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The Risk of Osteoporosis and Osteoporotic Fracture Following the Use of Irritable Bowel Syndrome Medical Treatment: An Analysis Using the OMOP CDM Database

1
Department of Family Medicine, Medical Research Institute and Busan Tobacco Control Center, Pusan National University Hospital, Busan 49241, Korea
2
Pusan National University School of Medicine, Yangsan 50612, Korea
3
Clinical Trial Center, Department of Biostatistics, Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Korea
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Department of Family Medicine, National Health Insurance Service Ilsan Hospital, Goyang 10444, Korea
5
Family Medicine Clinic, Obesity, Metabolism and Nutrition Center Pusan National University Yangsan Hospital, Yangsan 50612, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Gabrio Bassotti
J. Clin. Med. 2021, 10(9), 2044; https://doi.org/10.3390/jcm10092044
Received: 26 February 2021 / Revised: 1 May 2021 / Accepted: 5 May 2021 / Published: 10 May 2021
(This article belongs to the Collection Latest Research in Irritable Bowel Syndrome)
Patients with irritable bowel syndrome (IBS) are at increased risk of osteoporosis and osteoporotic fracture. This study investigated whether IBS medication attenuated the rate of osteoporosis and osteoporotic fracture risk. We conducted a retrospective large-scale multicenter study across eight hospital databases encoded in the Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM). The primary outcome was the incidence of osteoporosis, whereas secondary outcomes were osteoporotic fractures. After 1:4 matching, 24,723 IBS patients, 78,318 non-IBS patients, 427,640 non-IBS patients with IBS medication, and 827,954 non-IBS patients without IBS medication were selected. The risk of osteoporosis was significantly increased in the IBS group compared to the non-IBS group (hazard ratio (HR) 1.33; confidence interval (CI) 1.17~1.51). Even in patients who were not diagnosed with IBS, the risk of osteoporosis was significantly increased in those with IBS medication compared to those without (HR 1.77, CI 1.62~1.93). The risk of osteoporotic fracture was significantly increased in the IBS medication group (HR 1.69, CI 1.55~1.84). Patients exposed to IBS treatment even without IBS diagnosis were at increased risk of osteoporosis and osteoporotic fracture. Early diagnosis and treatment of osteoporosis should be considered in patients who have received medication for IBS symptoms. View Full-Text
Keywords: irritable bowel syndrome; osteoporosis; treatment for IBS irritable bowel syndrome; osteoporosis; treatment for IBS
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MDPI and ACS Style

Kim, G.L.; Yi, Y.H.; Hwang, H.R.; Kim, J.; Park, Y.; Kim, Y.J.; Lee, J.G.; Tak, Y.J.; Lee, S.H.; Lee, S.Y.; Cho, Y.H.; Park, E.J.; Lee, Y. The Risk of Osteoporosis and Osteoporotic Fracture Following the Use of Irritable Bowel Syndrome Medical Treatment: An Analysis Using the OMOP CDM Database. J. Clin. Med. 2021, 10, 2044. https://doi.org/10.3390/jcm10092044

AMA Style

Kim GL, Yi YH, Hwang HR, Kim J, Park Y, Kim YJ, Lee JG, Tak YJ, Lee SH, Lee SY, Cho YH, Park EJ, Lee Y. The Risk of Osteoporosis and Osteoporotic Fracture Following the Use of Irritable Bowel Syndrome Medical Treatment: An Analysis Using the OMOP CDM Database. Journal of Clinical Medicine. 2021; 10(9):2044. https://doi.org/10.3390/jcm10092044

Chicago/Turabian Style

Kim, Gyu L., Yu H. Yi, Hye R. Hwang, Jinmi Kim, Youngmin Park, Yun J. Kim, Jeong G. Lee, Young J. Tak, Seung H. Lee, Sang Y. Lee, Youn H. Cho, Eun J. Park, and Youngin Lee. 2021. "The Risk of Osteoporosis and Osteoporotic Fracture Following the Use of Irritable Bowel Syndrome Medical Treatment: An Analysis Using the OMOP CDM Database" Journal of Clinical Medicine 10, no. 9: 2044. https://doi.org/10.3390/jcm10092044

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