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Brain Sciences, Volume 8, Issue 7

2018 July - 23 articles

Cover Story: Brain-derived neurotrophic factor (BDNF) is a mediator of neurogenesis necessary for medium spiny striatal neuron survival and signaling, especially in later life. In prodromal and diagnosed Huntington Disease (HD), striatal (and possibly frontal) BDNF is reduced relative to controls, and BDNF transcription and retrograde transport are disrupted. Here, we show that prodromal individuals with high or low levels of a genetic profile highlighting NTRK2, which encodes BDNF’s primary TrkB receptor, respectively display increases or reductions in movement-related frontal gray matter that is positively associated with motor and cognitive functioning. The cover image shows the genes and brain regions that contribute most to these effects.
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Articles (23)

  • Review
  • Open Access
42 Citations
8,543 Views
14 Pages

Transcranial Current Stimulations (tCSs) are non-invasive brain stimulation techniques which modulate cortical excitability and spontaneous brain activity by the application of weak electric currents through the scalp, in a safe, economic, and well-t...

  • Article
  • Open Access
4 Citations
4,992 Views
8 Pages

Hereditary spastic paraplegia (HSP) is one of the most genetically heterogeneous neurological disorders. HSP is classified as pure when only a spastic weakness of the lower extremities is present. Complex HSP comes with additional neurological or sys...

  • Article
  • Open Access
30 Citations
7,423 Views
19 Pages

A Pilot Study Investigating a Novel Non-Linear Measure of Eyes Open versus Eyes Closed EEG Synchronization in People with Alzheimer’s Disease and Healthy Controls

  • Daniel J. Blackburn,
  • Yifan Zhao,
  • Matteo De Marco,
  • Simon M. Bell,
  • Fei He,
  • Hua-Liang Wei,
  • Sarah Lawrence,
  • Zoe C. Unwin,
  • Michelle Blyth and
  • Ptolemaios G. Sarrigiannis
  • + 6 authors

Background: The incidence of Alzheimer disease (AD) is increasing with the ageing population. The development of low cost non-invasive diagnostic aids for AD is a research priority. This pilot study investigated whether an approach based on a novel d...

  • Article
  • Open Access
40 Citations
6,930 Views
12 Pages

Pediatric Deep Brain Stimulation Using Awake Recording and Stimulation for Target Selection in an Inpatient Neuromodulation Monitoring Unit

  • Terence D. Sanger,
  • Mark Liker,
  • Enrique Arguelles,
  • Ruta Deshpande,
  • Arash Maskooki,
  • Diana Ferman,
  • Aprille Tongol and
  • Aaron Robison

Deep brain stimulation (DBS) for secondary (acquired, combined) dystonia does not reach the high degree of efficacy achieved in primary (genetic, isolated) dystonia. We hypothesize that this may be due to variability in the underlying injury, so that...

  • Article
  • Open Access
23 Citations
6,540 Views
10 Pages

Synthetic Cannabinoid use in a Case Series of Patients with Psychosis Presenting to Acute Psychiatric Settings: Clinical Presentation and Management Issues

  • Stefania Bonaccorso,
  • Antonio Metastasio,
  • Angelo Ricciardi,
  • Neil Stewart,
  • Leila Jamal,
  • Naasir-Ud-Dinn Rujully,
  • Christos Theleritis,
  • Stefano Ferracuti,
  • Giuseppe Ducci and
  • Fabrizio Schifano

Background: Novel Psychoactive Substances (NPS) are a heterogeneous class of synthetic molecules including synthetic cannabinoid receptor agonists (SCRAs). Psychosis is associated with SCRAs use. There is limited knowledge regarding the structured as...

  • Article
  • Open Access
7 Citations
5,398 Views
16 Pages

The basal forebrain has received much attention due to its involvement in multiple cognitive functions, but little is known about the basic neuronal mechanisms underlying its development, nor those mediating its primary role in Alzheimer’s dise...

  • Article
  • Open Access
30 Citations
10,068 Views
17 Pages

Although perceived discrimination in Black youth is a risk factor for a wide range of negative mental health outcomes, recent research has suggested some gender differences in these associations. Gender differences in vulnerability to perceived discr...

  • Article
  • Open Access
10 Citations
5,448 Views
18 Pages

Code-VEP vs. Eye Tracking: A Comparison Study

  • Hooman Nezamfar,
  • Seyed Sadegh Mohseni Salehi,
  • Matt Higger and
  • Deniz Erdogmus

Even with state-of-the-art techniques there are individuals whose paralysis prevents them from communicating with others. Brain–Computer-Interfaces (BCI) aim to utilize brain waves to construct a voice for those whose needs remain unmet. In thi...

  • Review
  • Open Access
36 Citations
7,623 Views
12 Pages

Background. Tourette syndrome (TS) is a childhood-onset neuropsychiatric disorder consisting of impairing motor and vocal tics which often persists adolescent and adult years. In this older refractory group, standard treatments such as pharmacotherap...

  • Article
  • Open Access
31 Citations
7,583 Views
11 Pages

Trait Emotional Empathy and Resting State Functional Connectivity in Default Mode, Salience, and Central Executive Networks

  • Elena Bilevicius,
  • Tiffany A. Kolesar,
  • Stephen D. Smith,
  • Paul D. Trapnell and
  • Jennifer Kornelsen

Emotional empathy is the ability to experience and/or share another person’s emotional states and responses. Although some research has examined the neural correlates of emotional empathy, there has been little research investigating whether th...

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Brain Sci. - ISSN 2076-3425