Next Article in Journal
Influence of Brain-Derived Neurotrophic Factor Genotype on Short-Latency Afferent Inhibition and Motor Cortex Metabolites
Previous Article in Journal
A Scientometric Approach to Review the Role of the Medial Preoptic Area (MPOA) in Parental Behavior
Review

Processing of Degraded Speech in Brain Disorders

1
Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK
2
Preventive Neurology Unit, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London EC1M 6BQ, UK
3
Division of Psychology and Language Sciences, University College London, London WC1H 0AP, UK
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Claude Alain
Brain Sci. 2021, 11(3), 394; https://doi.org/10.3390/brainsci11030394
Received: 18 February 2021 / Revised: 15 March 2021 / Accepted: 18 March 2021 / Published: 20 March 2021
The speech we hear every day is typically “degraded” by competing sounds and the idiosyncratic vocal characteristics of individual speakers. While the comprehension of “degraded” speech is normally automatic, it depends on dynamic and adaptive processing across distributed neural networks. This presents the brain with an immense computational challenge, making degraded speech processing vulnerable to a range of brain disorders. Therefore, it is likely to be a sensitive marker of neural circuit dysfunction and an index of retained neural plasticity. Considering experimental methods for studying degraded speech and factors that affect its processing in healthy individuals, we review the evidence for altered degraded speech processing in major neurodegenerative diseases, traumatic brain injury and stroke. We develop a predictive coding framework for understanding deficits of degraded speech processing in these disorders, focussing on the “language-led dementias”—the primary progressive aphasias. We conclude by considering prospects for using degraded speech as a probe of language network pathophysiology, a diagnostic tool and a target for therapeutic intervention. View Full-Text
Keywords: degraded speech processing; predictive coding; primary progressive aphasia; Alzheimer’s disease; Parkinson’s disease; perceptual learning; dementia degraded speech processing; predictive coding; primary progressive aphasia; Alzheimer’s disease; Parkinson’s disease; perceptual learning; dementia
Show Figures

Figure 1

MDPI and ACS Style

Jiang, J.; Benhamou, E.; Waters, S.; Johnson, J.C.S.; Volkmer, A.; Weil, R.S.; Marshall, C.R.; Warren, J.D.; Hardy, C.J.D. Processing of Degraded Speech in Brain Disorders. Brain Sci. 2021, 11, 394. https://doi.org/10.3390/brainsci11030394

AMA Style

Jiang J, Benhamou E, Waters S, Johnson JCS, Volkmer A, Weil RS, Marshall CR, Warren JD, Hardy CJD. Processing of Degraded Speech in Brain Disorders. Brain Sciences. 2021; 11(3):394. https://doi.org/10.3390/brainsci11030394

Chicago/Turabian Style

Jiang, Jessica, Elia Benhamou, Sheena Waters, Jeremy C.S. Johnson, Anna Volkmer, Rimona S. Weil, Charles R. Marshall, Jason D. Warren, and Chris J.D. Hardy 2021. "Processing of Degraded Speech in Brain Disorders" Brain Sciences 11, no. 3: 394. https://doi.org/10.3390/brainsci11030394

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop