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Antibiotics, Volume 14, Issue 4

April 2025 - 94 articles

Cover Story: Antimicrobial peptides (AMPs) have emerged as promising agents for treating topical infections due to their enhanced biocompatibility and resistance to systemic degradation. AMPs possess immunomodulatory effects on the host and can disrupt bacterial cell membranes, a mechanism that is less prone to microbial resistance compared to conventional antibiotics, making AMPs potential candidates for antimicrobial delivery. Conventional AMP delivery systems, including polymeric, synthetic, and lipid-based nanoparticles and cubosomes, face challenges from microbial resistance mechanisms, including efflux pump systems, bacterial cell membrane modifications, and protease enzyme release. This review reinforces the need for optimization strategies to improve the current AMP-derived formulations in topical infections. View this paper
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Articles (94)

  • Article
  • Open Access
2 Citations
2,181 Views
20 Pages

Background/Objectives: Length of hospital stay (LOS) is a critical measure of healthcare efficiency. This study investigated factors contributing to prolonged LOS in adult patients with urinary tract infections (UTIs) in Lebanon and assessed microbia...

  • Protocol
  • Open Access
2,464 Views
16 Pages

Antimicrobial Dosing During Continuous Venovenous Hemodiafiltration in Septic Shock Patients: A Prospective, Multicenter Study Protocol

  • Alicia Wendy Vega Harwood,
  • Marta Martín Fernández,
  • Carlos Ezquer Garin,
  • Francisco Javier Álvarez,
  • Rocío López Herrero,
  • Eduardo Tamayo and
  • Gerardo Aguilar

Background: Sepsis is a major global health issue and the leading cause of death in critically ill patients, with rising incidence and associated healthcare costs. Early administration of antibiotic therapy is crucial, but increasing antibiotic resis...

  • Article
  • Open Access
1 Citations
1,223 Views
25 Pages

Background/Objectives: Since 28 January 2022, veterinary medicinal products (VMPs) must be used in accordance with the conditions of the marketing authorisation (Regulation (EU) 2019/6, Article 106). This entails further restrictions on therapeutic f...

  • Article
  • Open Access
2 Citations
1,409 Views
14 Pages

Cranberry-Derived Phenolic Compounds Contribute to the Inhibition of FimH-Mediated Escherichia coli Hemagglutination

  • Rosana Ribić,
  • Vesna Petrović Peroković,
  • Tomislav Meštrović,
  • Marijana Neuberg and
  • Nikola Bradić

Background/Objectives: FimH adhesin, located at the tips of type 1 pili in Escherichia coli (E. coli), plays a crucial role in bacterial adhesion to the surface urothelial cells—a key step in the pathogenesis of urinary tract infections (UTIs)....

  • Article
  • Open Access
1 Citations
1,408 Views
14 Pages

Background: As a broad-spectrum fluoroquinolone, enrofloxacin (ENR) is commonly employed to manage bacterial infections in aquatic species. Nevertheless, there have been no documented pharmacokinetic and residue studies conducted on Dybowski’s...

  • Case Report
  • Open Access
1,035 Views
19 Pages

Background Members of the Mycobacterium avium complex (MAC) have been documented to cause severe and disseminated infections in dogs, although such cases are sporadically reported. In this study, a comprehensive account of a rare case of generalised...

  • Article
  • Open Access
1,327 Views
25 Pages

In Vitro Evaluation of the Antibacterial Effect and Influence on the Bacterial Biofilm Formation of Glutamic Acid and Some Structural Analogues

  • Octavia-Laura Oancea,
  • Cristina Nicoleta Ciurea,
  • Anca Delia Mare,
  • Adrian Man,
  • Ruxandra Stefanescu and
  • Aura Rusu

Background/Objectives: Glutamic acid (GLA) is an essential amino acid with a key role in human metabolism. A potential involvement in anticancer therapy and possible antibacterial and anti-biofilm effects were also observed. Glutamine (GLN) and monos...

  • Review
  • Open Access
3 Citations
3,142 Views
17 Pages

Antimicrobial resistance is already a major global health threat, contributing to nearly 5 million deaths annually. The rise of multidrug-resistant pathogens has made many infections increasingly difficult to treat. This growing threat has driven the...

  • Article
  • Open Access
1,326 Views
19 Pages

Background: The global spread of antimicrobial resistance (AMR) remains one of the greatest challenges of our time, necessitating collaboration among professionals in both the animal and public health sectors. One bacterial species that is developing...

  • Article
  • Open Access
1 Citations
1,090 Views
19 Pages

Synergistic Effect of Bacillus and Chitosan: From Flocculation to Enhanced Antimicrobial Activity

  • Selena Dmitrović,
  • Nataša Lukić,
  • Ivana Danilov,
  • Vanja Vlajkov,
  • Jovana Grahovac and
  • Aleksandar Jokić

Eco-friendly pest management solutions are acknowledged as a crucial element in shaping the future of agriculture through sustainable practices. Achieving the maximum viable cell concentration while being cost-effective is the main goal of the downst...

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Antibiotics - ISSN 2079-6382