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Journal of Clinical Medicine, Volume 10, Issue 9

May-1 2021 - 244 articles

Cover Story: Mutations of the actin motor protein myosinVb (myo5b) cause congenital enteropathy microvillus inclusion disease (MVID) and have also recently been associated with progressive familial intrahepatic cholestasis (MYO5B-PFIC). Advanced electron microscopy of intestinal biopsies and enteroids from a patient with MYO5B-PFIC revealed all the typical MVID features, particularly subapical clusters of abnormal Rab11-Rab8 compartments harboring proteins essential for brush border assembly and cargo transport (left panels). Similar aberrant clusters of Rab11 vesicles and partial mislocalization of bile duct membrane proteins were identified in hepatocytes from the same patient (right panels)—an interesting coincidence that requires further investigation. View this paper.
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Articles (244)

  • Article
  • Open Access
4 Citations
2,712 Views
17 Pages

Prospective Measures of Adherence by Questionnaire, Low Immunosuppression and Graft Outcome in Kidney Transplantation

  • Mathilde Prezelin-Reydit,
  • Valérie Dubois,
  • Sophie Caillard,
  • Anne Parissiadis,
  • Isabelle Etienne,
  • Françoise Hau,
  • Laetitia Albano,
  • Monique Pourtein,
  • Benoît Barrou and
  • Jean-Luc Taupin
  • + 9 authors

10 May 2021

Background: Non-adherence with immunosuppressant medication (MNA) fosters development of de novo donor-specific antibodies (dnDSA), rejection, and graft failure (GF) in kidney transplant recipients (KTRs). However, there is no simple tool to assess M...

  • Article
  • Open Access
10 Citations
4,085 Views
8 Pages

The Uterocervical Angle Combined with Bishop Score as a Predictor for Successful Induction of Labor in Term Vaginal Delivery

  • Seung-Woo Yang,
  • Seo-Yeon Kim,
  • Han-Sung Hwang,
  • Hee-Sun Kim,
  • In-Sook Sohn and
  • Han-Sung Kwon

10 May 2021

The objective of this study was to determine the value of uterocervical angle (UCA) in predicting successful induction of labor (IOL) in singleton pregnant women compared to the Bishop score and cervical length (CL). A total of 205 normal term, singl...

  • Article
  • Open Access
25 Citations
6,070 Views
12 Pages

10 May 2021

Glioblastoma multiforme (GBM) carries a poor prognosis and usually presents with heterogenous regions of a necrotic core, solid part, peritumoral tissue, and peritumoral edema. Accurate demarcation on magnetic resonance imaging (MRI) between the acti...

  • Article
  • Open Access
7 Citations
4,000 Views
9 Pages

Short Plate with Screw Angle over 20 Degrees Improves the Radiologic Outcome in ACDF: Clinical Study

  • Kathryn-Anne Jimenez,
  • Jihyeon Kim,
  • Jaenam Lee,
  • Hwan-Mo Lee,
  • Seong-Hwan Moon,
  • Kyung-Soo Suk,
  • Hak-Sun Kim and
  • Byung-Ho Lee

10 May 2021

Background: Anterior cervical discectomy and fusion surgery is a common procedure for degenerative cervical spine. This describes allospacer and implant-related outcomes, comparing medium plate–low screw angle and short plate–high screw angle techniq...

  • Article
  • Open Access
1 Citations
2,611 Views
12 Pages

Differences in Somatic Mutation Profiles between Korean Gastric Cancer and Gastric Adenoma Patients

  • Seung Woo Lee,
  • Taekyu Lee,
  • Hae Jung Sul,
  • Ki Cheol Park and
  • Joonhong Park

10 May 2021

Background: We aimed to investigate molecular factors potentially related to the progression of gastric adenoma (GA) to gastric cancer (GC) and compare the mutation characteristics between GC and GA. Methods: We conducted custom gene panel sequencing...

  • Review
  • Open Access
13 Citations
4,760 Views
10 Pages

SGLT2 Inhibitors, What the Emergency Physician Needs to Know: A Narrative Review

  • Henri Lu,
  • Hortense Lu,
  • Christophe Kosinski,
  • Anne Wojtusciszyn,
  • Anne Zanchi,
  • Pierre-Nicolas Carron,
  • Martin Müller,
  • Philippe Meyer,
  • Jehan Martin and
  • Olivier Muller
  • + 1 author

10 May 2021

Canagliflozin, dapagliflozin, empagliflozin, and ertugliflozin belong to a class of antidiabetic treatments referred to as sodium-glucose cotransporter 2 inhibitors (SGLT2 inhibitors, or SGLT2is). SGLT2is are currently indicated in North America and...

  • Article
  • Open Access
2 Citations
3,036 Views
9 Pages

Analysis of Nonunion in Conservatively Managed Anterior Tear Drop Fractures of C2 Vertebra

  • Sung-Kyu Kim,
  • John M. Rhee,
  • Eric T. Park and
  • Hyoung-Yeon Seo

10 May 2021

Many anterior C2 (2nd cervical vertebra) tear drop (TD) fractures can be successfully managed with conservative treatment. However, due to the occurrence of nonunion, large-sized or complex anterior C2 TD fractures undergo surgical treatment. To date...

  • Article
  • Open Access
9 Citations
3,218 Views
9 Pages

Prevalence of Sleep Disordered Breathing in Patients with Primary Mitral Regurgitation Undergoing Mitral Valve Surgery

  • Muhammed Gerçek,
  • Olaf Oldenburg,
  • Mustafa Gerçek,
  • Henrik Fox,
  • Volker Rudolph,
  • Thomas Puehler,
  • Hazem Omran,
  • Lisa Katharina Wolf,
  • Kavous Hakim-Meibodi and
  • Andreas M. Zeiher
  • + 2 authors

10 May 2021

Background: Sleep disordered breathing (SDB) is a frequent comorbidity in cardiac disease patients. Nevertheless, the prevalence and relationship between SDB and severe primary mitral regurgitation (PMR) has not been well investigated to date. Method...

  • Review
  • Open Access
15 Citations
4,935 Views
15 Pages

10 May 2021

Non-alcoholic fatty liver disease is a highly prevalent disease worldwide with a renowned relation to cardiovascular disease and chronic kidney disease. These diseases share a common pathophysiology including insulin resistance, oxidative stress, chr...

  • Article
  • Open Access
16 Citations
4,956 Views
14 Pages

Impact of Kidney Failure on the Severity of COVID-19

  • Dorota Zarębska-Michaluk,
  • Jerzy Jaroszewicz,
  • Magdalena Rogalska,
  • Beata Lorenc,
  • Marta Rorat,
  • Anna Szymanek-Pasternak,
  • Anna Piekarska,
  • Aleksandra Berkan-Kawińska,
  • Katarzyna Sikorska and
  • Magdalena Tudrujek-Zdunek
  • + 12 authors

10 May 2021

Background: Patients with kidney failure are at an increased risk of progression to a severe form of coronavirus disease 2019 (COVID-19) with high mortality. The current analysis was aimed to assess the impact of renal failure on the severity of COVI...

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J. Clin. Med. - ISSN 2077-0383