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Medical Sciences, Volume 11, Issue 4

December 2023 - 15 articles

Cover Story: Acute hypoxic respiratory failure (AHRF) is a prominent feature of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The severity of gas exchange impairment correlates with a worse prognosis, and AHRF requiring mechanical ventilation is associated with substantial mortality. In SARS-CoV-2 AHRF, systemic vasculopathy with lung microthrombosis and microangiopathy further exacerbates poor gas exchange due to alveolar inflammation and oedema. While oxygen treatment is life-saving, alveolar hyperoxia may exacerbate a pre-existing lung injury. This review provides a summary of oxygen toxicity mechanisms, evaluating the consequences of alveolar hyperoxia in COVID-19 patients and proposing established and potential exploratory treatment pathways to minimise alveolar hyperoxia. View this paper
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Articles (15)

  • Case Report
  • Open Access
2 Citations
4,005 Views
9 Pages

Waldenström’s Macroglobulinemia and Cryoglobulinemic Glomerulonephritis: An Unusual Case of Monoclonal Gammopathy of Renal Significance

  • José C. De La Flor,
  • Jesús de María Sulca,
  • Pablo Rodríguez,
  • Daniel Villa,
  • Edna Sandoval,
  • Rocío Zamora,
  • Maribel Monroy-Condori,
  • Roxana Lipa,
  • Henry Perez and
  • Michael Cieza

5 December 2023

Cryoglobulins are immunoglobulins that precipitate at temperatures below 37 °C and dissolve upon reheating. They can induce small-vessel vasculitis with renal involvement. Cryoglobulinemic glomerulonephritis is a rare manifestation that occurs in...

  • Article
  • Open Access
2,806 Views
20 Pages

Bioinformatics Analysis of Global Diversity in Meningococcal Vaccine Antigens over the Past 10 Years: Vaccine Efficacy Prognosis

  • Viktoriia Yu. Savitskaya,
  • Nina G. Dolinnaya,
  • Vadim V. Strekalovskikh,
  • Elizaveta S. Peskovatskova,
  • Viktoriia G. Snyga,
  • Vadim S. Trefilov,
  • Mayya V. Monakhova and
  • Elena A. Kubareva

1 December 2023

Neisseria meningitidis (N. meningitidis) serogroup B (MenB) is the leading cause of invasive meningococcal disease worldwide. The pathogen has a wide range of virulence factors, which are potential vaccine components. Studying the genetic variability...

  • Systematic Review
  • Open Access
6 Citations
3,794 Views
14 Pages

28 November 2023

(1) Background: Acute patella dislocation (APD) is a prevalent knee injury, with rates between 5.8–77.8 per 100,000. APD often results in repeat lateral patella dislocations due to the instability of the medial patellofemoral ligament (MPFL). N...

  • Article
  • Open Access
3 Citations
3,558 Views
18 Pages

Association of Mediterranean Diet Adherence with Disease Progression Characteristics, Lifestyle Factors and Overall Survival in Gastric Cancer Patients

  • Eleni Pavlidou,
  • Sousana K. Papadopoulou,
  • Maria Tolia,
  • Maria Mentzelou,
  • Nikolaos Tsoukalas,
  • Olga Alexatou,
  • Theodora Tsiouda,
  • Gerasimos Tsourouflis,
  • Evmorfia Psara and
  • Vasileios Bikos
  • + 5 authors

15 November 2023

Background: The Mediterranean diet (MD) exerts a protective effect against cancer development and progression; however, the evaluation of its impact on gastric cancer still remains quite scarce. The present study aims to evaluate the association of M...

  • Article
  • Open Access
4 Citations
8,121 Views
19 Pages

15 November 2023

Autism spectrum disorder (ASD) is a type of neurodevelopmental disorder that has been diagnosed in an increasing number of children around the world. The existing data suggest that early diagnosis and intervention can improve ASD outcomes. The causes...

  • Case Report
  • Open Access
3,980 Views
7 Pages

Primary Orbital Myxoid Liposarcoma

  • Miguel Armando Benavides-Huerto,
  • Lourdes Páramo-Figueroa,
  • Daniel Moreno-Páramo and
  • Francisco Alejandro Lagunas-Rangel

8 November 2023

Although liposarcoma is the most prevalent soft tissue sarcoma in adults, head and neck liposarcomas are rare and account for less than 5% of all liposarcomas. The primary orbital location is even more exceptional, with fewer than 100 cases documente...

  • Systematic Review
  • Open Access
5 Citations
7,115 Views
17 Pages

Occupational Therapy Interventions in Patients with Frontotemporal Dementia: A Systematic Review

  • Pinelopi Vlotinou,
  • Anna Tsiakiri,
  • Georgia Detsaridou,
  • Alexandrina Nikova,
  • Dimitrios Tsiptsios,
  • Konstantinos Vadikolias and
  • Nikolaos Aggelousis

6 November 2023

Frontotemporal dementia (FTD) is a neurodegenerative disorder characterized by progressive impairments in behavior, executive function, and language, primarily affecting individuals under the age of 65. This disorder is associated with expressive and...

  • Review
  • Open Access
12 Citations
6,691 Views
20 Pages

Alveolar Hyperoxia and Exacerbation of Lung Injury in Critically Ill SARS-CoV-2 Pneumonia

  • Ahilanandan Dushianthan,
  • Luke Bracegirdle,
  • Rebecca Cusack,
  • Andrew F. Cumpstey,
  • Anthony D. Postle and
  • Michael P. W. Grocott

1 November 2023

Acute hypoxic respiratory failure (AHRF) is a prominent feature of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) critical illness. The severity of gas exchange impairment correlates with worse prognosis, and AHRF requiring mechanical v...

  • Article
  • Open Access
4 Citations
4,114 Views
12 Pages

Major Adverse Cardiac and Cerebrovascular Events in Geriatric Patients with Obstructive Sleep Apnea: An Inpatient Sample Analysis

  • Rupak Desai,
  • Sai Priyanka Mellacheruvu,
  • Sai Anusha Akella,
  • Adil Sarvar Mohammed,
  • Pakhal Saketha,
  • Abdul Aziz Mohammed,
  • Mushfequa Hussain,
  • Aamani Bavanasi,
  • Jyotsna Gummadi and
  • Praveena Sunkara

30 October 2023

Background: Obstructive sleep apnea (OSA) is associated with an increased risk of major cardiac and cerebrovascular events (MACCE). However, data on the burden and predictors of MACCE in geriatric patients with OSA (G-OSA) remain limited. Methods: Us...

  • Article
  • Open Access
2,584 Views
13 Pages

Epidemiological Profile of Ophir Loyola Cancer Hospital: A Snapshot of the Incidence of Solid Neoplasms in the Eastern Amazon

  • Juliana Ramos Chaves,
  • Mateus Itiro Tamazawskas Otake,
  • Diego Di Felipe Ávila Alcantara,
  • Rosilene Silva Lima,
  • Ana Paula Borges de Souza,
  • Janaina Silva da Costa Rodrigues,
  • Margareth Maria Braun Guimarães Imbiriba and
  • Rommel Mario Rodriguez Burbano

27 October 2023

Background: Solid neoplasms have a heterogeneous incidence worldwide and in Brazil. Thus, the region delimited by the Legal Amazon has a distinct epidemiological profile. In Pará, Ophir Loyola Cancer Hospital(OLCH) accounts for 71.11% of hospi...

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Med. Sci. - ISSN 2076-3271