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Brain Sciences, Volume 8, Issue 6

June 2018 - 21 articles

Cover Story: Timely and efficient remyelination following demyelinating diseases of the central nervous system such as Multiple Sclerosis is a key component in targeted reparative therapies. The cover page shows a representative electron microscopy image of dorsal white matter in an adult rat spinal cord following lysolecithin (lysophosphatidylcholine—LPC) injection. There is evidence of spontaneous remyelination, albeit with thinner myelin sheaths than those formed during development. In this review, we provide an overview of normal myelination during development, causes for demyelination, and an in-depth discussion of the current and potential future strategies for promoting remyelination.
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Articles (21)

  • Review
  • Open Access
91 Citations
12,347 Views
13 Pages

The gut microbiome and its role in health and disease have recently been major focus areas of research. In this review, we summarize the different ways in which the gut microbiome interacts with the rest of the body, with focus areas on its relations...

  • Review
  • Open Access
50 Citations
11,117 Views
23 Pages

Statistical learning (SL) is a method of learning based on the transitional probabilities embedded in sequential phenomena such as music and language. It has been considered an implicit and domain-general mechanism that is innate in the human brain a...

  • Article
  • Open Access
3 Citations
4,668 Views
10 Pages

Traumatic brain injury (TBI) affects 1.9 million Americans, including blast TBI that is the signature injury of the Iraq and Afghanistan wars. Our project investigated whether stromal vascular fraction (SVF) can assist in post-TBI recovery. We utiliz...

  • Review
  • Open Access
37 Citations
8,551 Views
19 Pages

Myelination is critical for the normal functioning of the central nervous system (CNS) in vertebrates. Conditions in which the development of myelin is perturbed result in severely compromised individuals often with shorter lifespans, while loss of m...

  • Article
  • Open Access
16 Citations
5,308 Views
13 Pages

Chaperonology: The Third Eye on Brain Gliomas

  • Francesca Graziano,
  • C. Caruso Bavisotto,
  • A. Marino Gammazza,
  • Francesca Rappa,
  • Everly Conway De Macario,
  • Albert J. L. Macario,
  • Francesco Cappello,
  • Claudia Campanella,
  • Rosario Maugeri and
  • Domenico Gerardo Iacopino

The European Organization for Research and Treatment of Cancer/National Cancer Institute of Canada Phase III trial has validated as a current regimen for high-grade gliomas (HGG) a maximal safe surgical resection followed by radiotherapy with concurr...

  • Review
  • Open Access
45 Citations
7,141 Views
10 Pages

Following an initial mechanical insult, traumatic spinal cord injury (SCI) induces a secondary wave of injury, resulting in a toxic lesion environment inhibitory to axonal regeneration. This review focuses on the glial cell line-derived neurotrophic...

  • Review
  • Open Access
60 Citations
24,204 Views
14 Pages

Brain Connectivity Networks and the Aesthetic Experience of Music

  • Mark Reybrouck,
  • Peter Vuust and
  • Elvira Brattico

Listening to music is above all a human experience, which becomes an aesthetic experience when an individual immerses himself/herself in the music, dedicating attention to perceptual-cognitive-affective interpretation and evaluation. The study of the...

  • Article
  • Open Access
68 Citations
9,894 Views
17 Pages

Depression among Black Youth; Interaction of Class and Place

  • Shervin Assari,
  • Frederick X. Gibbons and
  • Ronald Simons

Although high socioeconomic status (SES) is traditionally conceptualized as a health protective factor, recent literature has documented positive associations between SES (e.g., income) and depression among Blacks, including Black youth. To extend th...

  • Review
  • Open Access
128 Citations
12,822 Views
24 Pages

Neuroprotective and Cognitive Enhancement Potentials of Baicalin: A Review

  • Kandhasamy Sowndhararajan,
  • Ponnuvel Deepa,
  • Minju Kim,
  • Se Jin Park and
  • Songmun Kim

Neurodegenerative diseases are a heterogeneous group of disorders that are characterized by the gradual loss of neurons. The development of effective neuroprotective agents to prevent and control neurodegenerative diseases is specifically important....

  • Article
  • Open Access
6 Citations
5,598 Views
12 Pages

Background. Poor self-esteem is a core element of depression. According to recent research, some racial groups may vary in the magnitude of the link between depression and poor self-esteem. Using a national sample, we compared Black and White older A...

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Brain Sci. - ISSN 2076-3425