Claudin 1 in Breast Cancer: New Insights
AbstractClaudin 1 is a small transmembrane protein responsible for maintaining the barrier function that exists between epithelial cells. A tight junction protein that regulates the paracellular transport of small ions across adjacent cells, claudin 1 maintains cellular polarity and plays a major role in cell-cell communication and epithelial cell homeostasis. Long considered to be a putative tumor suppressor in human breast cancer, new studies suggest a role much more complex. While most invasive breast cancers exhibit a down regulation or absence of claudin 1, some aggressive subtypes that exhibit high claudin 1 levels have now been described. Furthermore, a causal role for claudin 1 in breast cancer progression has recently been demonstrated in some breast cancer cell lines. In this review we highlight new insights into the role of claudin 1 in breast cancer, including its involvement in collective migration and epithelial mesenchymal transition (EMT). View Full-Text
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Zhou, B.; Moodie, A.; Blanchard, A.A.A.; Leygue, E.; Myal, Y. Claudin 1 in Breast Cancer: New Insights. J. Clin. Med. 2015, 4, 1960-1976.
Zhou B, Moodie A, Blanchard AAA, Leygue E, Myal Y. Claudin 1 in Breast Cancer: New Insights. Journal of Clinical Medicine. 2015; 4(12):1960-1976.Chicago/Turabian Style
Zhou, Bowen; Moodie, Amanda; Blanchard, Anne A.A.; Leygue, Etienne; Myal, Yvonne. 2015. "Claudin 1 in Breast Cancer: New Insights." J. Clin. Med. 4, no. 12: 1960-1976.