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Antibiotics
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Antibiotic Resistance and the Responsible Use of Antibiotics in Human...
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Antibiotic Resistance and the Responsible Use of Antibiotics in Human and Veterinary Medicine

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: closed (30 April 2025) | Viewed by 2424

Special Issue Editors

Prof. Dr. Horvat Olga

E-Mail Website
Guest Editor
Department of Pharmacology Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia
Interests: consumption and rational use of antibiotics; antimicrobial resistance; pharmacoepidemiological studies
Prof. Dr. Frane Božić

E-Mail Website
Co-Guest Editor
Department for Pharmacology and Toxicology, Veterinary Faculty, University of Zagreb, Zagreb, Croatia
Interests: one health; antimicrobial resistance; immunopharmacology

Special Issue Information

Dear Colleagues,

Antimicrobial resistance (AMR) is widely recognized as a critical public health challenge in both human and veterinary medicine. AMR spread is a complex issue, as there are numerous ways through which it can be transferred between humans and animals, including via close contact, the food chain, or, indirectly, the environment. Antibiotic misuse in human healthcare, veterinary practice, and livestock farming is the primary driver of this problem. This is particularly concerning because the antimicrobials used in human medicine are often similar to those used in veterinary medicine, meaning that antibiotics which are critically important for human health should be avoided whenever possible. In response, the World Health Assembly has adopted five key strategic action plans to combat AMR: (1) enhancing AMR awareness and understanding; (2) strengthening knowledge through surveillance and research, with a focus on infection control measures; (3) implementing effective sanitation, hygiene, and infection prevention strategies; (4) optimizing antimicrobial use in both human and animal health; and (5) ensuring sustainable investment in countering antimicrobial resistance. Therefore, this Special Issue invites submissions from various research fields that focus on AMR and antimicrobial use in both human and veterinary medicine, with a particular focus on the World Health Assembly's five objectives.

Prof. Dr. Horvat Olga
Prof. Dr. Frane Božić
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antibiotics
  • antimicrobial resistance
  • human medicine
  • veterinary medicine
  • infection

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Published Papers (2 papers)

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Research

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13 pages, 737 KiB  
Article
Influence of N-Acetyl-L-Cysteine on the Pharmacokinetics and Antibacterial Activity of Marbofloxacin in Chickens
by Albena Roydeva, Nikolina Rusenova and Aneliya Milanova
Antibiotics 2025, 14(4), 393; https://doi.org/10.3390/antibiotics14040393 - 10 Apr 2025
Viewed by 290
Abstract
Background/Objectives: Marbofloxacin, a second-generation fluoroquinolone, is used to control economically significant poultry diseases caused by pathogenic bacteria such as Staphylococcus aureus and Escherichia coli. Although synergistic antimicrobial activity between fluoroquinolones and N-acetyl-L-cysteine (NAC) has been observed in vitro, data on their [...] Read more.
Background/Objectives: Marbofloxacin, a second-generation fluoroquinolone, is used to control economically significant poultry diseases caused by pathogenic bacteria such as Staphylococcus aureus and Escherichia coli. Although synergistic antimicrobial activity between fluoroquinolones and N-acetyl-L-cysteine (NAC) has been observed in vitro, data on their pharmacokinetic interactions in vivo remain limited. This study aimed to evaluate the effect of NAC on the oral pharmacokinetics of marbofloxacin in broiler chickens and its antibacterial activity against E. coli ATCC 25922 and S. aureus ATCC 25923, assessing the potential benefits of their combined administration. Methods: The pharmacokinetics of marbofloxacin was evaluated in broilers (5 mg/kg dose) after a single intravenous (n = 12) or single oral (n = 12) administration into the crop. The protocol for the co-administration of marbofloxacin and NAC (400 mg/kg via feed) was as follows: on the first day, the poultry (n = 12) received a single oral dose of marbofloxacin via the crop and over the next four days the fluoroquinolone drug was administered via their drinking water. The plasma levels of the drugs were determined using LC-MS/MS analyses, and minimum inhibitory concentrations were determined using the microbroth dilution method. Results: NAC significantly reduced the bioavailability of marbofloxacin after a single oral administration into the crop and decreased the elimination rate constant following the administration of both drugs. At a concentration of 20 μg/mL, NAC led to a 3.8-fold reduction in the MIC of marbofloxacin against E. coli ATCC 25922 and a 2-fold decrease at concentrations between 1 μg/mL and 6 μg/mL, while no change was observed in marbofloxacin’s effect on S. aureus ATCC 25923. Conclusions: Oral co-administration of NAC and marbofloxacin reduced the fluoroquinolone’s bioavailability by two-fold while enhancing its antibacterial activity against E. coli ATCC 25922. Full article
(This article belongs to the Special Issue Antibiotic Resistance and the Responsible Use of Antibiotics in Human and Veterinary Medicine)
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Review

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21 pages, 351 KiB  
Review
Human and Veterinary Medicine Collaboration: Synergistic Approach to Address Antimicrobial Resistance Through the Lens of Planetary Health
by Olga Horvat and Zorana Kovačević
Antibiotics 2025, 14(1), 38; https://doi.org/10.3390/antibiotics14010038 - 6 Jan 2025
Cited by 1 | Viewed by 1841
Abstract
Antimicrobial resistance (AMR) represents a critical threat to human, animal, and environmental health, challenging global efforts to maintain sustainable ecosystems and public health systems. In this review, the complex, cross-disciplinary issues of AMR are explored within the framework of planetary health, emphasizing the [...] Read more.
Antimicrobial resistance (AMR) represents a critical threat to human, animal, and environmental health, challenging global efforts to maintain sustainable ecosystems and public health systems. In this review, the complex, cross-disciplinary issues of AMR are explored within the framework of planetary health, emphasizing the interconnectedness of human and veterinary medicine with broader environmental and social systems. Specifically, it addresses the social, economic, environmental, and health dimensions of AMR under the planetary health framework. The social aspects consider how public awareness, education, and healthcare practices shape antimicrobial use (AMU) and resistance patterns. The economic impact evaluates the cost burdens of AMR, including healthcare costs, loss of productivity, and the implications for the livestock and food production industries. The environmental dimension highlights the role of pharmaceutical waste, agricultural runoff, and industrial pollution in contributing to the spread of antimicrobials and resistant pathogens in ecosystems. To illustrate these challenges, a comprehensive literature review using the PubMed and Web of Science databases was conducted, identifying 91 relevant articles on planetary health and AMR. In this review, the knowledge from these studies and additional references is integrated to provide a holistic overview of the AMR crisis. By applying the four pillars of planetary health—social, economic, environmental, and health knowledge—in this manuscript, the necessity is underscored of collaborative strategies across human and veterinary medicine to combat AMR. Ultimately, this synergistic approach aims to shape the policies and practices that safeguard public health, protect ecosystems, and promote a sustainable future by implementing antimicrobial stewardship programs and encouraging prudent AMU. Full article
(This article belongs to the Special Issue Antibiotic Resistance and the Responsible Use of Antibiotics in Human and Veterinary Medicine)
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