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Antioxidants, Volume 13, Issue 8

August 2024 - 143 articles

Cover Story: The linkage between antioxidants and calcification prevention. This study reveals how Nrf2, a key regulator of cellular antioxidant responses, fights ectopic calcification by upregulating ENPP1, an enzyme crucial for producing pyrophosphate, a calcification inhibitor. Through in vitro and in vivo experiments, including a mouse model of spinal ligament ossification, researchers show how Nrf2 activation effectively suppresses abnormal calcification. This work illuminates a novel connection between antioxidant systems and calcification, proposing innovative strategies for treating related diseases. By bridging oxidative stress research and calcification disorders, it opens new avenues for antioxidant studies, appealing to scientists and clinicians exploring ways to prevent harmful calcification. View this paper
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Articles (143)

  • Article
  • Open Access
6 Citations
1,950 Views
16 Pages

22 August 2024

Honokiol, a biphenyl lignan extracted from bark extracts belonging to Magnolia plant species, is a pleiotropic compound which exhibits a widespread range of antioxidant, antibacterial, antidiabetic, anti-inflammatory, antiaggregant, analgesic, antitu...

  • Article
  • Open Access
5 Citations
1,868 Views
12 Pages

Avicularin Attenuated Lead-Induced Ferroptosis, Neuroinflammation, and Memory Impairment in Mice

  • Jun-Tao Guo,
  • Chao Cheng,
  • Jia-Xue Shi,
  • Wen-Ting Zhang,
  • Han Sun and
  • Chan-Min Liu

22 August 2024

Lead (Pb) is a common environmental neurotoxicant that results in abnormal neurobehavior and impaired memory. Avicularin (AVL), the main dietary flavonoid found in several plants and fruits, exhibits neuroprotective and hepatoprotective properties. I...

  • Article
  • Open Access
5 Citations
3,429 Views
38 Pages

A Multi-Target Pharmacological Correction of a Lipoyltransferase LIPT1 Gene Mutation in Patient-Derived Cellular Models

  • David Gómez-Fernández,
  • Ana Romero-González,
  • Juan M. Suárez-Rivero,
  • Paula Cilleros-Holgado,
  • Mónica Álvarez-Córdoba,
  • Rocío Piñero-Pérez,
  • José Manuel Romero-Domínguez,
  • Diana Reche-López,
  • Alejandra López-Cabrera and
  • Salvador Ibáñez-Mico
  • + 5 authors

22 August 2024

Mutations in the lipoyltransferase 1 (LIPT1) gene are rare inborn errors of metabolism leading to a fatal condition characterized by lipoylation defects of the 2-ketoacid dehydrogenase complexes causing early-onset seizures, psychomotor retardation,...

  • Article
  • Open Access
1,452 Views
20 Pages

22 August 2024

Rapeseed (Brassica napus L.) seedlings suffering from inappropriate growth substrate stress will present poor seedling quality. However, the regulatory mechanism for the production and scavenging of reactive oxygen species (ROS) caused by this type o...

  • Article
  • Open Access
1 Citations
2,157 Views
13 Pages

Paraoxonase I Activity and Its Relationship with Nutrition in Amyotrophic Lateral Sclerosis

  • Belén Proaño,
  • María Benlloch,
  • Sandra Sancho-Castillo,
  • Jesús Privado,
  • Guillermo Bargues-Navarro,
  • Claudia Emmanuela Sanchis-Sanchis,
  • Palmira Martínez Bolós,
  • Ana Belén Carriquí-Suárez,
  • Laura Cubero-Plazas and
  • Jose Luis Platero Armero
  • + 4 authors

22 August 2024

Background: Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration, with oxidative stress playing a key role. Paraoxonase 1 (PON1) is an antioxidant enzyme that may influence ALS progression. This study aimed to...

  • Article
  • Open Access
3 Citations
2,186 Views
18 Pages

22 August 2024

Environmental stressors can induce paternal epigenetic modifications that are a key determinant of the intergenerational inheritance of acquired phenotypes in mammals. Some of them can affect phenotypic expression through inducing changes in tRNA-der...

  • Article
  • Open Access
6 Citations
2,693 Views
23 Pages

21 August 2024

Skin aging is associated with the increased production of mitochondrial reactive oxygen species (mtROS) due to mitochondrial dysfunction, and various phytonutrients and estrogens have been shown to improve skin health. Thus, the aim of the current st...

  • Article
  • Open Access
1,542 Views
16 Pages

Effect of Supplementation of a Cryopreservation Extender with Pectoliv30 on Post-Thawing Semen Quality Parameters in Rooster Species

  • Esther Díaz Ruiz,
  • Juan Vicente Delgado Bermejo,
  • José Manuel León Jurado,
  • Francisco Javier Navas González,
  • Ander Arando Arbulu,
  • Juan Fernández-Bolaños Guzmán,
  • Alejandra Bermúdez Oria and
  • Antonio González Ariza

21 August 2024

Sperm cryopreservation is a fundamental tool for the conservation of avian genetic resources; however, avian spermatozoa are susceptible to this process. To cope with the high production of reactive oxygen species (ROS), the addition of exogenous ant...

  • Review
  • Open Access
5 Citations
3,456 Views
12 Pages

The Role of Oxidative Stress in Hypomagnetic Field Effects

  • Lanxiang Tian,
  • Yukai Luo,
  • Jie Ren and
  • Chenchen Zhao

21 August 2024

The geomagnetic field (GMF) is crucial for the survival and evolution of life on Earth. The weakening of the GMF, known as the hypomagnetic field (HMF), significantly affects various aspects of life on Earth. HMF has become a potential health risk fo...

  • Article
  • Open Access
12 Citations
3,250 Views
20 Pages

Phytochemical Composition Antioxidant and Anti-Inflammatory Activity of Artemisia dracunculus and Artemisia abrotanum

  • Mădălina Țicolea,
  • Raluca Maria Pop,
  • Marcel Pârvu,
  • Lia-Oxana Usatiuc,
  • Ana Uifălean,
  • Floricuța Ranga and
  • Alina Elena Pârvu

20 August 2024

This study aimed to investigate the antioxidant and anti-inflammatory activities mechanism of Artemisia dracunculus (A. dracunculus) and Artemisia abrotanum (A. abrotanum) ethanol extracts in acute rat inflammation induced in Wistar male rats with tu...

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Antioxidants - ISSN 2076-3921