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Biosensors, Volume 11, Issue 2

2021 February - 32 articles

Cover Story: The measurement of the chemical parameters of binding between cell adhesion molecules and extracellu-lar ligands using live-cell assays is a challenging task. Here, for the first time, we used a computer-controlled micropipette to measure cell adhesion on PLL-g-PEG-based surface coatings with various ligand densities to determine the dissociation constant of the integrin–RGD bond. We use a simple biophysical model to fit the weighted average of adhesion histograms. The results are confirmed by applying a resonant waveguide-based biosensor. Furthermore, we present a subpopulation analysis of the data emphasizing the single-cell capabili-ties of the method. We find that most cells are found in the weak adhesion range, while a growing, strongly adhered subpopulation appears with the increase of RGD surface density. View this paper.
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Articles (32)

  • Review
  • Open Access
54 Citations
8,673 Views
32 Pages

Fiber Optic Sensors for Vital Signs Monitoring. A Review of Its Practicality in the Health Field

  • Christian Perezcampos Mayoral,
  • Jaime Gutiérrez Gutiérrez,
  • José Luis Cano Pérez,
  • Marciano Vargas Treviño,
  • Itandehui Belem Gallegos Velasco,
  • Pedro António Hernández Cruz,
  • Rafael Torres Rosas,
  • Lorenzo Tepech Carrillo,
  • Judith Arnaud Ríos and
  • Roberto Rojas Laguna
  • + 1 author

23 February 2021

Vital signs not only reflect essential functions of the human body but also symptoms of a more serious problem within the anatomy; they are well used for physical monitoring, caloric expenditure, and performance before a possible symptom of a massive...

  • Article
  • Open Access
5 Citations
2,848 Views
11 Pages

21 February 2021

Microbial reactor sensors (based on freshly harvested intact microbial cells) or microbial membrane sensors (based on immobilized microbial cells) can be used as convenient instruments for studying processes that cause the response of a biosensor, su...

  • Article
  • Open Access
14 Citations
4,859 Views
20 Pages

Electrical Characterization of Cellulose-Based Membranes towards Pathogen Detection in Water

  • Grégoire Le Brun,
  • Margo Hauwaert,
  • Audrey Leprince,
  • Karine Glinel,
  • Jacques Mahillon and
  • Jean-Pierre Raskin

21 February 2021

Paper substrates are promising for development of cost-effective and efficient point-of-care biosensors, essential for public healthcare and environmental diagnostics in emergency situations. Most paper-based biosensors rely on the natural capillarit...

  • Review
  • Open Access
86 Citations
9,633 Views
24 Pages

Recent Advances in Nanotechnology-Based Diagnosis and Treatments of Human Osteosarcoma

  • Mahmood Barani,
  • Mahwash Mukhtar,
  • Abbas Rahdar,
  • Saman Sargazi,
  • Sadanand Pandey and
  • Misook Kang

20 February 2021

Osteosarcoma (OSA) is a type of bone cancer that begins in the cells that form bones. OSA is a rare mesenchymal bone neoplasm derived from mesenchymal stem cells. Genome disorganization, chromosomal modifications, deregulation of tumor suppressor gen...

  • Article
  • Open Access
14 Citations
3,231 Views
11 Pages

19 February 2021

This research reports a portable immunochip, based on quartz crystal microbalance (QCM) for label-free, low-cost qualitative detection of zearalenone (ZEN) in food samples. The experimental parameters in the functionalization and working process were...

  • Article
  • Open Access
12 Citations
4,744 Views
11 Pages

19 February 2021

In this report, we summarized our development of biosensors for Rhodamine 6G and in vitro glucose detection based on surface-enhanced Raman scattering technology. For the detection of both Rhodamine 6G and in vitro glucose, a nature-patterned substra...

  • Article
  • Open Access
7 Citations
3,176 Views
13 Pages

A Useful Combination of Quantitative Ultrashort Echo Time MR Imaging and a Probing Device for Biomechanical Evaluation of Articular Cartilage

  • Takehito Hananouchi,
  • Yanjun Chen,
  • Saeed Jerban,
  • Masaru Teramoto,
  • Yajun Ma,
  • Erik W. Dorthe,
  • Eric Y. Chang,
  • Jiang Du and
  • Darryl D. D’Lima

17 February 2021

In this study, we combined quantitative ultrashort echo time (UTE) magnetic resonance (MR) imaging and an investigation by a probing device with tri-axial force sensor to seek correlations with mechanical properties of human patellar cartilage for in...

  • Article
  • Open Access
26 Citations
4,686 Views
18 Pages

Dielectrophoretic Characterization of Tenogenically Differentiating Mesenchymal Stem Cells

  • Anthony T. Giduthuri,
  • Sophia K. Theodossiou,
  • Nathan R. Schiele and
  • Soumya K. Srivastava

16 February 2021

Tendons are collagenous musculoskeletal tissues that connect muscles to bones and transfer the forces necessary for movement. Tendons are susceptible to injury and heal poorly, with long-term loss of function. Mesenchymal stem cell (MSC)-based therap...

  • Review
  • Open Access
100 Citations
13,920 Views
23 Pages

16 February 2021

Screen-printed technology has helped considerably to the development of portable electrochemical sensors since it provides miniaturized but robust and user-friendly electrodes. Moreover, this technology allows to obtain very versatile transducers, no...

  • Communication
  • Open Access
43 Citations
9,742 Views
12 Pages

14 February 2021

This paper presents a lateral flow assay (LFA) for the quantitative, fluorescence-based detection of the cardiac biomarker troponin I (cTnI) that features an analytical strip made of cellulose filter paper. The results show that the wicking and test...

  • Review
  • Open Access
27 Citations
9,074 Views
27 Pages

Nucleic Acid-Based Sensing Techniques for Diagnostics and Surveillance of Influenza

  • Samantha J. Courtney,
  • Zachary R. Stromberg and
  • Jessica Z. Kubicek-Sutherland

12 February 2021

Influenza virus poses a threat to global health by causing seasonal outbreaks as well as three pandemics in the 20th century. In humans, disease is primarily caused by influenza A and B viruses, while influenza C virus causes mild disease mostly in c...

  • Perspective
  • Open Access
19 Citations
7,493 Views
13 Pages

12 February 2021

Halophilic bacteria are remarkable organisms that have evolved strategies to survive in high saline concentrations. These bacteria offer many advances for microbial-based biotechnologies and are commonly used for industrial processes such as compatib...

  • Article
  • Open Access
7 Citations
2,915 Views
9 Pages

Simple Yeast-Direct Catalytic Fuel Cell Bio-Device: Analytical Results and Energetic Properties

  • Mauro Tomassetti,
  • Emanuele Dell’Aglio,
  • Mauro Castrucci,
  • Maria Pia Sammartino,
  • Luigi Campanella and
  • Corrado Di Natale

11 February 2021

This paper reports the analytical detection and energetic properties of a glucose-fed Direct Catalytic Fuel Cell (DCFC) operated in association with yeast cells (Saccharomyces Cerevisiae). The cell was tested in a potentiostatic mode, and the operati...

  • Review
  • Open Access
31 Citations
5,406 Views
28 Pages

Imprinted Polymers as Synthetic Receptors in Sensors for Food Safety

  • Rocio Arreguin-Campos,
  • Kathia L. Jiménez-Monroy,
  • Hanne Diliën,
  • Thomas J. Cleij,
  • Bart van Grinsven and
  • Kasper Eersels

11 February 2021

Foodborne illnesses represent high costs worldwide in terms of medical care and productivity. To ensure safety along the food chain, technologies that help to monitor and improve food preservation have emerged in a multidisciplinary context. These te...

  • Article
  • Open Access
27 Citations
4,694 Views
15 Pages

10 February 2021

An origami three-dimensional design of a paper-based potentiometric sensor is described. In its simplest form, this electrochemical paper-based analytical device (ePAD) is made from three small parts of the paper. Paper layers are folded on each othe...

  • Article
  • Open Access
20 Citations
4,711 Views
11 Pages

A Novel Enzyme-Based SPR Strategy for Detection of the Antimicrobial Agent Chlorophene

  • Gabriela Elizabeth Quintanilla-Villanueva,
  • Donato Luna-Moreno,
  • Edgar Allan Blanco-Gámez,
  • José Manuel Rodríguez-Delgado,
  • Juan Francisco Villarreal-Chiu and
  • Melissa Marlene Rodríguez-Delgado

9 February 2021

Chlorophene is an important antimicrobial agent present in disinfectant products which has been related to health and environmental effects, and its detection has been limited to chromatographic techniques. Thus, there is a lack of research that atte...

  • Article
  • Open Access
21 Citations
5,194 Views
15 Pages

Optimisation of an Electrochemical DNA Sensor for Measuring KRAS G12D and G13D Point Mutations in Different Tumour Types

  • Bukola Attoye,
  • Matthew J. Baker,
  • Fiona Thomson,
  • Chantevy Pou and
  • Damion K. Corrigan

5 February 2021

Circulating tumour DNA (ctDNA) is widely used in liquid biopsies due to having a presence in the blood that is typically in proportion to the stage of the cancer and because it may present a quick and practical method of capturing tumour heterogeneit...

  • Article
  • Open Access
23 Citations
6,027 Views
12 Pages

2D Nanomaterial, Ti3C2 MXene-Based Sensor to Guide Lung Cancer Therapy and Management

  • Mahek Sadiq,
  • Lizhi Pang,
  • Michael Johnson,
  • Venkatachalem Sathish,
  • Qifeng Zhang and
  • Danling Wang

4 February 2021

Major advances in cancer control can be greatly aided by early diagnosis and effective treatment in its pre-invasive state. Lung cancer (small cell and non-small cell) is a leading cause of cancer-related deaths among both men and women around the wo...

  • Review
  • Open Access
14 Citations
4,814 Views
16 Pages

Ethanol Biofuel Cells: Hybrid Catalytic Cascades as a Tool for Biosensor Devices

  • Jefferson Honorio Franco,
  • Shelley D. Minteer and
  • Adalgisa R. De Andrade

4 February 2021

Biofuel cells use chemical reactions and biological catalysts (enzymes or microorganisms) to produce electrical energy, providing clean and renewable energy. Enzymatic biofuel cells (EBFCs) have promising characteristics and potential applications as...

  • Review
  • Open Access
29 Citations
8,759 Views
18 Pages

31 January 2021

Cyclic adenosine monophosphate (cAMP) plays a key role in signal transduction pathways as a second messenger. Studies on the cAMP dynamics provided useful scientific insights for drug development and treatment of cAMP-related diseases such as some ca...

  • Article
  • Open Access
6 Citations
3,614 Views
16 Pages

29 January 2021

Surface-enhanced Raman scattering (SERS) nanoprobes have shown tremendous potential in in vivo imaging. The development of single oligomer resolution in the SERS promotes experiments on DNA and protein identification using SERS as a nanobiosensor. As...

  • Perspective
  • Open Access
22 Citations
8,377 Views
10 Pages

Space Biology Research and Biosensor Technologies: Past, Present, and Future

  • Ada Kanapskyte,
  • Elizabeth M. Hawkins,
  • Lauren C. Liddell,
  • Shilpa R. Bhardwaj,
  • Diana Gentry and
  • Sergio R. Santa Maria

29 January 2021

In light of future missions beyond low Earth orbit (LEO) and the potential establishment of bases on the Moon and Mars, the effects of the deep space environment on biology need to be examined in order to develop protective countermeasures. Although...

  • Article
  • Open Access
16 Citations
5,720 Views
13 Pages

Development of Smart-Ring-Based Chest Compression Depth Feedback Device for High Quality Chest Compressions: A Proof-of-Concept Study

  • Seungjae Lee,
  • Yeongtak Song,
  • Jongshill Lee,
  • Jaehoon Oh,
  • Tae Ho Lim,
  • Chiwon Ahn and
  • In Young Kim

28 January 2021

Recently, a smart-device-based chest compression depth (CCD) feedback system that helps ensure that chest compressions have adequate depth during cardiopulmonary resuscitation (CPR) was developed. However, no CCD feedback device has been developed fo...

  • Article
  • Open Access
14 Citations
4,736 Views
15 Pages

Investigation of L-Tryptophan Electrochemical Oxidation with a Graphene-Modified Electrode

  • Florina Pogacean,
  • Codruta Varodi,
  • Maria Coros,
  • Irina Kacso,
  • Teodora Radu,
  • Bogdan Ionut Cozar,
  • Valentin Mirel and
  • Stela Pruneanu

28 January 2021

A graphene sample (EGr) was prepared by electrochemical exfoliation of graphite rods in solution containing 0.05 M (NH4)2SO4 + 0.1 M H3BO3 + 0.05 M NaCl. The exfoliation was performed by applying a constant voltage (12 V) between the graphite rods, w...

  • Article
  • Open Access
42 Citations
5,687 Views
12 Pages

27 January 2021

Worldwide infection disease due to SARS-CoV-2 is tremendously affecting our daily lives. High-throughput detection methods for nucleic acids are emergently desired. Here, we show high-sensitivity and high-throughput metasurface fluorescence biosensor...

  • Article
  • Open Access
5 Citations
5,067 Views
14 Pages

Water Sampling Module for Collecting and Concentrating Legionella pneumophila from Low-to-Medium Contaminated Environment

  • Khalid Moumanis,
  • Lilian Sirbu,
  • Walid Mohamed Hassen,
  • Eric Frost,
  • Lydston Rodrigues de Carvalho,
  • Pierre Hiernaux and
  • Jan Jerzy Dubowski

27 January 2021

The detection of water contamination with Legionella pneumophila is of critical importance to manufacturers of water processing equipment and public health entities dealing with water networks and distribution systems. Detection methods based on poly...

  • Review
  • Open Access
123 Citations
18,155 Views
41 Pages

Detection Technologies for Reactive Oxygen Species: Fluorescence and Electrochemical Methods and Their Applications

  • Surachet Duanghathaipornsuk,
  • Eveline J. Farrell,
  • Ana C. Alba-Rubio,
  • Piotr Zelenay and
  • Dong-Shik Kim

24 January 2021

Reactive oxygen species (ROS) have been found in plants, mammals, and natural environmental processes. The presence of ROS in mammals has been linked to the development of severe diseases, such as diabetes, cancer, tumors, and several neurodegenerati...

  • Systematic Review
  • Open Access
19 Citations
4,625 Views
12 Pages

Biosensors for Detection of Biochemical Markers Relevant to Osteoarthritis

  • Umile Giuseppe Longo,
  • Vincenzo Candela,
  • Alessandra Berton,
  • Sergio De Salvatore,
  • Sara Fioravanti,
  • Lucia Giannone,
  • Anna Marchetti,
  • Maria Grazia De Marinis and
  • Vincenzo Denaro

24 January 2021

This systematic review aimed to assess the advantages of biosensors in detecting biomarkers for the early diagnosis of osteoarthritis (OA). OA is the most prevalent musculoskeletal disease and is a leading cause of disability and pain worldwide. The...

  • Article
  • Open Access
11 Citations
6,467 Views
11 Pages

Dissociation Constant of Integrin-RGD Binding in Live Cells from Automated Micropipette and Label-Free Optical Data

  • Tamás Gerecsei,
  • Péter Chrenkó,
  • Nicolett Kanyo,
  • Beatrix Péter,
  • Attila Bonyár,
  • Inna Székács,
  • Balint Szabo and
  • Robert Horvath

24 January 2021

The binding of integrin proteins to peptide sequences such as arginine-glycine-aspartic acid (RGD) is a crucial step in the adhesion process of mammalian cells. While these bonds can be examined between purified proteins and their ligands, live-cell...

  • Article
  • Open Access
51 Citations
7,105 Views
13 Pages

A Paper-Based Colorimetric Aptasensor for the Detection of Gentamicin

  • Saipriya Ramalingam,
  • Christopher M. Collier and
  • Ashutosh Singh

21 January 2021

Antibiotics are classes of antimicrobial substances that are administered widely in the field of veterinary science to promote animal health and feed efficiency. Cattle-administered antibiotics hold a risk of passing active residues to milk, during t...

  • Article
  • Open Access
18 Citations
5,355 Views
15 Pages

Porous Silicon Biosensor for the Detection of Bacteria through Their Lysate

  • Roselien Vercauteren,
  • Audrey Leprince,
  • Jacques Mahillon and
  • Laurent A. Francis

20 January 2021

Porous silicon (PSi) has been widely used as a biosensor in recent years due to its large surface area and its optical properties. Most PSi biosensors consist in close-ended porous layers, and, because of the diffusion-limited infiltration of the ana...

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Biosensors - ISSN 2079-6374