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Biosensors, Volume 10, Issue 11

2020 November - 38 articles

Cover Story: The widespread adaptation of 3D printing in the microfluidic, bioelectronic, and Bio-MEMS communities has been stifled by the lack of investigation into the biocompatibility of commercially available printer resins. By introducing an in-depth post-printing treatment of these resins, their biocompatibility can be dramatically improved up to that of a standard cell culture vessel (99.99%). Additionally, encapsulating resins that are less biocompatible with materials that are common constituents in biosensors further enhances the biocompatibility of the material. This investigation provides a clear pathway toward developing fully functional and biocompatible 3D printed biosensor devices, especially for interfacing with electrogenic cells, utilizing benchtop-based microfabrication, and post-processing techniques. View this paper.
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Articles (38)

  • Article
  • Open Access
23 Citations
5,055 Views
14 Pages

Detection of Lethal Bronzing Disease in Cabbage Palms (Sabal palmetto) Using a Low-Cost Electronic Nose

  • Martin J. Oates,
  • Nawaf Abu-Khalaf,
  • Carlos Molina-Cabrera,
  • Antonio Ruiz-Canales,
  • Jose Ramos and
  • Brian W. Bahder

23 November 2020

Lethal Bronzing Disease (LB) is a disease of palms caused by the 16SrIV-D phytoplasma. A low-cost electronic nose (eNose) prototype was trialed for its detection. It includes an array of eight Taguchi-type (MQ) sensors (MQ135, MQ2, MQ3, MQ4, MQ5, MQ9...

  • Article
  • Open Access
45 Citations
7,116 Views
12 Pages

21 November 2020

Paper-based microfluidic analysis devices (μPADs) have attracted attention as a cost-effective platform for point-of-care testing (POCT), food safety, and environmental monitoring. Recently, three-dimensional (3D)-μPADs have been developed to i...

  • Review
  • Open Access
97 Citations
9,879 Views
20 Pages

Recent Advances in MXene Nanocomposite-Based Biosensors

  • Jinho Yoon,
  • Minkyu Shin,
  • Joungpyo Lim,
  • Ji-Young Lee and
  • Jeong-Woo Choi

20 November 2020

The development of advanced biosensors with high sensitivity and selectivity is one of the most demanded concerns in the field of biosensors. To meet this requirement, up until now, numerous nanomaterials have been introduced to develop biosensors fo...

  • Review
  • Open Access
128 Citations
13,291 Views
46 Pages

Electrochemical Biosensors for Detection of MicroRNA as a Cancer Biomarker: Pros and Cons

  • Maliana El Aamri,
  • Ghita Yammouri,
  • Hasna Mohammadi,
  • Aziz Amine and
  • Hafsa Korri-Youssoufi

20 November 2020

Cancer is the second most fatal disease in the world and an early diagnosis is important for a successful treatment. Thus, it is necessary to develop fast, sensitive, simple, and inexpensive analytical tools for cancer biomarker detection. MicroRNA (...

  • Review
  • Open Access
25 Citations
5,923 Views
19 Pages

19 November 2020

Whilst it is universally accepted that the energy support of the brain is glucose, the form in which the glucose is taken up by neurones is the topic of intense debate. In the last few decades, the concept of lactate shuttling between glial elements...

  • Article
  • Open Access
21 Citations
4,594 Views
14 Pages

Drug-Based Gold Nanoparticles Overgrowth for Enhanced SPR Biosensing of Doxycycline

  • Syed Akif Raza Kazmi,
  • Muhammad Zahid Qureshi and
  • Jean-Francois Masson

19 November 2020

In clinical chemistry, frequent monitoring of drug levels in patients has gained considerable importance because of the benefits of drug monitoring on human health, such as the avoidance of high risk of over dosage or increased therapeutic efficacy....

  • Article
  • Open Access
1 Citations
5,563 Views
28 Pages

Dual-Channel Stopped-Flow Apparatus for Simultaneous Fluorescence, Anisotropy, and FRET Kinetic Data Acquisition for Binary and Ternary Biological Complexes

  • Roberto F. Delgadillo,
  • Katie A. Carnes,
  • Nestor Valles-Villarreal,
  • Omar Olmos,
  • Kathia Zaleta-Rivera and
  • Lawrence J. Parkhurst

19 November 2020

The Stopped-Flow apparatus (SF) tracks molecular events by mixing the reactants in sub-millisecond regimes. The reaction of intrinsically or extrinsically labeled biomolecules can be monitored by recording the fluorescence, F(t), anisotropy, r(t), po...

  • Review
  • Open Access
148 Citations
25,261 Views
18 Pages

Surface Modification Techniques for Endothelial Cell Seeding in PDMS Microfluidic Devices

  • Fahima Akther,
  • Shazwani Binte Yakob,
  • Nam-Trung Nguyen and
  • Hang T. Ta

19 November 2020

Microfluidic lab-on-a-chip cell culture techniques have been gaining popularity by offering the possibility of reducing the amount of samples and reagents and greater control over cellular microenvironment. Polydimethylsiloxane (PDMS) is the commonly...

  • Article
  • Open Access
10 Citations
4,959 Views
16 Pages

19 November 2020

Rapid antimicrobial susceptibility testing (AST) is an effective measure in the treatment of infections and the prevention of bacterial drug resistance. However, diverse antibiotic types and bacterial characteristics have formed complicated barriers...

  • Review
  • Open Access
29 Citations
6,387 Views
24 Pages

State-of-the-Art Optical Microfiber Coupler Sensors for Physical and Biochemical Sensing Applications

  • Maolin Dai,
  • Zhenmin Chen,
  • Yuanfang Zhao,
  • Manthangal Sivanesan Aruna Gandhi,
  • Qian Li and
  • Hongyan Fu

18 November 2020

An optical fiber coupler is a simple and fundamental component for fiber optic technologies that works by reducing the fiber diameter to hundred nanometers or several micrometers. The microfiber coupler (MFC) has regained interest in optical fiber se...

  • Article
  • Open Access
15 Citations
4,318 Views
13 Pages

Newly Developed System for the Robust Detection of Listeria monocytogenes Based on a Bioelectric Cell Biosensor

  • Agni Hadjilouka,
  • Konstantinos Loizou,
  • Theofylaktos Apostolou,
  • Lazaros Dougiakis,
  • Antonios Inglezakis and
  • Dimitrios Tsaltas

17 November 2020

Human food-borne diseases caused by pathogenic bacteria have been significantly increased in the last few decades causing numerous deaths worldwide. The standard analyses used for their detection have significant limitations regarding cost, special f...

  • Communication
  • Open Access
26 Citations
6,144 Views
8 Pages

Microfluidic Packaging Integration with Electronic-Photonic Biosensors Using 3D Printed Transfer Molding

  • Christos Adamopoulos,
  • Asmaysinh Gharia,
  • Ali Niknejad,
  • Vladimir Stojanović and
  • Mekhail Anwar

14 November 2020

Multiplexed sensing in integrated silicon electronic-photonic platforms requires microfluidics with both high density micro-scale channels and meso-scale features to accommodate for optical, electrical, and fluidic coupling in small, millimeter-scale...

  • Article
  • Open Access
28 Citations
6,641 Views
13 Pages

Electrochemical Immunosensors Based on Screen-Printed Gold and Glassy Carbon Electrodes: Comparison of Performance for Respiratory Syncytial Virus Detection

  • Wioleta Białobrzeska,
  • Daniel Firganek,
  • Maciej Czerkies,
  • Tomasz Lipniacki,
  • Marta Skwarecka,
  • Karolina Dziąbowska,
  • Zofia Cebula,
  • Natalia Malinowska,
  • Daniel Bigus and
  • Dawid Nidzworski
  • + 4 authors

13 November 2020

This paper presents the development and comparison of label-free electrochemical immunosensors based on screen-printed gold and glassy carbon (GC) disc electrodes for efficient and rapid detection of respiratory syncytial virus (RSV). Briefly, the an...

  • Review
  • Open Access
16 Citations
4,767 Views
26 Pages

High-Tech and Nature-Made Nanocomposites and Their Applications in the Field of Sensors and Biosensors for Gas Detection

  • Daniele Zappi,
  • Matiss Martins Ramma,
  • Viviana Scognamiglio,
  • Amina Antonacci,
  • Gabriele Varani and
  • Maria Teresa Giardi

13 November 2020

Gas sensors have been object of increasing attention by the scientific community in recent years. For the development of the sensing element, two major trends seem to have appeared. On one hand, the possibility of creating complex structures at the n...

  • Article
  • Open Access
6 Citations
7,426 Views
10 Pages

Real-Time Optical Monitoring of Endotracheal Tube Displacement

  • Ramzan Ullah,
  • Karl Doerfer,
  • Pawjai Khampang,
  • Faraneh Fathi,
  • Wenzhou Hong,
  • Joseph E. Kerschner and
  • Bing Yu

12 November 2020

Proper ventilation of a patient with an endotracheal tube (ETT) requires proper placement of the ETT. We present a sensitive, noninvasive, operator-free, and cost-effective optical sensor, called Opt-ETT, for the real-time assessment of ETT placement...

  • Review
  • Open Access
21 Citations
5,899 Views
20 Pages

The Role of Electronic Noses in Phenotyping Patients with Chronic Obstructive Pulmonary Disease

  • Simone Scarlata,
  • Panaiotis Finamore,
  • Martina Meszaros,
  • Silvano Dragonieri and
  • Andras Bikov

11 November 2020

Chronic obstructive pulmonary disease (COPD) is a common progressive disorder of the respiratory system which is currently the third leading cause of death worldwide. Exhaled breath analysis is a non-invasive method to study lung diseases, and electr...

  • Article
  • Open Access
10 Citations
7,179 Views
17 Pages

11 November 2020

The PFPE–PEG–PFPE (Perfluoropolyether-polyethylene glycol-perfluoropolyether) surfactant has been used in droplet-based microfluidics and is known to provide high droplet stability and biocompatibility. Since this surfactant ensures the s...

  • Article
  • Open Access
11 Citations
3,983 Views
11 Pages

Electromagnetic Piezoelectric Acoustic Sensor Detection of Extracellular Vesicles through Interaction with Detached Vesicle Proteins

  • Loránd Románszki,
  • Zoltán Varga,
  • Judith Mihály,
  • Zsófia Keresztes and
  • Michael Thompson

11 November 2020

An electromagnetic piezoelectric acoustic sensor (EMPAS) was used to study the non-specific adsorption of human red blood cell-derived extracellular vesicle preparations. Vesicle storage history (temperature and duration) highly affected the obtained...

  • Review
  • Open Access
57 Citations
11,407 Views
29 Pages

Liquid Metal Based Flexible and Implantable Biosensors

  • Mingkuan Zhang,
  • Xiaohong Wang,
  • Zhiping Huang and
  • Wei Rao

10 November 2020

Biosensors are the core elements for obtaining significant physiological information from living organisms. To better sense life information, flexible biosensors and implantable sensors that are highly compatible with organisms are favored by researc...

  • Communication
  • Open Access
19 Citations
6,300 Views
7 Pages

8 November 2020

Single-molecule fluorescence energy transfer (FRET) detection has become a key technique to monitor intra- and intermolecular distance changes in biological processes. As the sensitive detection range of conventional FRET pairs is limited to 3–...

  • Article
  • Open Access
19 Citations
4,847 Views
18 Pages

Yeast-Based Fluorescent Sensors for the Simultaneous Detection of Estrogenic and Androgenic Compounds, Coupled with High-Performance Thin Layer Chromatography

  • Liat Moscovici,
  • Carolin Riegraf,
  • Nidaa Abu-Rmailah,
  • Hadas Atias,
  • Dror Shakibai,
  • Sebastian Buchinger,
  • Georg Reifferscheid and
  • Shimshon Belkin

8 November 2020

The persistence of endocrine disrupting compounds (EDCs) throughout wastewater treatment processes poses a significant health threat to humans and to the environment. The analysis of EDCs in wastewater remains a challenge for several reasons, includi...

  • Review
  • Open Access
38 Citations
10,487 Views
18 Pages

Interfacing DNA with Gold Nanoparticles for Heavy Metal Detection

  • Zhiyu He,
  • Huiling Yin,
  • Chia-Chen Chang,
  • Guoqing Wang and
  • Xingguo Liang

6 November 2020

The contamination of heavy metals (e.g., Hg, Pb, Cd and As) poses great risks to the environment and human health. Rapid and simple detection of heavy metals of considerable toxicity in low concentration levels is an important task in biological and...

  • Review
  • Open Access
61 Citations
7,650 Views
29 Pages

4 November 2020

Printed electrochemical biosensors have recently gained increasing relevance in fields ranging from basic research to home-based point-of-care. Thus, they represent a unique opportunity to enable low-cost, fast, non-invasive and/or continuous monitor...

  • Review
  • Open Access
36 Citations
8,200 Views
34 Pages

Modular and Integrated Systems for Nanoparticle and Microparticle Synthesis—A Review

  • Hongda Lu,
  • Shi-Yang Tang,
  • Guolin Yun,
  • Haiyue Li,
  • Yuxin Zhang,
  • Ruirui Qiao and
  • Weihua Li

3 November 2020

Nanoparticles (NPs) and microparticles (MPs) have been widely used in different areas of research such as materials science, energy, and biotechnology. On-demand synthesis of NPs and MPs with desired chemical and physical properties is essential for...

  • Article
  • Open Access
12 Citations
5,892 Views
16 Pages

31 October 2020

Hepatitis B is a globally prevalent viral infectious disease caused by the hepatitis B virus (HBV). In this study, an immunochromatographic assay (ICA) for the rapid detection of hepatitis B preS2 antigen (preS2Ag) was established. The magnetic nanop...

  • Review
  • Open Access
43 Citations
7,385 Views
41 Pages

Carbon-Based Quantum Dots for Electrochemical Detection of Monoamine Neurotransmitters—Review

  • Saheed E. Elugoke,
  • Abolanle S. Adekunle,
  • Omolola E. Fayemi,
  • Bhekie B. Mamba,
  • El-Sayed M. Sherif and
  • Eno E. Ebenso

31 October 2020

Imbalance in the levels of monoamine neurotransmitters have manifested in severe health issues. Electrochemical sensors have been designed for their determination, with good sensitivity recorded. Carbon-based quantum dots have proven to be an importa...

  • Article
  • Open Access
43 Citations
6,203 Views
13 Pages

31 October 2020

In this paper, a nanobiosensor with surface-enhanced Raman scattering (SERS) capability is introduced for highly sensitive miRNA detection in colorectal cancer. This sensor was designed and fabricated by employing a nanoshielding mechanism from nanop...

  • Brief Report
  • Open Access
7 Citations
6,644 Views
8 Pages

High Sensitivity Protein Gel Electrophoresis Label Compatible with Mass-Spectrometry

  • Joshua A. Welsh,
  • Lisa M. Jenkins,
  • Julia Kepley,
  • Gaelyn C. Lyons,
  • David M. Moore,
  • Tim Traynor,
  • Jay A. Berzofsky and
  • Jennifer C. Jones

31 October 2020

Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) is a widely utilized technique for macromolecule and protein analysis. While multiple methods exist to visualize the separated protein bands on gels, one of most popular methods of...

  • Article
  • Open Access
23 Citations
5,276 Views
18 Pages

31 October 2020

Breast cancer is the most common cancer in women. Early diagnosis improves outcome and survival, which is the cornerstone of breast cancer treatment. Thermography has been utilized as a complementary diagnostic technique in breast cancer detection. A...

  • Review
  • Open Access
109 Citations
18,771 Views
16 Pages

30 October 2020

The development of various biosensors has revolutionized the healthcare industry by providing rapid and reliable detection capability. Printed circuit board (PCB) technology has a well-established industry widely available around the world. In additi...

  • Article
  • Open Access
9 Citations
4,152 Views
11 Pages

Microelectrochemical Smart Needle for Real Time Minimally Invasive Oximetry

  • Daniela Vieira,
  • Francis McEachern,
  • Romina Filippelli,
  • Evan Dimentberg,
  • Edward J Harvey and
  • Geraldine Merle

29 October 2020

A variety of brain disorders such as neural injury, brain dysfunction, vascular malformation, and neurodegenerative diseases are associated with abnormal levels of oxygen. Current methods to directly monitor tissue oxygenation in the brain are expens...

  • Article
  • Open Access
7 Citations
3,809 Views
11 Pages

Instrument-Free Protein Microarray Fabrication for Accurate Affinity Measurements

  • Iris Celebi,
  • Matthew T. Geib,
  • Elisa Chiodi,
  • Nese Lortlar Ünlü,
  • Fulya Ekiz Kanik and
  • Selim Ünlü

29 October 2020

Protein microarrays have gained popularity as an attractive tool for various fields, including drug and biomarker development, and diagnostics. Thus, multiplexed binding affinity measurements in microarray format has become crucial. The preparation o...

  • Article
  • Open Access
18 Citations
4,737 Views
12 Pages

Developing a Low-Cost, Simple-to-Use Electrochemical Sensor for the Detection of Circulating Tumour DNA in Human Fluids

  • Bukola Attoye,
  • Chantevy Pou,
  • Ewen Blair,
  • Christopher Rinaldi,
  • Fiona Thomson,
  • Matthew J. Baker and
  • Damion K. Corrigan

28 October 2020

It is well-known that two major issues, preventing improved outcomes from cancer are late diagnosis and the evolution of drug resistance during chemotherapy, therefore technologies that address these issues can have a transformative effect on healthc...

  • Review
  • Open Access
16 Citations
5,389 Views
19 Pages

Biosensors for Detecting Lymphocytes and Immunoglobulins

  • Pietro Salvo,
  • Federico M. Vivaldi,
  • Andrea Bonini,
  • Denise Biagini,
  • Francesca G. Bellagambi,
  • Filippo M. Miliani,
  • Fabio Di Francesco and
  • Tommaso Lomonaco

27 October 2020

Lymphocytes (B, T and natural killer cells) and immunoglobulins are essential for the adaptive immune response against external pathogens. Flow cytometry and enzyme-linked immunosorbent (ELISA) kits are the gold standards to detect immunoglobulins, B...

  • Article
  • Open Access
7 Citations
3,688 Views
15 Pages

Fast Deoxynivalenol Determination in Cereals Using a White Light Reflectance Spectroscopy Immunosensor

  • Vasileios Anastasiadis,
  • Ioannis Raptis,
  • Anastasios Economou,
  • Sotirios E. Kakabakos and
  • Panagiota S. Petrou

25 October 2020

Deoxynivalenol (DON) is a mycotoxin produced by certain Fusarium species and found in a high percentage of wheat and maize grains cultured worldwide. Although not so toxic as other mycotoxins, it exhibits both chronic and acute toxicity, and therefor...

  • Article
  • Open Access
20 Citations
7,341 Views
12 Pages

Development of a Rapid, Antimicrobial Susceptibility Test for E. coli Based on Low-Cost, Screen-Printed Electrodes

  • Stuart Hannah,
  • Alexandra Dobrea,
  • Perrine Lasserre,
  • Ewen O. Blair,
  • David Alcorn,
  • Paul A. Hoskisson and
  • Damion K. Corrigan

23 October 2020

Antibiotic resistance has been cited by the World Health Organisation (WHO) as one of the greatest threats to public health. Mitigating the spread of antibiotic resistance requires a multipronged approach with possible interventions including faster...

  • Review
  • Open Access
122 Citations
11,079 Views
34 Pages

Progress of Advanced Nanomaterials in the Non-Enzymatic Electrochemical Sensing of Glucose and H2O2

  • Dayakar Thatikayala,
  • Deepalekshmi Ponnamma,
  • Kishor Kumar Sadasivuni,
  • John-John Cabibihan,
  • Abdulaziz Khalid Al-Ali,
  • Rayaz A. Malik and
  • Booki Min

22 October 2020

Non-enzymatic sensing has been in the research limelight, and most sensors based on nanomaterials are designed to detect single analytes. The simultaneous detection of analytes that together exist in biological organisms necessitates the development...

  • Article
  • Open Access
40 Citations
8,041 Views
14 Pages

Biocompatibility of Blank, Post-Processed and Coated 3D Printed Resin Structures with Electrogenic Cells

  • Cacie Hart,
  • Charles M. Didier,
  • Frank Sommerhage and
  • Swaminathan Rajaraman

22 October 2020

The widespread adaptation of 3D printing in the microfluidic, bioelectronic, and Bio-MEMS communities has been stifled by the lack of investigation into the biocompatibility of commercially available printer resins. By introducing an in-depth post-pr...

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Biosensors - ISSN 2079-6374