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J. Funct. Biomater. 2018, 9(3), 44; https://doi.org/10.3390/jfb9030044

Interconnected PolymerS TeChnology (IPSTiC): An Effective Approach for the Modulation of 5α-Reductase Activity in Hair Loss Conditions

1
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende (CS), Italy
2
Macrofarm s.r.l., c/o Department of Pharmacy, Health and Nutrition Sciences, University of Calabria, 87036 Rende (CS), Italy
*
Author to whom correspondence should be addressed.
Received: 16 April 2018 / Revised: 3 July 2018 / Accepted: 10 July 2018 / Published: 12 July 2018
(This article belongs to the Special Issue Functional Materials for Healthcare)
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Abstract

Hair loss represents a condition that adversely affects the social life of patients. The most common cause is androgenetic alopecia (AGA), which is a genetically determined progressive hair-loss condition involving 5α-reductase. In this study, a novel anti-baldness agent based on Interconnected PolymerS TeChnology (IPSTiC), which is an effective strategy for the delivery of bioactive molecules, was developed. This product (IPSTiC patch hair) is based on a polymeric blend consisting of high molecular weight hyaluronic acid and soybean proteins and is able to improve efficacy and stability of bioactive ingredients such as Origanum vulgare leaf extract, Camellia Sinensis leaf extract, and Capsicum Annuum fruit extract. The efficacy of the developed anti-baldness agent was investigated by performing several tests including NO radical and 5α-reductase inhibition assays, stability studies under different conditions, and in vitro diffusion studies using Franz cells. The biocompatibility of IPSTiC patch hair was also evaluated by in vitro analysis of the pro-sensitising potential and EPISKIN model. The obtained results confirmed both the efficacy and safety of IPSTiC patch hair supporting the potential use of this product in the topical treatment of AGA. View Full-Text
Keywords: hair loss; androgenetic alopecia (AGA); 5α-reductase; polymeric blend; hyaluronic acid; soybean proteins; Origanum vulgare leaf extract; Camellia Sinensis leaf extract; Capsicum Annuum fruit extract; EPISKIN model hair loss; androgenetic alopecia (AGA); 5α-reductase; polymeric blend; hyaluronic acid; soybean proteins; Origanum vulgare leaf extract; Camellia Sinensis leaf extract; Capsicum Annuum fruit extract; EPISKIN model
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Parisi, O.I.; Scrivano, L.; Amone, F.; Malivindi, R.; Ruffo, M.; Vattimo, A.F.; Pezzi, V.; Puoci, F. Interconnected PolymerS TeChnology (IPSTiC): An Effective Approach for the Modulation of 5α-Reductase Activity in Hair Loss Conditions. J. Funct. Biomater. 2018, 9, 44.

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