Table of Contents
Brain Sci., Volume 8, Issue 7 (July 2018)
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Cover Story (view full-size image) Brain-derived neurotrophic factor (BDNF) is a mediator of neurogenesis necessary for medium spiny [...] Read more. Brain-derived neurotrophic factor (BDNF) is a mediator of neurogenesis necessary for medium spiny striatal neuron survival and signaling, especially in later life. In prodromal and diagnosed Huntington Disease (HD), striatal (and possibly frontal) BDNF is reduced relative to controls, and BDNF transcription and retrograde transport are disrupted. Here, we show that prodromal individuals with high or low levels of a genetic profile highlighting NTRK2, which encodes BDNF’s primary TrkB receptor, respectively display increases or reductions in movement-related frontal gray matter that is positively associated with motor and cognitive functioning. The cover image shows the genes and brain regions that contribute most to these effects.