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Advances in the Multi-Disciplinary Treatment of Head and Neck Cancer
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Advances in the Multi-Disciplinary Treatment of Head and Neck Cancer

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Oncology".

Deadline for manuscript submissions: closed (20 August 2021) | Viewed by 8499

Special Issue Editors

Prof. Dr. Alexandre Bozec

E-Mail Website
Guest Editor
1. Face and Neck University Institute (Institut Universitaire de la Face et du Cou), Antoine Lacassagne Center, 31, av de Valombroise, 06103 Nice, France
2. Faculty of Medecine, Côte d’Azur University, Nice, France
Interests: head and neck cancer; oncologic surgery; reconstructive surgery; quality of life
Special Issues, Collections and Topics in MDPI journals
Dr. Peter T. Dziegielewski

E-Mail Website
Guest Editor
Department of Otolaryngology, University of Florida, Gainesville, FL, USA

Special Issue Information

Dear Colleagues,

The treatment of head and neck cancers is rapidly evolving in all realms of oncology, including surgery, radiation oncology, chemotherapy, and immunotherapy. As patients are more likely to survive, many treatment groups have focused on functional outcomes, quality outcomes, maximal restoration of native form and function, quality of life, and minimizing toxicity. The aim of this Special Issue is to highlight the multi-disciplinary advances in head and neck cancer treatment that have recently occurred. The areas we would like to focus on include:

  • Human papillomavirus: New paradigms in the management of oropharyngeal cancers;
  • Current results and the role of immunotherapy;
  • The use of virtual surgical planning in head and neck reconstruction;
  • Trans-oral robotic surgery/trans-oral laser microsurgery;
  • Functional head and neck reconstruction;
  • Major ongoing and recently finished head and neck clinical trials;
  • Quality of care in head and neck radiation oncology;
  • Quality of care in head and neck surgical oncology;
  • The use of advanced radiation therapy techniques (IMRT, VMRT, IMPT).

We are soliciting original research articles and review articles covering any of the above or related topics.

Prof. Dr. Alexandre Bozec
Dr. Peter T. Dziegielewski
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • HPV+ oropharyngeal Cancer
  • De-escalation
  • 3D modelling/computer-aided surgery/virtual surgery
  • Robotic surgery
  • Functional outcomes
  • Quality of life outcomes
  • Proton therapy
  • Quality of care
  • Immunotherapy

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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14 pages, 8017 KiB  
Article
High-Resolution 18F-FDG PET/CT for Assessing Three-Dimensional Intraoperative Margins Status in Malignancies of the Head and Neck, a Proof-of-Concept
by Jens M. Debacker, Vanessa Schelfhout, Lieve Brochez, David Creytens, Yves D’Asseler, Philippe Deron, Vincent Keereman, Koen Van de Vijver, Christian Vanhove and Wouter Huvenne
J. Clin. Med. 2021, 10(16), 3737; https://doi.org/10.3390/jcm10163737 - 22 Aug 2021
Cited by 18 | Viewed by 4257
Abstract
The surgical treatment of head and neck malignancies relies on the complete removal of tumoral tissue, while inadequate margins necessitate the use of adjuvant therapy. However, most positive margins are identified postoperatively as deep margins, and intraoperative identification of the deep positive margins [...] Read more.
The surgical treatment of head and neck malignancies relies on the complete removal of tumoral tissue, while inadequate margins necessitate the use of adjuvant therapy. However, most positive margins are identified postoperatively as deep margins, and intraoperative identification of the deep positive margins could help achieve adequate surgical margins and decrease adjuvant therapies. To improve deep-margin identification, we investigated whether the use of high-resolution preclinical PET and CT could increase certainty about the surgical margins in three dimensions. Patients with a malignancy of the head and neck planned for surgical resection were administered a clinical activity of 4MBq/kg 18F-FDG approximately one hour prior to surgical initiation. Subsequently, the resected specimen was scanned with a micro-PET-CT imaging device, followed by histopathological assessment. Eight patients were included in the study and intraoperative PET/CT-imaging of 11 tumoral specimens and lymph nodes of three patients was performed. As a result of the increased resolution, differentiation between inflamed and dysplastic tissue versus malignant tissue was complicated in malignancies with increased peritumoral inflammation. The current technique allowed the three-dimensional delineation of 18F-FDG using submillimetric PET/CT imaging. While further optimization and patient stratification is required, clinical implementation could enable deep margin assessment in head and neck resection specimens. Full article
(This article belongs to the Special Issue Advances in the Multi-Disciplinary Treatment of Head and Neck Cancer)
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Review

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11 pages, 276 KiB  
Review
New Challenges of Treatment for Locally Advanced Head and Neck Cancers in the Covid-19 Pandemic Era
by Camil Ciprian Mireștean, Anda Crișan, Adina Mitrea, Călin Buzea, Roxana Irina Iancu and Dragoș Petru Teodor Iancu
J. Clin. Med. 2021, 10(4), 587; https://doi.org/10.3390/jcm10040587 - 4 Feb 2021
Cited by 2 | Viewed by 3365
Abstract
Locally advanced head and neck cancer is a unique challenge for cancer management in the Covid-19 situation. The negative consequences of delaying radio-chemotherapy treatment make it necessary to prioritize these patients, the continuation of radiotherapy being indicated even if SARS-CoV-2 infection is confirmed [...] Read more.
Locally advanced head and neck cancer is a unique challenge for cancer management in the Covid-19 situation. The negative consequences of delaying radio-chemotherapy treatment make it necessary to prioritize these patients, the continuation of radiotherapy being indicated even if SARS-CoV-2 infection is confirmed in the case of patients with moderate and mild symptoms. For an early scenario, the standard chemo-radiotherapy using simultaneous integrated boost (SIB) technique is the preferred option, because it reduces the overall treatment time. For a late scenario with limited resources, hypo-fractionated treatment, with possible omission of chemotherapy for elderly patients and for those who have comorbidities, is recommended. Concurrent chemotherapy is controversial for dose values >2.4 Gy per fraction. The implementation of hypo-fractionated regimens should be based on a careful assessment of dose-volume constraints for organs at risks (OARs), using recommendations from clinical trials or dose conversion based on the linear-quadratic (LQ) model. Induction chemotherapy is not considered the optimal solution in this situation because of the risk of immunosuppression even though in selected groups of patients TPF regimen may bring benefits. Although the MACH-NC meta-analysis of chemotherapy in head and neck cancers did not demonstrate the superiority of induction chemotherapy over concurrent chemoradiotherapy, an induction regimen could be considered for cases with an increased risk of metastasis even in the case of a possible Covid-19 pandemic scenario. Full article
(This article belongs to the Special Issue Advances in the Multi-Disciplinary Treatment of Head and Neck Cancer)
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