Table of Contents
J. Funct. Biomater., Volume 9, Issue 3 (September 2018) – 14 articles
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Cover Story (view full-size image) Fibrin is a promising delivery vehicle to introduce cells into the intervertebral disc (IVD) to [...] Read more. Fibrin is a promising delivery vehicle to introduce cells into the intervertebral disc (IVD) to regenerate damaged tissue for low back pain. However, it lacks key extracellular matrix (ECM) components normally found in native nucleus pulposus (NP) tissue. The overall aim of this work was to create a fibrin-based hydrogel by incorporating collagen (Col) and Hyaluronan (HA) into the matrix to enhance an NP-like matrix accumulation of cells. Results showed that the incorporation of HA promoted sGAG accumulation and tended to suppress collagen formation at higher concentrations. This work suggests that the incorporation of key ECM components can enhance the bioactivity of fibrin-based hydrogels. View this paper.