Special Issue "Development of Bacteriophage Derived Lysins and Depolymerases for Therapeutic Purposes in Combating Bacterial Pathogens"
Deadline for manuscript submissions: 30 April 2021.
Bacterial infections have been increasing over the years, being considered as a huge health problem worldwide. This is particularly due to the increase in the resistance to antibiotics, which lead to less effective treatments. Consequently, new strategies are needed to control multi-drug resistant bacteria.
Bacteriophage-derived proteins can be seen as an appealing alternative treatment. Bacteriophages are viruses that encode several specialized proteins that break down several host carbohydrate barriers, allowing them to enter, replicate and lyse their bacterial hosts. First, polysaccharide depolymerases degrade capsules, lipopolysaccharides or exopolysaccharides, allowing phages to reach the inner cell layers. Second, virion-associated lysins come into play by locally degrading the peptidoglycan, enabling phages to inject their DNA inside the cell and replicate. Finally, endolysins are produced at the end of the phage lytic cycle to quickly degrade the peptidoglycan, causing the cells to burst and the progeny to be subsequently released.
This Special Issue seeks manuscript submissions that further our understanding of how these enzymes could be used to target different bacterial polysaccharides (capsules, lipopolysaccharides, exopolysaccharides and peptidoglycan), to control bacterial pathogens in food, veterinary and human medicine.
Dr. Hugo Oliveira
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Virion-assiociated lysins
- Polysaccharide depolymerases
- Bacterial infections