You are currently viewing a new version of our website. To view the old version click .

Brain Sciences, Volume 11, Issue 4

April 2021 - 115 articles

  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.
Cover Story: The increased use of multivariate analysis approaches using positron emission tomography (PET) imaging has allowed the investigation of brain molecular processes underlying neural circuit functional interactions. The accumulation of misfolded proteins can cause a cascade of related pathological events, starting at the microscopic level and ultimately affecting the macroscopic scale level, leading to neuronal network failure. PET metabolic and neurotransmission connectome can reveal these brain region interactions in normality and disease. This review is an overview of concepts and methods of PET molecular and metabolic connectivity based on covariance assessment in neurodegenerative conditions, including Alzheimer’s disease and the Lewy Body disease spectrum. View this paper

Articles (115)

  • Article
  • Open Access
1 Citations
3,220 Views
12 Pages

Investigating human consciousness based on brain activity alone is a key challenge in cognitive neuroscience. One of its central facets, the ability to form autobiographical memories, has been investigated through several fMRI studies that have revea...

  • Review
  • Open Access
70 Citations
8,505 Views
15 Pages

Rodent models of brain disorders including neurodevelopmental, neuropsychiatric, and neurodegenerative diseases are essential for increasing our understanding of underlying pathology and for preclinical testing of potential treatments. Some of the mo...

  • Article
  • Open Access
14 Citations
3,944 Views
12 Pages

This research seeks to explore the impact of COVID-19 on depressive symptoms, analyzing discrepancies of sexual orientation in a Portuguese-speaking sample. 1590 individuals participated, of which 63% were women, and 88% self-identified as straight....

  • Article
  • Open Access
13 Citations
3,169 Views
11 Pages

Patisiran in hATTR Amyloidosis: Six-Month Latency Period before Efficacy

  • Luca Gentile,
  • Massimo Russo,
  • Marco Luigetti,
  • Giulia Bisogni,
  • Andrea Di Paolantonio,
  • Angela Romano,
  • Valeria Guglielmino,
  • Ilenia Arimatea,
  • Mario Sabatelli and
  • Antonio Toscano
  • + 2 authors

Hereditary amyloidosis associated with mutations in the transthyretin gene (hATTR) is a progressive devastating disease, with a fatal outcome occurring within 10years after onset. In recent years, TTR gene silencing therapy appeared as a promising th...

  • Article
  • Open Access
10 Citations
3,417 Views
13 Pages

EEG—Single-Channel Envelope Synchronisation and Classification for Seizure Detection and Prediction

  • James Brian Romaine,
  • Mario Pereira Martín,
  • José Ramón Salvador Ortiz and
  • José María Manzano Crespo

This paper tackles the complex issue of detecting and classifying epileptic seizures whilst maintaining the total calculations at a minimum. Where many systems depend on the coupling between multiple sources, leading to hundreds of combinations of el...

  • Systematic Review
  • Open Access
20 Citations
5,203 Views
15 Pages

Vibrotactile-Based Rehabilitation on Balance and Gait in Patients with Neurological Diseases: A Systematic Review and Metanalysis

  • Sara De Angelis,
  • Alessandro Antonio Princi,
  • Fulvio Dal Farra,
  • Giovanni Morone,
  • Carlo Caltagirone and
  • Marco Tramontano

Postural instability and fear of falling represent two major causes of decreased mobility and quality of life in cerebrovascular and neurologic diseases. In recent years, rehabilitation strategies were carried out considering a combined sensorimotor...

  • Article
  • Open Access
5 Citations
7,242 Views
17 Pages

Microsurgical Anatomy of the Anterior Circulation of the Brain Adjusted to the Neurosurgeon’s Daily Practice

  • Tomas Poblete,
  • Daniel Casanova,
  • Miguel Soto,
  • Alvaro Campero and
  • Jorge Mura

The study of cerebrovascular anatomy can be difficult and may take time due to its intrinsic complexity. However, it can also be difficult for the following reasons: the excessive description of neuroanatomy making articles hard to read, the unclear...

  • Communication
  • Open Access
18 Citations
3,880 Views
10 Pages

Morphological and Hemodynamic Changes during Cerebral Aneurysm Growth

  • Emily R. Nordahl,
  • Susheil Uthamaraj,
  • Kendall D. Dennis,
  • Alena Sejkorová,
  • Aleš Hejčl,
  • Jaroslav Hron,
  • Helena Švihlová,
  • Kent D. Carlson,
  • Yildirim Bora Suzen and
  • Dan Dragomir-Daescu

Computational fluid dynamics (CFD) has grown as a tool to help understand the hemodynamic properties related to the rupture of cerebral aneurysms. Few of these studies deal specifically with aneurysm growth and most only use a single time instance wi...

  • Brief Report
  • Open Access
1 Citations
4,471 Views
11 Pages

Corticospinal Excitability during a Perspective Taking Task as Measured by TMS-Induced Motor Evoked Potentials

  • Elizabeth Murray,
  • Janet Brenya,
  • Katherine Chavarria,
  • Karen J. Kelly,
  • Anjel Fierst,
  • Nathira Ahmad,
  • Caroline Anton,
  • Layla Shaffer,
  • Kairavi Kapila and
  • Logan Driever
  • + 12 authors

Only by understanding the ability to take a third-person perspective can we begin to elucidate the neural processes responsible for one’s inimitable conscious experience. The current study examined differences in hemispheric laterality during a first...

of 12

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Brain Sci. - ISSN 2076-3425Creative Common CC BY license