Brain Sciences, Volume 8, Issue 7
2018 July - 23 articles
Cover Story: Brain-derived neurotrophic factor (BDNF) is a mediator of neurogenesis necessary for medium spiny striatal neuron survival and signaling, especially in later life. In prodromal and diagnosed Huntington Disease (HD), striatal (and possibly frontal) BDNF is reduced relative to controls, and BDNF transcription and retrograde transport are disrupted. Here, we show that prodromal individuals with high or low levels of a genetic profile highlighting NTRK2, which encodes BDNF’s primary TrkB receptor, respectively display increases or reductions in movement-related frontal gray matter that is positively associated with motor and cognitive functioning. The cover image shows the genes and brain regions that contribute most to these effects.
- Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
- You may sign up for email alerts to receive table of contents of newly released issues.
- PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.