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Journal of Clinical Medicine, Volume 11, Issue 6

March-2 2022 - 284 articles

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Cover Story: Percutaneous left atrial appendage closure using the WATCHMAN system to prevent thrombosis with minimizing anti-coagulant in patients with non-valvular atrial fibrillation has recently been introduced. We demonstrated that a new-generation WATCHMAN FLX can be as safe and effective as a conventional WATCHMAN 2.5 during a short-term observational period following the procedure. Further longer-term observational studies are warranted to investigate the clinical advantage of the WATCHMAN FLX system. View this paper

Articles (284)

  • Article
  • Open Access
4 Citations
2,782 Views
11 Pages

Over-Mutated Mitochondrial, Lysosomal and TFEB-Regulated Genes in Parkinson’s Disease

  • Eulàlia Segur-Bailach,
  • Olatz Ugarteburu,
  • Frederic Tort,
  • Laura Texido,
  • Celia Painous,
  • Yaroslau Compta,
  • Maria José Martí,
  • Antonia Ribes and
  • Laura Gort

21 March 2022

The association between Parkinson’s disease (PD) and mutations in genes involved in lysosomal and mitochondrial function has been previously reported. However, little is known about the involvement of other genes or cellular mechanisms. We aim...

  • Article
  • Open Access
2 Citations
2,326 Views
13 Pages

Prescription of Blood Lymphocyte Immunophenotyping in the Diagnosis of Lymphoid Neoplasms in Older Adults

  • Jérémie Vovelle,
  • Céline Row,
  • Fabrice Larosa,
  • Julien Guy,
  • Anca-Maria Mihai,
  • Marc Maynadié,
  • Jérémy Barben and
  • Patrick Manckoundia

21 March 2022

Lymphoid neoplasms are a heterogeneous group of lymphoid neoplastic diseases with multiple presentations, and varying prognoses. They are especially frequent in older patients (OPs) and the atypism of this frail elderly population can make the diagno...

  • Perspective
  • Open Access
47 Citations
14,364 Views
19 Pages

21 March 2022

Interstitial lung diseases (ILD) or diffuse parenchymal lung diseases (DPLD) comprise a large number of disorders. Disease definition and classification allow advanced and personalized judgements on clinical disease, risks for genetic or environmenta...

  • Article
  • Open Access
8 Citations
3,629 Views
14 Pages

Attention to Speech and Music in Young Children with Bilateral Cochlear Implants: A Pupillometry Study

  • Amanda Saksida,
  • Sara Ghiselli,
  • Lorenzo Picinali,
  • Sara Pintonello,
  • Saba Battelino and
  • Eva Orzan

21 March 2022

Early bilateral cochlear implants (CIs) may enhance attention to speech, and reduce cognitive load in noisy environments. However, it is sometimes difficult to measure speech perception and listening effort, especially in very young children. Behavio...

  • Review
  • Open Access
8 Citations
4,259 Views
17 Pages

Respiratory Follow Up of the Premature Neonates—Rationale and Practical Issues

  • Raluca Daniela Bogdan,
  • Roxana Elena Bohiltea and
  • Adrian Ioan Toma

21 March 2022

The aim of the review was to present the state of knowledge about the respiratory pathology in former premature neonates (children that were born preterm—before 37 weeks of gestation—and are examined and evaluated after 40 weeks corrected...

  • Article
  • Open Access
7 Citations
2,650 Views
16 Pages

Impaired Neutralizing Antibody Activity against B.1.617.2 (Delta) after Anti-SARS-CoV-2 Vaccination in Patients Receiving Anti-CD20 Therapy

  • Maximilian Töllner,
  • Claudius Speer,
  • Louise Benning,
  • Marie Bartenschlager,
  • Christian Nusshag,
  • Christian Morath,
  • Martin Zeier,
  • Caner Süsal,
  • Paul Schnitzler and
  • Wilhelm Schmitt
  • + 4 authors

21 March 2022

Background: To characterize humoral response after standard anti-SARS-CoV-2 vaccination in Rituximab-treated patients and to determine the optimal time point after last Rituximab treatment for appropriate immunization. Methods: Sixty-four patients wh...

  • Review
  • Open Access
20 Citations
4,063 Views
15 Pages

The Role of Radiomics in the Era of Immune Checkpoint Inhibitors: A New Protagonist in the Jungle of Response Criteria

  • Angelo Castello,
  • Massimo Castellani,
  • Luigia Florimonte,
  • Luca Urso,
  • Luigi Mansi and
  • Egesta Lopci

21 March 2022

Immune checkpoint inhibitors (ICI) have demonstrated encouraging results in terms of durable clinical benefit and survival in several malignancies. Nevertheless, the search to identify an “ideal” biomarker for predicting response to ICI i...

  • Review
  • Open Access
7 Citations
4,297 Views
14 Pages

Comparative Study by Systematic Review and Meta-Analysis of the Peri-Implant Effect of Two Types of Platforms: Platform-Switching versus Conventional Platforms

  • Alejo Juan-Montesinos,
  • Rubén Agustín-Panadero,
  • Maria Fernanda Solá-Ruiz,
  • Rocío Marco-Pitarch,
  • Jose María Montiel-Company and
  • Carla Fons-Badal

21 March 2022

Objective: The aim of the systematic review and meta-analysis carried out was to evaluate the effects of changing the prosthetic platform on peri-implant tissue after 1 year of prosthetic loading. Material and methods: In November 2020, an electronic...

  • Review
  • Open Access
12 Citations
4,759 Views
28 Pages

Unveiling the Pathogenesis of Adenomyosis through Animal Models

  • Xi Wang,
  • Giuseppe Benagiano,
  • Xishi Liu and
  • Sun-Wei Guo

21 March 2022

Background: Adenomyosis is a common gynecological disorder traditionally viewed as “elusive”. Several excellent review papers have been published fairly recently on its pathogenesis, and several theories have been proposed. However, the f...

  • Article
  • Open Access
8 Citations
2,528 Views
10 Pages

The Multifaceted Presentation of the Multisystem Inflammatory Syndrome in Children: Data from a Cluster Analysis

  • Hafize Emine Sönmez,
  • Şengül Çağlayan,
  • Gülçin Otar Yener,
  • Eviç Zeynep Başar,
  • Kadir Ulu,
  • Mustafa Çakan,
  • Vafa Guliyeva,
  • Esra Bağlan,
  • Kübra Öztürk and
  • Demet Demirkol
  • + 5 authors

21 March 2022

Background: The aim of this study was to evaluate the outcomes of patients with the multisystem inflammatory syndrome in children (MIS-C) according to phenotypes of disease and define the prognostic factors for the severe course. Methods: This cross-...

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