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Vaccines, Volume 11, Issue 4

April 2023 - 169 articles

Cover Story: Radioresistance is a major barrier to achieving efficient local tumor control. The combination of radiotherapy (RT) with immunotherapy has improved outcomes for patients with solid tumors. It becomes important to understand how radiation modulates immune mechanisms of radioresistance. We summarize how radiation modulates the expression and activation of Toll-Like Receptors in the tumor microenvironment. Radiation induces the release of damage associated molecular patterns from damaged or dying cells. DAMPs can be recognized by pattern recognition receptors such as TLRs. This triggers a signaling cascade that results in a pro- or anti-tumor effect, depending on the specific TLR and the type of cancer. The rational combination of TLR-based therapies with RT can enhance tumor recognition by antigen-presenting cells and lead to sustained antitumor immunity and effective local tumor control. View this paper
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Articles (169)

  • Article
  • Open Access
7 Citations
3,360 Views
12 Pages

Views and Perceptions of People Aged 55+ on the Vaccination Programme for Older Adults in the UK: A Qualitative Study

  • Taru Silvonen,
  • Jo Kesten,
  • Christie Cabral,
  • Jo Coast,
  • Yoav Ben-Shlomo and
  • Hannah Christensen

20 April 2023

Vaccination reduces the risks related to infectious disease, especially among more vulnerable groups, such as older adults. The vaccines available to older adults in the UK through the government-funded programme currently include influenza, pneumoco...

  • Brief Report
  • Open Access
3 Citations
2,460 Views
10 Pages

SARS-CoV-2 Neutralizing Antibodies to B.1 and to BA.5 Variant after Booster Dose of BNT162b2 Vaccine in HIV Patients COVID-Naïve and on Successful Antiretroviral Therapy

  • Ilaria Vicenti,
  • Monica Basso,
  • Nicole Pirola,
  • Beatrice Bragato,
  • Maria Cristina Rossi,
  • Mario Giobbia,
  • Susanna Pascoli,
  • Antonio Vinci,
  • Sara Caputo and
  • Ilenia Varasi
  • + 4 authors

20 April 2023

Live virus neutralization is the gold standard to investigate immunity. This prospective observational study aimed to determine the magnitude of response against the original B.1 lineage and against the BA.5 lineage six months after the third BNT162b...

  • Systematic Review
  • Open Access
21 Citations
5,513 Views
22 Pages

19 April 2023

Maternal vaccination is considered a key component of the antenatal care package for improving maternal and child health. Low- and middle-income countries (LMICs) fall short of global targets to prevent maternal and neonatal deaths, with a disproport...

  • Article
  • Open Access
4 Citations
3,411 Views
17 Pages

Examining the Impact of Key Factors on COVID-19 Vaccination Coverage in India: A PLS-SEM Approach

  • Veena Dhawan,
  • Mahesh Kumar Aggarwal,
  • Pritu Dhalaria,
  • Preeti Kharb,
  • Deepika Sharma,
  • Kamala Kannan Dinesh,
  • Sanjay Dhir,
  • Sushil,
  • Gunjan Taneja and
  • Raj Shankar Ghosh

19 April 2023

During the coronavirus disease 2019 (COVID-19) pandemic, numerous factors determined the performance of COVID-19 vaccination coverage. The purpose of this study is to examine the influence of factors such as government stewardship, planning and imple...

  • Article
  • Open Access
3 Citations
3,202 Views
13 Pages

Genomic Analysis of Infectious Bursal Disease Virus in Nigeria: Identification of Unique Mutations of Yet Unknown Biological Functions in Both Segments A and B

  • Ijeoma Nwagbo,
  • Adelaide Milani,
  • Annalisa Salviato,
  • Gianpiero Zamperin,
  • Lanre Sulaiman,
  • Nanven Maurice,
  • Clement Meseko,
  • Alice Fusaro and
  • Ismaila Shittu

19 April 2023

Infectious bursal disease (IBD) is a viral poultry disease known worldwide for impacting the economy and food security. The disease is endemic in Nigeria, with reported outbreaks in vaccinated poultry flocks. To gain insight into the dynamics of infe...

  • Article
  • Open Access
6 Citations
4,284 Views
13 Pages

Dissolving Microneedles Loaded with Nanoparticle Formulation of Respiratory Syncytial Virus Fusion Protein Virus-like Particles (F-VLPs) Elicits Cellular and Humoral Immune Responses

  • Ipshita Menon,
  • Smital Patil,
  • Priyal Bagwe,
  • Sharon Vijayanand,
  • Akanksha Kale,
  • Keegan Braz Gomes,
  • Sang Moo Kang and
  • Martin D’Souza

18 April 2023

Respiratory syncytial virus (RSV) is one of the leading causes of bronchiolitis and pneumonia in children ages five years and below. Recent outbreaks of the virus have proven that RSV remains a severe burden on healthcare services. Thus, a vaccine fo...

  • Article
  • Open Access
14 Citations
3,543 Views
16 Pages

18 April 2023

Pullorum disease, caused by the Salmonella enterica serovar Gallinarum biovar Pullorum, is a highly contagious disease in the poultry industry, leading to significant economic losses in many developing countries. Due to the emergence of multidru...

  • Article
  • Open Access
5 Citations
3,337 Views
17 Pages

Combination of Recombinant Proteins S1/N and RBD/N as Potential Vaccine Candidates

  • Noe Juvenal Mendoza-Ramírez,
  • Julio García-Cordero,
  • Sandra Paola Martínez-Frías,
  • Daniela Roa-Velázquez,
  • Rosendo Luria-Pérez,
  • José Bustos-Arriaga,
  • Jesús Hernández-Lopez,
  • Carlos Cabello-Gutiérrez,
  • Joaquín Alejandro Zúñiga-Ramos and
  • Edgar Morales-Ríos
  • + 3 authors

18 April 2023

Despite all successful efforts to develop a COVID-19 vaccine, the need to evaluate alternative antigens to produce next-generation vaccines is imperative to target emerging variants. Thus, the second generation of COVID-19 vaccines employ more than o...

  • Systematic Review
  • Open Access
4 Citations
2,935 Views
15 Pages

Effectiveness, Immunogenicity and Harms of Additional SARS-CoV-2 Vaccine Doses in Kidney Transplant Recipients: A Systematic Review

  • Renate Ilona Hausinger,
  • Quirin Bachmann,
  • Timotius Crone-Rawe,
  • Nora Hannane,
  • Ina Monsef,
  • Bernhard Haller,
  • Uwe Heemann,
  • Nicole Skoetz,
  • Nina Kreuzberger and
  • Christoph Schmaderer

18 April 2023

Background: Kidney transplant recipients (KTRs) who have a highly impaired immune response are in need of intensified and safe vaccination strategies to achieve seroconversion and prevent severe disease. Methods: We searched the Web of Science Core C...

  • Brief Report
  • Open Access
2 Citations
3,202 Views
9 Pages

18 April 2023

Objective: To assess the immunogenicity and safety of the enterovirus 71 vaccine (Vero cell) (EV71 vaccine) and trivalent split-virion influenza vaccine (IIV3). Methods: Healthy infants aged 6–7 months were recruited from Zhejiang Province, Henan Pro...

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Vaccines - ISSN 2076-393X