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Journal of Clinical Medicine, Volume 4, Issue 12

2015 December - 7 articles

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Articles (7)

  • Feature Paper
  • Review
  • Open Access
48 Citations
8,103 Views
14 Pages

Epithelial-to-Mesenchymal Transition and Cancer Invasiveness: What Can We Learn from Cholangiocarcinoma?

  • Simone Brivio,
  • Massimiliano Cadamuro,
  • Luca Fabris and
  • Mario Strazzabosco

19 December 2015

In addition to its well-established role in embryo development, epithelial-to-mesenchymal transition (EMT) has been proposed as a general mechanism favoring tumor metastatization in several epithelial malignancies. Herein, we review the topic of EMT...

(This article belongs to the Special Issue Epithelial-Mesenchymal Transition)
  • Article
  • Open Access
134 Citations
12,954 Views
16 Pages

Detection of Exosomal miRNAs in the Plasma of Melanoma Patients

  • Susan R. Pfeffer,
  • Kenneth F. Grossmann,
  • Pamela B. Cassidy,
  • Chuan He Yang,
  • Meiyun Fan,
  • Levy Kopelovich,
  • Sancy A. Leachman and
  • Lawrence M. Pfeffer

17 December 2015

MicroRNAs (miRNAs) are a class of 22–25 nucleotide RNAs that control gene expression at the post-transcriptional level. MiRNAs have potential as cancer biomarkers. Melanoma is a highly aggressive form of skin cancer accounting for almost 4% of cancer...

(This article belongs to the Special Issue MicroRNAs: Novel Biomarkers and Therapeutic Targets for Human Cancers)
  • Review
  • Open Access
102 Citations
14,693 Views
13 Pages

Pork as a Source of Omega-3 (n-3) Fatty Acids

  • Michael E.R. Dugan,
  • Payam Vahmani,
  • Tyler D. Turner,
  • Cletos Mapiye,
  • Manuel Juárez,
  • Nuria Prieto,
  • Angela D. Beaulieu,
  • Ruurd T. Zijlstra,
  • John F. Patience and
  • Jennifer L. Aalhus

16 December 2015

Pork is the most widely eaten meat in the world, but typical feeding practices give it a high omega-6 (n-6) to omega-3 (n-3) fatty acid ratio and make it a poor source of n-3 fatty acids. Feeding pigs n-3 fatty acids can increase their contents in po...

(This article belongs to the Special Issue Omega-3 Fatty Acids in Health and Disease)
  • Review
  • Open Access
78 Citations
18,272 Views
12 Pages

4 December 2015

Nonalcoholic fatty liver disease (NAFLD) has become the most common liver disorder. Strongly linked to obesity and diabetes, NAFLD has the characteristics of complex diseases with substantial heterogeneity. Accordingly, our ability to predict the ris...

(This article belongs to the Special Issue MicroRNAs: Novel Biomarkers for Liver Diseases)
  • Article
  • Open Access
18 Citations
7,258 Views
9 Pages

4 December 2015

MicroRNAs are small (~22 nt), noncoding RNA molecules that have critical cellular functions in proliferation, differentiation, angiogenesis and apoptosis. miRNA expression profiling has been used to create signatures of solid tumors and, in many case...

(This article belongs to the Special Issue MicroRNAs: Novel Biomarkers for Liver Diseases)
  • Review
  • Open Access
55 Citations
12,929 Views
17 Pages

Claudin 1 in Breast Cancer: New Insights

  • Bowen Zhou,
  • Amanda Moodie,
  • Anne A. A. Blanchard,
  • Etienne Leygue and
  • Yvonne Myal

27 November 2015

Claudin 1 is a small transmembrane protein responsible for maintaining the barrier function that exists between epithelial cells. A tight junction protein that regulates the paracellular transport of small ions across adjacent cells, claudin 1 mainta...

(This article belongs to the Special Issue Epithelial-Mesenchymal Transition)
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J. Clin. Med. - ISSN 2077-0383