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Brain Sciences, Volume 11, Issue 3

March 2021 - 128 articles

Cover Story: Stroke induces a loss in neurovascular coupling and an increase in reactive astrogliosis while producing abnormal conditions of excitability and plasticity in brain regions surrounding the infarct, which underlies the lasting disabilities observed in stroke patients. Drugs that block tonic GABA signalling promote neuronal excitability, enhance LTP formation, and lead to long-lasting enhancements in learning. Herein, GABAc receptors, which are found on astrocytes, were assessed as novel pharmacological targets for stroke recovery. Dampening GABAc receptor-mediated GABA signalling in astrocytes results in dampened reactive astrogliosis, improved astrocytic GABA uptake, and a lasting improvement in functional recovery. Image created using BioRender.com. View this paper.
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Articles (128)

  • Review
  • Open Access
6 Citations
4,975 Views
12 Pages

An ALE Meta-Analysis on Investment Decision-Making

  • Elena Ortiz-Teran,
  • Ibai Diez and
  • Joaquin Lopez-Pascual

It is claimed that investment decision-making should rely on rational analyses based on facts and not emotions. However, trying to make money out of market forecasts can trigger all types of emotional responses. As the question on how investors decid...

  • Systematic Review
  • Open Access
30 Citations
8,028 Views
22 Pages

A Scientometric Approach to Review the Role of the Medial Preoptic Area (MPOA) in Parental Behavior

  • Alessandro Carollo,
  • Jan Paolo Macapinlac Balagtas,
  • Michelle Jin-Yee Neoh and
  • Gianluca Esposito

Research investigating the neural substrates underpinning parental behaviour has recently gained momentum. Particularly, the hypothalamic medial preoptic area (MPOA) has been identified as a crucial region for parenting. The current study conducted a...

  • Review
  • Open Access
12 Citations
6,659 Views
28 Pages

Processing of Degraded Speech in Brain Disorders

  • Jessica Jiang,
  • Elia Benhamou,
  • Sheena Waters,
  • Jeremy C. S. Johnson,
  • Anna Volkmer,
  • Rimona S. Weil,
  • Charles R. Marshall,
  • Jason D. Warren and
  • Chris J. D. Hardy

The speech we hear every day is typically “degraded” by competing sounds and the idiosyncratic vocal characteristics of individual speakers. While the comprehension of “degraded” speech is normally automatic, it depends on dynamic and adaptive proces...

  • Article
  • Open Access
11 Citations
3,370 Views
13 Pages

Influence of Brain-Derived Neurotrophic Factor Genotype on Short-Latency Afferent Inhibition and Motor Cortex Metabolites

  • Ryoki Sasaki,
  • Naofumi Otsuru,
  • Shota Miyaguchi,
  • Sho Kojima,
  • Hiraku Watanabe,
  • Ken Ohno,
  • Noriko Sakurai,
  • Naoki Kodama,
  • Daisuke Sato and
  • Hideaki Onishi

The Met allele of the brain-derived neurotrophic factor (BDNF) gene confers reduced cortical BDNF expression and associated neurobehavioral changes. BDNF signaling influences the survival, development, and synaptic function of cortical networks. Here...

  • Article
  • Open Access
8 Citations
4,205 Views
11 Pages

Association between Previous Statin Use and Alzheimer’s Disease: A Nested Case-Control Study Using a National Health Screening Cohort

  • Ji Hee Kim,
  • Heui Seung Lee,
  • Jee Hye Wee,
  • Yoo Hwan Kim,
  • Chan Yang Min,
  • Dae Myoung Yoo and
  • Hyo Geun Choi

A number of studies report the incidence of Alzheimer’s disease (AD) in patients taking statins, but the results are inconsistent. (1) Background: The present study investigated the cross-sectional association between previous statin use and the risk...

  • Article
  • Open Access
7 Citations
4,575 Views
10 Pages

Mirror neuron network (MNN) is associated with one’s ability to recognize and interpret others’ actions and emotions and has a crucial role in cognition, perception, and social interaction. MNN connectivity and its relation to social attributes, such...

  • Article
  • Open Access
3 Citations
3,088 Views
12 Pages

Cortical Plasticity and Interneuron Recruitment in Adolescents Born to Women with Gestational Diabetes Mellitus

  • Jago M. Van Dam,
  • Mitchell R. Goldsworthy,
  • William M. Hague,
  • Suzette Coat and
  • Julia B. Pitcher

Exposure to gestational diabetes mellitus (GDM) in utero is associated with a range of adverse cognitive and neurological outcomes. Previously, we reported altered neuroplastic responses to continuous theta burst stimulation (cTBS) in GDM-exposed ado...

  • Article
  • Open Access
6 Citations
3,681 Views
10 Pages

Neurocognitive Impairment in Severe Mental Illness. Comparative study with Spanish Speaking Patients

  • Gabriel G. De la Torre,
  • Sandra Doval,
  • David López-Sanz,
  • Manuel García-Sedeño,
  • Miguel A. Ramallo,
  • Macarena Bernal and
  • Sara González-Torre

Background. Serious mental illness (SMI) represents a category of psychiatric disorders characterized by specific difficulties of personal and social functioning, derived from suffering severe and persistent mental health problems. Aims. We wanted to...

  • Brief Report
  • Open Access
3 Citations
3,437 Views
7 Pages

Autism is a neurodevelopmental condition associated with increased levels of anxiety. However, whether autism is related to heightened test anxiety as one situation-specific type of anxiety has not yet been examined. This question may be relevant for...

  • Article
  • Open Access
12 Citations
3,165 Views
20 Pages

Single-Nucleotide Polymorphisms in Oxidative Stress-Related Genes and the Risk of a Stroke in a Polish Population—A Preliminary Study

  • Ewelina Synowiec,
  • Paulina Wigner,
  • Natalia Cichon,
  • Cezary Watala,
  • Piotr Czarny,
  • Joanna Saluk-Bijak,
  • Elzbieta Miller,
  • Tomasz Sliwinski,
  • Ewa Zielinska-Nowak and
  • Michal Bijak

The present preliminary case-control study was undertaken to detect the potential association of six single nucleotide polymorphisms (SNPs) in oxidative stress-related genes: SOD2 (c.47T > C; rs4880), CAT (c.-89A > T; rs7943316), GPX4 (c.660T &...

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Brain Sci. - ISSN 2076-3425