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Journal of Clinical Medicine, Volume 10, Issue 2

January-2 2021 - 207 articles

Cover Story: Endothelial dysfunction is a primary feature of several cardiovascular diseases. Endothelial colony-forming cells (ECFCs) represent a highly proliferative subtype of endothelial progenitor cells (EPCs), which are involved in neovascularization and vascular repair. Statins are known to improve the outcome of cardiovascular diseases via pleiotropic effects. Pravastatin induced effects were reversible by the addition of mevalonate. Pravastatin induces beneficial effects on ECFC function, angiogenic signaling and protein expression. These effects may contribute to understand the pleiotropic function of statins as well as to provide a promising option to improve ECFCs’ condition in cell therapy in order to ameliorate endothelial dysfunction. View this paper
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Articles (207)

  • Article
  • Open Access
16 Citations
3,591 Views
12 Pages

Contributing Factors to Perinatal Outcome in Pregnancies with Gestational Diabetes—What Matters Most? A Retrospective Analysis

  • Friederike Weschenfelder,
  • Friederike Hein,
  • Thomas Lehmann,
  • Ekkehard Schleußner and
  • Tanja Groten

18 January 2021

The aim of diabetes care of pregnant women with gestational diabetes mellitus (GDM) is to attain pregnancy outcomes including rates of large-for-gestational-age (LGA) newborns, pre-eclampsia, C-sections (CS) and other neonatal outcomes similar to tho...

  • Article
  • Open Access
69 Citations
9,122 Views
12 Pages

18 January 2021

Anxiety has been estimated to occur in 21–96% and depression in 27–79% of patients with chronic obstructive pulmonary disorder (COPD). We found a scarcity of literature providing evidence on how virtual reality (VR) therapy affects the in...

  • Article
  • Open Access
6 Citations
3,199 Views
9 Pages

18 January 2021

Background: Comprehensive pre-reoperative localization is essential in complicated persistent or recurrent renal hyperparathyroidism. The widely used imaging studies sometimes lead to ambiguous results. Our study aimed to clarify the role of tissue a...

  • Review
  • Open Access
45 Citations
6,287 Views
12 Pages

18 January 2021

Hepatic encephalopathy (HE) is a major complication of cirrhosis, which is associated with gut microbial composition and functional alterations. Current treatments largely focus on gut microbiota using lactulose, rifaximin and other agents. However,...

  • Review
  • Open Access
11 Citations
5,594 Views
27 Pages

18 January 2021

Retinopathy of prematurity (ROP), a vascular proliferative disease affecting preterm infants, is a leading cause of childhood blindness. Various studies have investigated the pathogenesis of ROP. Clinical experience indicates that oxygen levels are s...

  • Article
  • Open Access
4 Citations
2,971 Views
8 Pages

Severity by National Institute of Health Stroke Scale Score and Clinical Features of Stroke Patients with Patent Foramen Ovale Stroke and Atrial Fibrillation

  • Kaito Abe,
  • Fumiya Hasegawa,
  • Ryota Nakajima,
  • Hidetoshi Fukui,
  • Moto Shimada,
  • Takahiro Miyazaki,
  • Hiroshi Doi,
  • Goro Endo,
  • Kaori Kanbara and
  • Yasuyuki Mochida
  • + 5 authors

18 January 2021

The comparative severity of patent foramen ovale (PFO)-related stroke in patients without atrial fibrillation (AF) and AF-related stroke in patients without PFO is unknown. Therefore, we compared the severity of PFO-related stroke and AF-related stro...

  • Review
  • Open Access
26 Citations
3,605 Views
8 Pages

Are Lipids Possible Markers of Suicide Behaviors?

  • Agnieszka Kułak-Bejda,
  • Grzegorz Bejda,
  • Magdalena Lech and
  • Napoleon Waszkiewicz

18 January 2021

Suicides and suicidal behaviors are very important causes of mortality and morbidity and have become a serious global problem. More than 800,000 people die from suicide every year. Previous researches have established that lipids play an important ro...

  • Review
  • Open Access
8 Citations
2,593 Views
9 Pages

Clinical Impact of Lymphadenectomy after Neoadjuvant Chemotherapy in Advanced Epithelial Ovarian Cancer: A Review of Available Data

  • Stephanie Seidler,
  • Meriem Koual,
  • Guillaume Achen,
  • Enrica Bentivegna,
  • Laure Fournier,
  • Nicolas Delanoy,
  • Huyên-Thu Nguyen-Xuan,
  • Anne-Sophie Bats and
  • Henri Azaïs

18 January 2021

Recent robust data allow for omitting lymph node dissection for patients with advanced epithelial ovarian cancer (EOC) and without any suspicion of lymph node metastases, without compromising recurrence-free survival (RFS), nor overall survival (OS),...

  • Article
  • Open Access
8 Citations
2,329 Views
9 Pages

Evaluation of Myocardial Strain Using Cardiac Magnetic Resonance in Patients with Wilson’s Disease

  • Kun Zhang,
  • Ulrike Reuner,
  • Charlotte Hempel,
  • Uwe Speiser,
  • Karim Ibrahim,
  • Frank R. Heinzel,
  • Burkert Pieske,
  • Marian Christoph,
  • Felix M. Heidrich and
  • Silvio Quick

18 January 2021

(1) Background: Wilson’s disease (WD) is an inherited autosomal recessive disorder with the excessive deposition of copper into different organs, including the heart. Previous studies showed structural cardiac changes even in patients with no s...

  • Article
  • Open Access
12 Citations
3,934 Views
9 Pages

Femoral Revision Total Hip Arthroplasty Performed through the Interval of the Direct Anterior Approach

  • Martin Thaler,
  • Dietmar Dammerer,
  • Michael Ban,
  • Hermann Leitner,
  • Ismail Khosravi and
  • Michael Nogler

18 January 2021

Background: we report the clinical outcomes for femoral revision total hip replacement (THR) using the Direct Anterior Approach (DAA) interval. Methods: 149 patients (165 hips) with a mean age of 68.9 years (range, 33.2–91.0 years) and a mean f...

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J. Clin. Med. - ISSN 2077-0383