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Journal of Functional Biomaterials, Volume 16, Issue 8

August 2025 - 36 articles

Cover Story: Simulated microgravity, achieved through rotating wall vessel bioreactors, provides a unique 3D dynamic culture environment that enhances tissue engineering by mimicking space-like conditions. In bone tissue research, 3D-printed trabecular scaffolds cultured under such conditions show a specific cell response. The absence of sedimentation and the continuous rotation allow uniform cell distribution, improve the delivery of nutrients and oxygen, and facilitate the removal of metabolic waste. Beyond bone, simulated microgravity offers a powerful platform for advancing all tissue engineering fields, enabling more physiologically relevant models and accelerating biomedical innovation to support space medicine. View this paper
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Articles (36)

  • Article
  • Open Access
1,244 Views
14 Pages

Photothermally Responsive Biomimetic Composite Scaffolds Based on Polydopamine-Functionalized Nanoparticles/Polyurethane for Bone Repair

  • Ruqing Bai,
  • Jiaqi Chen,
  • Ting Zhang,
  • Tao Chen,
  • Xiaoying Liu,
  • Weihu Yang,
  • Tuck-Whye Wong,
  • Jianwei Zhang and
  • Li Wang

In this study, a shape-changeable 3D scaffold with photothermal effects was developed to address the clinical challenges of complex bone defects. The multifunctional construct was fabricated via in situ polymerization combined with a gas foaming tech...

  • Systematic Review
  • Open Access
1 Citations
3,658 Views
36 Pages

Efficacy of Endodontic Files in Root Canal Retreatment: A Systematic Review of In Vitro Studies

  • Anna Soler-Doria,
  • José Luis Sanz,
  • Marcello Maddalone and
  • Leopoldo Forner

The success rate of root canal treatment is high, but it can fail. In these cases, orthograde root canal retreatment is often the treatment of choice, for which numerous biomaterials are available on the market, including endodontic files. This syste...

  • Article
  • Open Access
2,170 Views
15 Pages

Injectable Thermosensitive Hydrogel Containing Bakuchiol Reduces Periodontal Inflammation and Alveolar Bone Loss in a Rat Model

  • Seong-Jin Shin,
  • Gyu-Yeon Shim,
  • Seong-Hee Moon,
  • Yu-Jin Kim,
  • Hyun-Jin Kim,
  • Seunghan Oh,
  • Jung-Hwan Lee and
  • Ji-Myung Bae

This study aimed to develop and evaluate a bakuchiol-loaded thermosensitive hydrogel (BTH) as a novel local drug delivery system for the management of periodontitis. Bakuchiol, a natural phenolic compound extracted from Psoralea corylifolia, was inco...

  • Article
  • Open Access
1 Citations
2,072 Views
19 Pages

Analysis of Insertion Torque of Orthodontic Mini-Implants Depending on the System and the Morphological Substrate

  • Tamara Rahela Ioana,
  • Filip George Boeru,
  • Ioana Mitruț,
  • Anne-Marie Rauten,
  • Mahmoud Elsaafin,
  • Mihaela Ionescu,
  • Ionela Elisabeta Staicu and
  • Horia Octavian Manolea

Orthodontic mini-implants are well-known anchorage devices and stand out as a particularly effective tool for ensuring maximum anchorage without relying on patient compliance. Therefore, it is necessary to understand what levels of torque strains rem...

  • Article
  • Open Access
2 Citations
1,166 Views
14 Pages

The mechanical behavior of dental composites depends on the sample size and stress configuration. This makes it difficult to extrapolate laboratory data to clinical restorations with significant variations in size and geometry. Intrinsic parameters,...

  • Article
  • Open Access
2,418 Views
15 Pages

Shear Bond Strength of Self-Adhesive and Self-Etching Resin Cements to Dentin for Indirect Restorations

  • Janet Kirilova,
  • Georgi Veselinov Iliev,
  • Sevda Yantcheva,
  • Elitsa Deliverska and
  • Viktoria Petrova

This study assessed and compared the shear bond strength of self-adhesive and self-etching resin cements for indirect aesthetic restorations to dentin. Four different materials, lithium disilicate ceramics, zirconia ceramics, polymethyl methacrylate...

  • Article
  • Open Access
1 Citations
1,632 Views
13 Pages

Promoting Surface Energy and Osteoblast Viability on Zirconia Implant Abutments Through Glass–Ceramic Spray Deposition Technology

  • Wen-Chieh Hsu,
  • Tao-Yu Cha,
  • Yu-Chin Yao,
  • Chien-Ming Kang,
  • Sheng-Han Wu,
  • Yuichi Mine,
  • Chien-Fu Tseng,
  • I-Ta Lee,
  • Dan-Jae Lin and
  • Tzu-Yu Peng

Zirconia is used widely for high-precision custom abutments; however, stress concentration can compromise osseointegration. Although glass–ceramic spray deposition (GCSD) can enhance the surface properties of zirconia, its biological effects re...

  • Article
  • Open Access
1,109 Views
18 Pages

Pressure therapy combined with silicone has a significant effect on scar hyperplasia, but limitations such as long-term wearing of compression garments (CGs) can easily cause bacterial infection, cleanliness, and lifespan problems of CGs caused by th...

  • Article
  • Open Access
1 Citations
1,871 Views
12 Pages

Evaluation of Hydroxyapatite–β-Tricalcium Phosphate Collagen Composites for Socket Preservation in a Canine Model

  • Dong Woo Kim,
  • Donghyun Lee,
  • Jaeyoung Ryu,
  • Min-Suk Kook,
  • Hong-Ju Park and
  • Seunggon Jung

This study aimed to compare the performance of three hydroxyapatite–β-tricalcium phosphate (HA–β-TCP) collagen composite grafts in a canine model for extraction socket preservation. Eight mongrel dogs underwent atraumatic bilate...

  • Review
  • Open Access
2,059 Views
32 Pages

Polyphosphazene-Based Nanotherapeutics

  • Sara Gutierrez-Gutierrez,
  • Rocio Mellid-Carballal,
  • Noemi Csaba and
  • Marcos Garcia-Fuentes

Poly(organo)phosphazenes (PPZs) are increasingly recognized as versatile biomaterials for drug delivery applications in nanomedicine. Their unique hybrid structure—featuring an inorganic backbone and highly tunable organic side chains—con...

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J. Funct. Biomater. - ISSN 2079-4983