Table of Contents
J. Funct. Biomater., Volume 9, Issue 3 (September 2018)
- Issues are regarded as officially published after their release is announced to the table of contents alert mailing list.
- You may sign up for e-mail alerts to receive table of contents of newly released issues.
- PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.
Cover Story (view full-size image) Fibrin is a promising delivery vehicle to introduce cells into the intervertebral disc (IVD) to [...] Read more. Fibrin is a promising delivery vehicle to introduce cells into the intervertebral disc (IVD) to regenerate damaged tissue for low back pain. However, it lacks key extracellular matrix (ECM) components normally found in native nucleus pulposus (NP) tissue. The overall aim of this work was to create a fibrin-based hydrogel by incorporating collagen (Col) and Hyaluronan (HA) into the matrix to enhance an NP-like matrix accumulation of cells. Results showed that the incorporation of HA promoted sGAG accumulation and tended to suppress collagen formation at higher concentrations. This work suggests that the incorporation of key ECM components can enhance the bioactivity of fibrin-based hydrogels. View this paper.