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Vaccines, Volume 11, Issue 4

April 2023 - 169 articles

Cover Story: Radioresistance is a major barrier to achieving efficient local tumor control. The combination of radiotherapy (RT) with immunotherapy has improved outcomes for patients with solid tumors. It becomes important to understand how radiation modulates immune mechanisms of radioresistance. We summarize how radiation modulates the expression and activation of Toll-Like Receptors in the tumor microenvironment. Radiation induces the release of damage associated molecular patterns from damaged or dying cells. DAMPs can be recognized by pattern recognition receptors such as TLRs. This triggers a signaling cascade that results in a pro- or anti-tumor effect, depending on the specific TLR and the type of cancer. The rational combination of TLR-based therapies with RT can enhance tumor recognition by antigen-presenting cells and lead to sustained antitumor immunity and effective local tumor control. View this paper
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Articles (169)

  • Article
  • Open Access
9 Citations
3,552 Views
21 Pages
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Protective Efficacy of Multiple Epitope-Based Vaccine against Hyalomma anatolicum, Vector of Theileria annulata and Crimean–Congo Hemorrhagic Fever Virus

  • Abhijit Nandi,
  • Manisha,
  • Vandana Solanki,
  • Vishvanath Tiwari,
  • Basavaraj Sajjanar,
  • Muthu Sankar,
  • Mohini Saini,
  • Sameer Shrivastava,
  • S. K. Bhure and
  • Srikant Ghosh
Vaccines2023, 11(4), 881;https://doi.org/10.3390/vaccines11040881

21 April 2023

Hyalomma anatolicum is the principal vector for Theileria annulata, T. equi, and T. Lestoquardi in animals and the Crimean–Congo hemorrhagic fever virus in humans. Due to the gradual loss of efficacy of the available acaricides against field ti...

Full Article
  • Brief Report
  • Open Access
10 Citations
9,409 Views
9 Pages
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Differences in the Expression Levels of SARS-CoV-2 Spike Protein in Cells Treated with mRNA-Based COVID-19 Vaccines: A Study on Vaccines from the Real World

  • Luigi Cari,
  • Mahdieh Naghavi Alhosseini,
  • Antonella Mencacci,
  • Graziella Migliorati and
  • Giuseppe Nocentini
Vaccines2023, 11(4), 879;https://doi.org/10.3390/vaccines11040879

21 April 2023

Comirnaty (BNT162b2) and Spikevax (mRNA-1273) COVID-19 vaccines encode a full-length SARS-CoV-2 Spike (S) protein. To evaluate whether the S-protein expressed following treatment with the two vaccines differs in the real-world context, two cell lines...

Full Article
  • Systematic Review
  • Open Access
23 Citations
10,790 Views
28 Pages
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Healthcare Workers’ Attitudes towards Mandatory COVID-19 Vaccination: A Systematic Review and Meta-Analysis

  • Marios Politis,
  • Sotiris Sotiriou,
  • Chrysoula Doxani,
  • Ioannis Stefanidis,
  • Elias Zintzaras and
  • Georgios Rachiotis
Vaccines2023, 11(4), 880;https://doi.org/10.3390/vaccines11040880

21 April 2023

Background: COVID-19 vaccine mandates are considered a controversial public health policy both in public debate and among healthcare workers (HCWs). Thus, the objective of this systematic review is to give a deep insight into HCWs’ views and at...

Full Article
  • Article
  • Open Access
11 Citations
4,445 Views
17 Pages
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Knowledge of Community Pharmacists in Saudi Arabia Regarding Human Monkeypox, Its Management, Prevention, and Vaccination: Findings and Implications

  • Alian A. Alrasheedy,
  • Abdulrahman H. Aldawsari,
  • Munyib I. Alqasir,
  • Omar A. Alsawyan,
  • Osama A. Alalwan,
  • Saleh A. Alwaker,
  • Masaad S. Almutairi and
  • Brian Godman
Vaccines2023, 11(4), 878;https://doi.org/10.3390/vaccines11040878

21 April 2023

Many cases of monkeypox have recently been reported in countries where this disease is not endemic, raising a global health concern. Consequently, healthcare professionals (HCPs), including pharmacists, need to be aware of the disease, its prevention...

Full Article
  • Article
  • Open Access
1 Citations
2,849 Views
18 Pages
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Innate Immune Response Assessment in Cyprinus carpio L. upon Experimental Administration with Artemia salina Bio-Encapsulated Aeromonas hydrophila Bacterin

  • Akshaya Radhakrishnan,
  • D. S. Prabakaran,
  • Thiyagarajan Ramesh,
  • Ramalingam Sakthivel,
  • Kavikumar Ramasamy,
  • Hyo-Shim Han and
  • Sivakamavalli Jeyachandran
Vaccines2023, 11(4), 877;https://doi.org/10.3390/vaccines11040877

21 April 2023

The present study aimed to analyze the enhancement of innate immune responses in juvenile-stage common carp (Cyprinus carpio L.), upon the administration of heat-killed Aeromonas hydrophila at a dosage of 1 × 107 CFU ml−1 through bio-enca...

Full Article
  • Communication
  • Open Access
1 Citations
1,895 Views
6 Pages
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Bolstering the Measurement of Racial Inequity of COVID-19 Vaccine Uptake

  • Savanah Russ,
  • John Bramley,
  • Yu Liu and
  • Irena Boyce
Vaccines2023, 11(4), 876;https://doi.org/10.3390/vaccines11040876

21 April 2023

Inequities in COVID-19 vaccine uptake by racialized groups have been persistent throughout the vaccine rollout, leading to disparate burdens of COVID-19 outcomes. A cross-sectional study was conducted to determine COVID-19 vaccine uptake across racia...

Full Article
  • Review
  • Open Access
23 Citations
7,230 Views
11 Pages
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Immune Imprinting and Implications for COVID-19

  • Zhiqian Zhou,
  • Julia Barrett and
  • Xuan He
Vaccines2023, 11(4), 875;https://doi.org/10.3390/vaccines11040875

20 April 2023

Immunological memory is the key source of protective immunity against pathogens. At the current stage of the COVID-19 pandemic, heterologous combinations of exposure to viral antigens during infection and/or vaccination shape a distinctive immunologi...

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  • Article
  • Open Access
14 Citations
4,489 Views
20 Pages
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Immunogenicity and In Vivo Protective Effects of Recombinant Nucleocapsid-Based SARS-CoV-2 Vaccine Convacell®

  • Sevastyan O. Rabdano,
  • Ellina A. Ruzanova,
  • Iuliia V. Pletyukhina,
  • Nikita S. Saveliev,
  • Kirill L. Kryshen,
  • Anastasiia E. Katelnikova,
  • Petr P. Beltyukov,
  • Liliya N. Fakhretdinova,
  • Ariana S. Safi and
  • German O. Rudakov
  • + 11 authors
Vaccines2023, 11(4), 874;https://doi.org/10.3390/vaccines11040874

20 April 2023

The vast majority of SARS-CoV-2 vaccines which are licensed or under development focus on the spike (S) protein and its receptor binding domain (RBD). However, the S protein shows considerable sequence variations among variants of concern. The aim of...

Full Article
  • Systematic Review
  • Open Access
25 Citations
4,622 Views
33 Pages
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Factors Influencing the Intention and Uptake of COVID-19 Vaccines on the African Continent: A Scoping Review

  • Damian Naidoo,
  • Anna Meyer-Weitz and
  • Kaymarlin Govender
Vaccines2023, 11(4), 873;https://doi.org/10.3390/vaccines11040873

20 April 2023

The COVID-19 pandemic is a severe concern worldwide, particularly in Africa. Vaccines are crucial in the fight against the COVID-19 pandemic. This scoping review examined existing literature from 2020 to 2022 on individual, interpersonal, and structu...

Full Article
  • Article
  • Open Access
11 Citations
4,489 Views
12 Pages
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Using Electronic Reminders to Improve Human Papillomavirus (HPV) Vaccinations among Primary Care Patients

  • Kathleen Hanley,
  • Tong Han Chung,
  • Linh K. Nguyen,
  • Tochi Amadi,
  • Sandra Stansberry,
  • Robert J. Yetman,
  • Lewis E. Foxhall,
  • Rosalind Bello,
  • Talhatou Diallo and
  • Yen-Chi L. Le
Vaccines2023, 11(4), 872;https://doi.org/10.3390/vaccines11040872

20 April 2023

The COVID-19 pandemic led to delays in routine preventative primary care and declines in HPV immunization rates. Providers and healthcare organizations needed to explore new ways to engage individuals to resume preventive care behaviors. Thus, we eva...

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