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Journal of Functional Biomaterials, Volume 9, Issue 3

September 2018 - 14 articles

Cover Story: Fibrin is a promising delivery vehicle to introduce cells into the intervertebral disc (IVD) to regenerate damaged tissue for low back pain. However, it lacks key extracellular matrix (ECM) components normally found in native nucleus pulposus (NP) tissue. The overall aim of this work was to create a fibrin-based hydrogel by incorporating collagen (Col) and Hyaluronan (HA) into the matrix to enhance an NP-like matrix accumulation of cells. Results showed that the incorporation of HA promoted sGAG accumulation and tended to suppress collagen formation at higher concentrations. This work suggests that the incorporation of key ECM components can enhance the bioactivity of fibrin-based hydrogels. View this paper.
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Articles (14)

  • Article
  • Open Access
22 Citations
8,526 Views
13 Pages

Specialized Living Wound Dressing Based on the Self-Assembly Approach of Tissue Engineering

  • Laurence Cantin-Warren,
  • Rina Guignard,
  • Sergio Cortez Ghio,
  • Danielle Larouche,
  • François A. Auger and
  • Lucie Germain

There is a high incidence of failure and recurrence for chronic skin wounds following conventional therapies. To promote healing, the use of skin substitutes containing living cells as wound dressings has been proposed. The aim of this study was to p...

  • Article
  • Open Access
23 Citations
6,995 Views
13 Pages

Silymarin-loaded mucoadhesive microbeads of Chitosan-MMT were developed using the ionotropic gelation technique. Characterization of the microbeads was performed by DSC, XRD, SEM, and FTIR techniques. In vitro mucoadhesion and drug release studies; g...

  • Article
  • Open Access
10 Citations
6,354 Views
12 Pages

Fabrication and Multiscale Structural Properties of Interconnected Porous Biomaterial for Tissue Engineering by Freeze Isostatic Pressure (FIP)

  • Mythili Prakasam,
  • Ali Chirazi,
  • Grzegorz Pyka,
  • Anna Prokhodtseva,
  • Daniel Lichau and
  • Alain Largeteau

Biomaterial for tissue engineering is a topic of huge progress with a recent surge in fabrication and characterization advances. Biomaterials for tissue engineering applications or as scaffolds depend on various parameters such as fabrication technol...

  • Review
  • Open Access
52 Citations
8,820 Views
31 Pages

Tailoring the Interface of Biomaterials to Design Effective Scaffolds

  • Ludovica Parisi,
  • Andrea Toffoli,
  • Giulia Ghiacci and
  • Guido M. Macaluso

Tissue engineering (TE) is a multidisciplinary science, which including principles from material science, biology and medicine aims to develop biological substitutes to restore damaged tissues and organs. A major challenge in TE is the choice of suit...

  • Article
  • Open Access
30 Citations
6,785 Views
11 Pages

Experimental and Theoretical Studies on the Adsorption Mechanisms of Uranium (VI) Ions on Chitosan

  • Kenji Mishima,
  • Xiaoyu Du,
  • Naoto Miyamoto,
  • Naoki Kano and
  • Hiroshi Imaizumi

An experiment on the adsorption of uranium (VI) by chitosan was conducted to investigate the efficiency of chitosan as an adsorbent for U(VI). The adsorption potential of U(VI) by chitosan was investigated with ICP-MS by varying the experimental cond...

  • Article
  • Open Access
16 Citations
7,187 Views
11 Pages

Anorganic bovine bone mineral matrix (ABBMM) has been reported to have osteoconductive properties and no inflammatory or adverse responses when used as grafting material in sinus augmentation procedures. However, controversy remains in regard to degr...

  • Article
  • Open Access
6 Citations
6,746 Views
21 Pages

The structural role of Germanium (Ge), when substituting for Zinc (Zn) up to 8 mol % in the 0.48SiO2–0.12CaO–0.36ZnO–0.04MgO glass series, was investigated with respect to both the glass chemistry and also the properties of glass po...

  • Feature Paper
  • Article
  • Open Access
20 Citations
7,983 Views
18 Pages

Tissue Engineering Scaffolds Fabricated in Dissolvable 3D-Printed Molds for Patient-Specific Craniofacial Bone Regeneration

  • Angela Alarcon De la Lastra,
  • Katherine R. Hixon,
  • Lavanya Aryan,
  • Amanda N. Banks,
  • Alexander Y. Lin,
  • Andrew F. Hall and
  • Scott A. Sell

The current gold standard treatment for oral clefts is autologous bone grafting. This treatment, however, presents another wound site for the patient, greater discomfort, and pediatric patients have less bone mass for bone grafting. A potential alter...

  • Article
  • Open Access
10 Citations
9,546 Views
13 Pages

Interconnected PolymerS TeChnology (IPSTiC): An Effective Approach for the Modulation of 5α-Reductase Activity in Hair Loss Conditions

  • Ortensia Ilaria Parisi,
  • Luca Scrivano,
  • Fabio Amone,
  • Rocco Malivindi,
  • Mariarosa Ruffo,
  • Anna Francesca Vattimo,
  • Vincenzo Pezzi and
  • Francesco Puoci

Hair loss represents a condition that adversely affects the social life of patients. The most common cause is androgenetic alopecia (AGA), which is a genetically determined progressive hair-loss condition involving 5α-reductase. In this study,...

  • Article
  • Open Access
65 Citations
11,154 Views
17 Pages

A Decellularized Porcine Xenograft-Derived Bone Scaffold for Clinical Use as a Bone Graft Substitute: A Critical Evaluation of Processing and Structure

  • Daniel N. Bracey,
  • Thorsten M. Seyler,
  • Alexander H. Jinnah,
  • Mark O. Lively,
  • Jeffrey S. Willey,
  • Thomas L. Smith,
  • Mark E. Van Dyke and
  • Patrick W. Whitlock

Background: Bone grafts are used in approximately one half of all musculoskeletal surgeries. Autograft bone is the historic gold standard but is limited in supply and its harvest imparts significant morbidity to the patient. Alternative sources of bo...

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J. Funct. Biomater. - ISSN 2079-4983Creative Common CC BY license