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J. Funct. Biomater. 2018, 9(3), 52;

Formulation and Evaluation of Silymarin-Loaded Chitosan-Montmorilloite Microbeads for the Potential Treatment of Gastric Ulcers

Department of Pharmaceutics, Chitkara College of Pharmacy, Chitkara University, Patiala 140401, India
University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160101, India
Author to whom correspondence should be addressed.
Received: 30 July 2018 / Revised: 28 August 2018 / Accepted: 4 September 2018 / Published: 10 September 2018
(This article belongs to the Special Issue Clay-Based Biomaterials: From Synthesis to Applications)
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Silymarin-loaded mucoadhesive microbeads of Chitosan-MMT were developed using the ionotropic gelation technique. Characterization of the microbeads was performed by DSC, XRD, SEM, and FTIR techniques. In vitro mucoadhesion and drug release studies; gastroprotective studies including the measurement of ulcerative index; the determination of gastric wall mucus; and the determination of percentage protection, biochemical, and histopathological studies were also performed. Microbeads batches were evaluated for particle size (120–140 µm), actual drug content, (49.36–58.18%) and entrapment efficiency (72.52–92.39%).Biochemical estimation of myeloperoxidase was found to be 0.10–0.75 µmoles/g/tissue. Significant reduction in the ulcerative index showed the gastroprotective effect of the formulation. Silymarin-loaded beads of Chitosan-MMT were found to exhibit good mucoadhesion and efficient release of the drug, and were found to be a promising drug carrier system for the treatment of gastric ulcers. View Full-Text
Keywords: Microbeads; silymarin; chitosan; montmorillonite; gastric ulcers Microbeads; silymarin; chitosan; montmorillonite; gastric ulcers

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Sharma, A.; Puri, V.; Kakkar, V.; Singh, I. Formulation and Evaluation of Silymarin-Loaded Chitosan-Montmorilloite Microbeads for the Potential Treatment of Gastric Ulcers. J. Funct. Biomater. 2018, 9, 52.

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