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Journal of Clinical Medicine, Volume 4, Issue 12

2015 December - 7 articles

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Articles (7)

  • Feature Paper
  • Review
  • Open Access
47 Citations
7,655 Views
14 Pages

Epithelial-to-Mesenchymal Transition and Cancer Invasiveness: What Can We Learn from Cholangiocarcinoma?

  • Simone Brivio,
  • Massimiliano Cadamuro,
  • Luca Fabris and
  • Mario Strazzabosco

19 December 2015

In addition to its well-established role in embryo development, epithelial-to-mesenchymal transition (EMT) has been proposed as a general mechanism favoring tumor metastatization in several epithelial malignancies. Herein, we review the topic of EMT...

  • Article
  • Open Access
132 Citations
12,682 Views
16 Pages

Detection of Exosomal miRNAs in the Plasma of Melanoma Patients

  • Susan R. Pfeffer,
  • Kenneth F. Grossmann,
  • Pamela B. Cassidy,
  • Chuan He Yang,
  • Meiyun Fan,
  • Levy Kopelovich,
  • Sancy A. Leachman and
  • Lawrence M. Pfeffer

17 December 2015

MicroRNAs (miRNAs) are a class of 22–25 nucleotide RNAs that control gene expression at the post-transcriptional level. MiRNAs have potential as cancer biomarkers. Melanoma is a highly aggressive form of skin cancer accounting for almost 4% of cancer...

  • Review
  • Open Access
99 Citations
13,757 Views
13 Pages

Pork as a Source of Omega-3 (n-3) Fatty Acids

  • Michael E.R. Dugan,
  • Payam Vahmani,
  • Tyler D. Turner,
  • Cletos Mapiye,
  • Manuel Juárez,
  • Nuria Prieto,
  • Angela D. Beaulieu,
  • Ruurd T. Zijlstra,
  • John F. Patience and
  • Jennifer L. Aalhus

16 December 2015

Pork is the most widely eaten meat in the world, but typical feeding practices give it a high omega-6 (n-6) to omega-3 (n-3) fatty acid ratio and make it a poor source of n-3 fatty acids. Feeding pigs n-3 fatty acids can increase their contents in po...

  • Article
  • Open Access
16 Citations
6,791 Views
9 Pages

4 December 2015

MicroRNAs are small (~22 nt), noncoding RNA molecules that have critical cellular functions in proliferation, differentiation, angiogenesis and apoptosis. miRNA expression profiling has been used to create signatures of solid tumors and, in many case...

  • Review
  • Open Access
53 Citations
12,184 Views
17 Pages

Claudin 1 in Breast Cancer: New Insights

  • Bowen Zhou,
  • Amanda Moodie,
  • Anne A. A. Blanchard,
  • Etienne Leygue and
  • Yvonne Myal

27 November 2015

Claudin 1 is a small transmembrane protein responsible for maintaining the barrier function that exists between epithelial cells. A tight junction protein that regulates the paracellular transport of small ions across adjacent cells, claudin 1 mainta...

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J. Clin. Med. - ISSN 2077-0383