Comparison of COVID-19 and Non-COVID-19 Pneumonia in Down Syndrome
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design and Participants
2.2. Data Extraction
2.3. Statistical Analysis
3. Results
3.1. Socio-Demographic and Clinical Characteristics of the Spanish DS COVID-19 Patients
3.2. Comparison of COVID-19 and Other Pneumonia-Related Hospitalizations
3.3. Mortality Rates
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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COVID-19 Pneumonia | Non-COVID-19 Pneumonia | p | |
---|---|---|---|
n = 86 | n = 2832 | ||
Age (years) | 46.4 (11.8) | 42.2 (13.9) | <0.01 * |
(mean (SD)) | |||
16–40 years | 0.36 ** | ||
Women | 24 (27.9%) | 1251 (44.2%) | |
Men | 11 (45.8%) | 434 (34.7%) | |
(n (%)) | 13 (56.2%) | 817 (65.3%) | |
>40 years | 0.21 ** | ||
Women | 61 (72.1%) | 1581 (55.8%) | |
Men | 31 (50.8%) | 662 (41.9%) | |
(n (%)) | 30 (49.2%) | 919 (58.1%) | |
Length of stay | 10.3 (7.9) | 9.9 (9.4) | 0.79 ** |
(mean (SD)) | |||
Length of stay by discharge status (Days) (mean (SD)) | |||
Alive | 12.1 (8.2) | 9.8 (8.6) | <0.001 * |
Dead | 5.1 (3.3) | 11.9 (14.5) | 0.034 * |
DS and COVID-19 n = 86 n (%) | Non-COVID Pneumoniae n = 2832 n (%) | χ2 (p) | |
---|---|---|---|
Obesity | 22 (25.5) | 246 (8.7) | <0.001 |
Dementia | 22 (25.5) | 152 (5.4) | <0.001 |
Epilepsy | 9 (10.4) | 389 (13.7) | 0.7 |
COVID-19 Pneumonia n = 86 | Non-COVID Pneumoniae n = 2811 | p | |
---|---|---|---|
Overall in-hospital mortality rate (n (%)) | 23 (26.7) | 273 (9.7) | <0.001 * |
Age of deceased patients (mean (SD)) | 55.5 (5) | 49.1 (11.7) | <0.001 ** |
Proportion of deceased patients over 40 years (n (%)) | 23 (37) | 214 (13.7) | <0.001 * |
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Real de Asua, D.; Mayer, M.A.; Ortega, M.d.C.; Borrel, J.M.; Bermejo, T.d.J.; González-Lamuño, D.; Manso, C.; Moldenhauer, F.; Carmona-Iragui, M.; Hüls, A.; et al. Comparison of COVID-19 and Non-COVID-19 Pneumonia in Down Syndrome. J. Clin. Med. 2021, 10, 3748. https://doi.org/10.3390/jcm10163748
Real de Asua D, Mayer MA, Ortega MdC, Borrel JM, Bermejo TdJ, González-Lamuño D, Manso C, Moldenhauer F, Carmona-Iragui M, Hüls A, et al. Comparison of COVID-19 and Non-COVID-19 Pneumonia in Down Syndrome. Journal of Clinical Medicine. 2021; 10(16):3748. https://doi.org/10.3390/jcm10163748
Chicago/Turabian StyleReal de Asua, Diego, Miguel A. Mayer, María del Carmen Ortega, Jose M. Borrel, Teresa de Jesús Bermejo, Domingo González-Lamuño, Coral Manso, Fernando Moldenhauer, María Carmona-Iragui, Anke Hüls, and et al. 2021. "Comparison of COVID-19 and Non-COVID-19 Pneumonia in Down Syndrome" Journal of Clinical Medicine 10, no. 16: 3748. https://doi.org/10.3390/jcm10163748