  • Sladjana M. Pavlovic,
  • Nemanja U. Jovicic,
  • Ivan P. Jovanovic,
  • Gordana D. Radosavljevic and
  • Bojana J. Simovic Markovic

15 November 2025

Background: Inflammation plays a central role in the formation of peptic ulcers, yet the contribution of cellular immunity remains poorly defined. This study aimed to clarify the contribution of cellular immunity to acute gastric mucosal injury. Meth...

(This article belongs to the Special Issue Diseases: From Molecular to the Clinical Perspectives)
  • Article
  • Open Access
4 Citations
3,067 Views
27 Pages

Stress, Anxiety, and Self-Efficacy in Hypertension: Evidence from a Romanian Case—Control Study

  • Lucia Bubulac,
  • Mirela Zivari,
  • Irina Anca Eremia,
  • Constantin Erena,
  • Consuela-Mădălina Gheorghe,
  • Iuliana-Raluca Gheorghe,
  • Viorica Tudor,
  • Claudia Florina Bogdan-Andreescu,
  • Emin Cadar and
  • Cristina-Crenguța Albu

13 November 2025

Background: Hypertension and psychological distress often coexist, though evidence from Eastern Europe is still limited. Stress, anxiety, and self-efficacy influence blood pressure control and treatment adherence. Their effect on hypertension prevent...

(This article belongs to the Special Issue Insights into the Management of Cardiovascular Disease Risk Factors)
  • Article
  • Open Access
3 Citations
1,897 Views
14 Pages

Silicosis and Pulmonary Functions Among Residents Exposed to Dust in Saraburi Thailand

  • Narongkorn Saiphoklang,
  • Pitchayapa Ruchiwit,
  • Apichart Kanitsap,
  • Pichaya Tantiyavarong,
  • Pasitpon Vatcharavongvan,
  • Srimuang Palungrit,
  • Kanyada Leelasittikul,
  • Apiwat Pugongchai and
  • Orapan Poachanukoon

13 November 2025

Background: Silicosis is a lung disease caused by inhalation of crystalline silica dust, leading to lung fibrosis, respiratory symptoms, and impaired lung function. This study aimed to determine the prevalence of silicosis, asthma, and chronic obstru...

  • Case Report
  • Open Access
20,316 Views
51 Pages

12 November 2025

Background: Neurological disorders are the leading cause of disability, affecting over three billion people worldwide. Amyotrophic lateral sclerosis (ALS) is among the most feared and uniformly fatal neurodegenerative diseases, with no therapy capabl...

(This article belongs to the Special Issue Research Progress in Neurodegenerative Diseases)
  • Article
  • Open Access
1 Citations
2,002 Views
9 Pages

12 November 2025

Background: Central precocious puberty (CPP) is diagnosed through a combination of clinical, auxological, and biochemical parameters, with pharmacological stimulation tests considered the diagnostic gold standard. In recent years, triptorelin, a long...

  • Case Report
  • Open Access
1,834 Views
12 Pages

11 November 2025

A traumatic elbow dislocation that remains unreduced for more than three weeks is considered a neglected elbow dislocation. We report a case of a patient with a neglected elbow dislocation combined with a terrible triad injury (elbow dislocation with...

  • Article
  • Open Access
2 Citations
1,945 Views
16 Pages

Risk Factors and Predictive Parameters of Necrotizing Enterocolitis in Preterm Infants—A Single-Center Retrospective Study

  • Tamas Toth,
  • Angela Borda,
  • Reka Borka-Balas,
  • Manuela Cucerea,
  • Emoke Andrea Szasz,
  • Horea Gozar and
  • Radu-Alexandru Prisca

10 November 2025

Background and Objectives: Necrotizing enterocolitis (NEC) represents a severe gastrointestinal emergency in preterm infants. The aim of this study was to identify risk factors and predictive parameters for NEC requiring surgery and to evaluate assoc...

  • Article
  • Open Access
1 Citations
2,101 Views
17 Pages

Psychological and Psychosocial Effects of Cancer on Young Patients and Survivors in Italy: A Mixed-Methods Study on the Challenges and Meaning-Making Factors

  • Martina Gentile,
  • Lucia Ronconi,
  • Marco Romeo,
  • Ciro De Vincenzo,
  • Elena Burattini,
  • Chiara Rutigliano,
  • Nicola Santoro,
  • Giulia Zucchetti,
  • Franca Fagioli and
  • Ines Testoni

10 November 2025

Background: Pediatric oncological diagnoses and treatments pose complex biopsychosocial challenges for both patients and their families. These experiences can significantly disrupt daily life, evoke intense emotional responses, and raise concerns abo...

(This article belongs to the Special Issue Mental Health—Management and Care, Multidisciplinary Approaches and Perspectives)
  • Article
  • Open Access
1,216 Views
10 Pages

In Vitro Activity of Silver-Bound Titanium Dioxide (TiAB) Against Multidrug-Resistant Vaginal Pathogens

  • Lorenzo Drago,
  • Luigi Regenburgh De La Motte,
  • Erika Stefàno,
  • Vincenzo Minasi,
  • Loredana Deflorio,
  • Sofia Benedetti and
  • Fabiana Giarritiello

10 November 2025

Background: Gynecological infections, including bacterial vaginosis, vulvovaginal candidiasis, and recurrent urinary tract infections, represent a major clinical burden and are often complicated by biofilm formation and antimicrobial resistance. Nove...

  • Article
  • Open Access
3 Citations
1,017 Views
17 Pages

Residual Platelet Reactivity and Dyslipidemia in Post-CABG Patients Undergoing Repeat Revascularization: Insights from Kazakhstan

  • Aisulu Mussagaliyeva,
  • Sholpan Zhangelova,
  • Laura Danyarova,
  • Friba Nurmukhammad,
  • Dina Kapsultanova,
  • Orazbek Sakhov,
  • Farida Rustamova,
  • Akhmetzhan Sugraliyev and
  • Dana Akhmentayeva

9 November 2025

Background: Coronary artery bypass grafting (CABG) remains a standard revascularization strategy for patients with advanced coronary artery disease (CAD). However, a considerable proportion of patients experience recurrent ischemia requiring repeat r...

(This article belongs to the Section Cardiology)
  • Article
  • Open Access
2 Citations
2,267 Views
21 Pages

Clinical Profiles, Management, and Outcomes of Complicated Pneumonia in Children: A Retrospective Study from Tertiary Centers in Jordan

  • Lina Alshadfan,
  • Muna Kilani,
  • Saleh Abualhaj,
  • Osama Abu-Salah,
  • Mohammad Ghassab Deameh,
  • Ahmad Nidal Al-Faouri,
  • Mustafa Elayyan,
  • Randa Othman and
  • Reem Abuzraiq

8 November 2025

Background: Complicated pneumonia (CP) in children presents in various forms—including empyema, necrotizing pneumonia (NP), necrotizing pneumonia with pleural effusion (NP + PE), and parapneumonic pleural effusion (PPE)—and is associated...

(This article belongs to the Section Respiratory Diseases)
  • Review
  • Open Access
3 Citations
6,784 Views
38 Pages

Research Progress on the Efficacy and Mechanism of Acupuncture in Treating Chronic Gastritis

  • Jing He,
  • Hongye Wang,
  • Cong Che,
  • Anjie Wang,
  • Ru Nie,
  • Jinghong Tan,
  • Jialin Jia,
  • Zijian Liu,
  • Tie Li and
  • Guojuan Dong

7 November 2025

Chronic gastritis (CG) is a prevalent digestive disorder. It progresses through multiple stages, has an insidious onset, and can lead to severe complications if untreated. Modern treatments primarily aim to eradicate Helicobacter pylori and relieve s...

  • Article
  • Open Access
2 Citations
1,770 Views
13 Pages

Blood Urea/Creatinine Ratio and Mortality in Ambulatory Patients with Heart Failure with Reduced Ejection Fraction

  • Andrew S. Oswald,
  • Muhammad S. Hussain,
  • Mohsin H. K. Roshan,
  • Filippo Pigazzani,
  • Anna-Maria Choy,
  • Faisel Khan,
  • Ify R. Mordi and
  • Chim C. Lang

7 November 2025

Background: Chronic heart failure with reduced ejection fraction (HFrEF) is associated with high mortality, and renal dysfunction is common in these patients. Blood urea/creatinine ratio (UCR) has been identified as a potential prognostic marker, ref...

(This article belongs to the Special Issue Insights into the Management of Cardiovascular Disease Risk Factors)
  • Article
  • Open Access
1 Citations
1,337 Views
9 Pages

Psychiatric Comorbidities in Parkinson’s Disease: A Moroccan Perspective on Anxiety and Depression

  • Khaoula Elcadi,
  • Oussama Cherkaoui Rhazouani,
  • Nissrine Louhab,
  • Najib Kissani and
  • Mohamed Chraa

6 November 2025

Background/Objectives: An individual’s quality of life is greatly impacted by the motor and non-motor symptoms of Parkinson’s disease (PD), which include anxiety and depression. Using the Hospital Anxiety and Depression Scale (HADS), this...

(This article belongs to the Special Issue Research Progress in Neurodegenerative Diseases)
  • Article
  • Open Access
1,548 Views
20 Pages

MicroRNA Signatures in Serous Ovarian Cancer: A Comparison of Prognostic Marker Targets in African Americans and Caucasians

  • Jane M. Muinde,
  • Celina Romi Yamauchi,
  • Joseph Cruz,
  • Alena A. McQuarter,
  • Kyah Miller,
  • Umang Sharma,
  • Skyler Schiff,
  • Isaac Kremsky,
  • Saied Mirshahidi and
  • Salma Khan
  • + 1 author

6 November 2025

Background: Ovarian cancer (OC) is the second most common gynecologic malignancy in the United States and remains the leading cause of death among cancers of the female reproductive system. Alarmingly, mortality rates have risen disproportionately am...

  • Review
  • Open Access
13 Citations
10,555 Views
27 Pages

Type 3 Diabetes: Linking Insulin Resistance to Cognitive Decline

  • Brooke Chapple,
  • Emily Bayliss,
  • Seth Woodfin,
  • Merritt Smith,
  • Jeremiah Winter and
  • William Moore

5 November 2025

Type 3 diabetes (T3D) is characterized by chronic insulin resistance and insulin deficiency in the brain, leading to neuronal death, inflammation, oxidative stress, apoptosis, and synaptic dysfunction. These pathological processes contribute to cogni...

(This article belongs to the Special Issue Research Progress in Neurodegenerative Diseases)
  • Case Report
  • Open Access
2 Citations
3,165 Views
14 Pages

Intraoral Epidermoid Cyst: Case Report and Literature Review

  • Ana Andabak Rogulj,
  • Danica Vidović Juras,
  • Božana Lončar Brzak,
  • Ivana Škrinjar,
  • Bruno Špiljak and
  • Sven Seiwerth

5 November 2025

Background/Objectives: Epidermoid cysts are benign lesions originating from germinative epithelium, characterized by a keratin-filled cavity. They are histopathologically classified as epidermoid, dermoid, or teratoid. Intraoral cases are exceedingly...

  • Case Report
  • Open Access
2 Citations
1,385 Views
9 Pages

4 November 2025

Immune checkpoint inhibitors (ICIs) and thoracic radiotherapy are standard treatments for advanced non-small-cell lung cancer (NSCLC), especially in patients with high PD-L1 expression or symptoms such as superior vena cava syndrome (SVCS). Both ther...

(This article belongs to the Section Oncology)
  • Article
  • Open Access
1,278 Views
15 Pages

Global Epidemiology of Smoking and Liver Cancer from 1990 to 2021

  • Jinguo Wang,
  • Yang Ma,
  • Aixu Duan and
  • Xiaoming Fan

3 November 2025

Liver cancer is a prevalent and highly malignant tumor worldwide, and smoking has been suggested as a potentially significant risk factor, but this association remains understudied and not widely recognized. This study utilized global epidemiological...

(This article belongs to the Topic Dietary Habits in Liver Health and Disease: Preclinical and Clinical Studies)
  • Review
  • Open Access
7 Citations
7,715 Views
18 Pages

Navigating the Latest Hepatitis B Virus Reactivation Guidelines

  • Zeyad Elharabi,
  • Jowana Saba and
  • Hakan Akin

1 November 2025

Hepatitis B virus (HBV) infection is a global health concern with an estimated 254 million people with chronic HBV infection. The utilization of immunosuppressive therapies (ISTs) is increasing and expanding continuously with new agents being impleme...

(This article belongs to the Special Issue Viral Hepatitis: Diagnosis, Treatment and Management)
  • Review
  • Open Access
22 Citations
7,401 Views
20 Pages

The Systemic Link Between Oral Health and Cardiovascular Disease: Contemporary Evidence, Mechanisms, and Risk Factor Implications

  • Florinel Cosmin Bida,
  • Florin Razvan Curca,
  • Raoul-Vasile Lupusoru,
  • Dragos Ioan Virvescu,
  • Mihaela Scurtu,
  • Gabriel Rotundu,
  • Oana Maria Butnaru,
  • Teona Tudorici,
  • Ionut Luchian and
  • Dana Gabriela Budala

31 October 2025

Background: Oral health plays a critical role in systemic wellbeing, with growing evidence supporting strong associations between oral conditions and cardiovascular disease (CVD). These connections extend beyond periodontal disease and involve oral m...

(This article belongs to the Special Issue Insights into the Management of Cardiovascular Disease Risk Factors)
  • Article
  • Open Access
1 Citations
685 Views
15 Pages

31 October 2025

Background: Centralization and certification mark constant processes in everyday clinical routine. Despite the continuously rising number of certified pancreatic cancer (PAC) centers in recent years, fewer than 40% of PAC resections are still perform...

(This article belongs to the Section Oncology)
  • Article
  • Open Access
1 Citations
8,757 Views
14 Pages

29 October 2025

Purpose: To assess the association between hair loss in females and various biomarkers including hemoglobin, iron, ferritin, zinc, selenium, calcium, vitamin D, vitamin B12, folic acid, and thyroid hormones. Patients and methods: This study enrolled...

  • Article
  • Open Access
1,500 Views
14 Pages

27 October 2025

Objectives: Hip fractures associated with osteoporosis are indicative of high rates of both disability and mortality. The objective of this study was to analyze the risk factors for recurrent hip fractures following primary osteoporotic hip fracture...

  • Article
  • Open Access
4 Citations
1,796 Views
17 Pages

Proportion and Correlates of Psychiatric Morbidity Among Psychiatry-Assessed Oncology Inpatients

  • Ana-Maria Paslaru,
  • Iulian Bounegru,
  • Catalin Plesea-Condratovici,
  • Moroianu Marius and
  • Anamaria Ciubară

24 October 2025

Background/Objectives: Psychiatric morbidity is frequent in oncology, yet prevalence and correlates differ across tumour sites. Urogenital cancers, in particular, involve psychosocial stressors related to sexuality, fertility, continence, and body im...

(This article belongs to the Special Issue Mental Health—Management and Care, Multidisciplinary Approaches and Perspectives)
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Diseases - ISSN 2079-9721