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Brain Sciences, Volume 14, Issue 9

September 2024 - 102 articles

Cover Story: Mitochondrial dysfunction has been implicated in various neurodegenerative disorders, including Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis, and Huntington’s diseases. Understanding the impact of mitochondrial biology on these conditions can provide valuable insights for developing targeted cell therapies. This mini-review refocuses on the mitochondria and emphasizes the potential of therapies leveraging mesenchymal stem cells, embryonic stem cells, induced pluripotent stem cells, stem cell-derived secretions, and extracellular vesicles. Mesenchymal stem cell-mediated mitochondrial transfer is highlighted for the restoration of mitochondrial health in cells with dysfunctional mitochondria. Additionally, attention is paid to gene-editing techniques such as mito-CRISPR, mitoTALENs, mito-ZNFs, and DdCBEs to ensure the safety and efficacy of stem cell treatments. View this paper
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Articles (102)

  • Review
  • Open Access
9 Citations
3,994 Views
17 Pages

The Kynurenine Pathway, Aryl Hydrocarbon Receptor, and Alzheimer’s Disease

  • Enoc Mariano Cortés Malagón,
  • Adolfo López Ornelas,
  • Irlanda Olvera Gómez and
  • José Bonilla Delgado

23 September 2024

Alzheimer’s disease (AD) is the leading cause of dementia, mainly affecting elderly individuals. AD is characterized by β-amyloid plaques, abnormal tau tangles, neuronal loss, and metabolic disruptions. Recent studies have revealed the inv...

  • Article
  • Open Access
3 Citations
5,427 Views
18 Pages

Repetitive Transcranial Magnetic Stimulation for the Treatment of Depression in a Real-World Setting: Findings from a Cohort Study

  • Tiziano Prodi,
  • Gabriele Pezzullo,
  • Kevin La Monica,
  • Alberto Priori,
  • Matteo Vismara,
  • Bernardo Dell’Osso and
  • Beatrice Benatti

22 September 2024

Background/Objectives: In the past two decades, significant advancements in neuromodulation techniques have occurred, such as transcranial magnetic stimulation (TMS) for treatment-resistant depression (TRD). According to the assumption that repeated...

  • Review
  • Open Access
11 Citations
4,743 Views
30 Pages

Calcitonin Gene-Related Peptide Monoclonal Antibodies: Key Lessons from Real-World Evidence

  • Bianca Orlando,
  • Gabriella Egeo,
  • Cinzia Aurilia,
  • Giulia Fiorentini and
  • Piero Barbanti

22 September 2024

Background: The advent of monoclonal antibodies (mAbs) targeting the calcitonin gene-related peptide (CGRP) pathway has transformed the management of migraine, offering newfound optimism for clinicians and individuals with episodic migraine (EM) and...

  • Review
  • Open Access
2 Citations
5,060 Views
14 Pages

22 September 2024

Background: Musculoskeletal pain is a leading cause of medical visits, posing significant challenges both socially and economically, encouraging the scientific community to continue researching and exploring the most effective methods to address the...

  • Article
  • Open Access
6 Citations
2,691 Views
18 Pages

Lenition in L2 Spanish: The Impact of Study Abroad on Phonological Acquisition

  • Ratree Wayland,
  • Rachel Meyer,
  • Sophia Vellozzi and
  • Kevin Tang

21 September 2024

Objective: This study investigated the degrees of lenition, or consonantal weakening, in the production of Spanish stop consonants by native English speakers during a study abroad (SA) program. Lenition is a key phonological process in Spanish, where...

  • Article
  • Open Access
4 Citations
4,779 Views
14 Pages

21 September 2024

Background: Transcutaneous auricular vagus nerve stimulation (taVNS) is effective in regulating mood and high-level cognition in patients with major depressive disorder (MDD). This study aimed to investigate the efficacy of taVNS treatment in patient...

  • Article
  • Open Access
1,138 Views
12 Pages

Neuronal Mechanisms of Reading Informational Texts in People with Different Levels of Mental Resilience

  • Małgorzata Chojak,
  • Anna Gawron,
  • Marta Czechowska-Bieluga,
  • Andrzej Różański,
  • Ewa Sarzyńska-Mazurek and
  • Anna Stachyra-Sokulska

21 September 2024

The aim of this study was to verify whether the level of mental resilience would differentiate reading comprehension performance when using different information carriers. More than 150 people filled out a test regarding the level of resilience. They...

  • Article
  • Open Access
2,527 Views
18 Pages

21 September 2024

Objectives: The main purpose of the current study was to examine the effects of social information processing, self-regulation, and metacognition variables on ToM using path analysis. Methods: For this purpose, path analysis was conducted for the mod...

  • Review
  • Open Access
7,639 Views
29 Pages

Biostasis: A Roadmap for Research in Preservation and Potential Revival of Humans

  • Andrew T. McKenzie,
  • Brian Wowk,
  • Anton Arkhipov,
  • Borys Wróbel,
  • Nathan Cheng and
  • Emil F. Kendziorra

21 September 2024

Human biostasis, the preservation of a human when all other contemporary options for extension of quality life are exhausted, offers the speculative potential for survival via continuation of life in the future. While provably reversible preservation...

  • Article
  • Open Access
4 Citations
4,395 Views
14 Pages

Effectiveness of Two Models of Telerehabilitation in Improving Recovery from Subacute Upper Limb Disability after Stroke: Robotic vs. Non-Robotic

  • Arianna Pavan,
  • Alessio Fasano,
  • Stefania Lattanzi,
  • Laura Cortellini,
  • Valeria Cipollini,
  • Sabina Insalaco,
  • Maria Cristina Mauro,
  • Marco Germanotta and
  • Irene Giovanna Aprile

21 September 2024

Background/Objectives: Finding innovative digital solutions is fundamental to ensure prompt and continuous care for patients with chronic neurological disorders, whose demand for rehabilitation also in home-based settings is steadily increasing. The...

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Brain Sci. - ISSN 2076-3425Creative Common CC BY license