Table of Contents
Brain Sci., Volume 8, Issue 4 (April 2018) – 26 articles
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Cover Story (view full-size image) The cover image shows a representation of the molecular model of the dopamine transporter (DAT) and [...] Read more. The cover image shows a representation of the molecular model of the dopamine transporter (DAT) and important residues in the primary binding pocket. We discuss in vitro and in silico approaches distinguishing the pharmacological, functional and structural changes of the novel psychoactive substances (NPS), diphenidine (DPH) and 2-methoxydiphenidine (2-MXP), when bound to DAT. Our data suggest that DPH can have addictive liability, unlike 2-MXP, despite their chemical similarities. The computational findings corroborate the above and explain the conformational responses and atomistic processes within DAT during its interactions with the dissociative NPS. View this paper