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14 November 2026
Background: Full-thickness supraspinatus tears are commonly treated surgically, but the optimal repair construct and value of adjunctive strategies remain uncertain. Methods: We conducted a systematic review and meta-analysis reported according to PR...
14 November 2026
Background/Objectives: Healthcare waste is commonly framed in terms of material overuse, duplication, inefficient spending, and low-value care. However, less is known about how waste is understood within inpatient nursing practice, particularly from...
Background/Objectives: Informed consent remains a cornerstone in orthopaedic surgery, with important ethical and legal implications. The complexity of shoulder procedures and patient expectations require clear and accurate information. Artificial int...
Introduction and Objective: Monitoring short-term changes in functional and neuromotor performance among older adults during a two-week hospital stay remains challenging in everyday geriatric practice. In this context, the present exploratory observa...
Background/Objectives: Immune alterations in chronic heart failure (CHF) have been characterized mainly at the group level, leaving heterogeneity between patients undefined. We asked whether peripheral blood transcriptomes resolve distinct immune sta...
Objectives: Alzheimer’s disease and related dementias (ADRD) impose substantial clinical and public health burdens, while treatment options remain limited. We developed a novel mechanism-agnostic Medication-Wide Association Study (MWAS) approac...
Background/Objectives: AI-assisted documentation and coding tools add diagnoses to health records, and self-updating AI agents may soon learn from the codes they generate. The objective was to develop a framework for asking whether such systems could...
Background: Extreme temperatures, severe weather events, and air pollution pose important challenges to cardiovascular health. However, patients’ perceptions of environmental risks, symptom-related experiences, adaptive behaviours, and informat...
Background: Rapid antimicrobial susceptibility testing (AST) has been developed to shorten the interval between blood-culture positivity and the availability of actionable susceptibility results in patients with bloodstream infection (BSI). Although...
Background/Objectives: Hospitalization frequently exacerbates muscle wasting and functional decline in vulnerable older adults, yet comprehensive geriatric assessments are often too time-consuming. This study evaluated the clinical utility of baselin...
Background: Parasomnias are abnormal behaviours in sleep. Disorders that can cause microarousals, such as obstructive sleep apnoea (OSA) and periodic limb movements in sleep (PLMS) are often considered to trigger parasomnias. However, the prevalence...
Background/Objectives: Oral frailty (OFr) and gut dysbiosis have each been associated with depressive symptoms (DSs); however, their interactive effects on DSs remain unclear. This study aimed to investigate the combined association of OFr and gut mi...
Background: ICU-admission lactate after liver transplantation (LT) may reflect perioperative stress, but its association with cumulative morbidity remains unclear. Methods: This retrospective cohort included 457 adults undergoing first LT between Oct...
Cardiac Amyloidosis (CA) is often underdiagnosed and diagnosed late because its phenotype overlaps with that of hypertensive cardiovascular disease, hypertrophic cardiomyopathy (HCM), aortic stenosis and heart failure with preserved ejection fraction...
Non-muscle-invasive bladder cancer (NMIBC) requires lifelong surveillance, traditionally based on repeated cystoscopy and urine cytology, which impose substantial physical, psychological, and economic burdens. Although urinary biomarkers have been ex...
Background/Objectives: Early changes in serum creatinine after cardiac surgery reflect the interplay of baseline renal vulnerability, cardiopulmonary bypass (CPB), haemodynamic disturbances, perfusion-related factors and systemic inflammation. We exa...
Background: Surrogate indices proposed to reflect insulin resistance-related metabolic characteristics, together with anthropometric markers of central adiposity, have been associated with cardiometabolic characteristics, although their distributions...
Background/Objectives: This study evaluated whether sex-specific machine learning models using non-invasive variables could identify individuals with glucose concentrations of ≥200 mg/dL at 120 min during an oral glucose tolerance test (OGTT) and...
Background/Objectives: We compared echocardiographic indices with galectin-3 and pentraxin-3 for discriminating established heart failure (HF). Methods: This exploratory cross-sectional secondary analysis included 131 coronary angiography patients: 6...
Background: Defined by the coexistence of at least two cardiovascular diseases, type 2 diabetes and suspected metabolic dysfunction-associated steatotic liver disease, cardiovascular–liver–metabolic multimorbidity (CLMM) is an emerging ph...
Background: Comprehensive molecular profiling is increasingly important in advanced non-small cell lung cancer (NSCLC), but the integration of tissue- and plasma-based next-generation sequencing (NGS) and its real-world therapeutic impact remain unce...
Introduction/Objectives: Prolonged exposure to solar radiation triggers oxidative stress and inflammation, accelerating skin photoaging and photocarcinogenesis. This study evaluated a novel hybrid formulation acting as a biological photoprotective ad...
Background: Oral submucous fibrosis (OSMF) is a potentially malignant disorder characterized by debilitating symptoms, including a burning sensation and reduced mouth opening. Although various therapeutic options exist, no consensus exists on the mos...
Endometriosis is a chronic, estrogen-dependent disease that affects up to 10% of women of reproductive age and leads to pain, infertility, and impaired quality of life. Despite current hormonal and surgical therapies, many patients continue to suffer...
Background/Objectives: Microfracture remains the most widely used first-line procedure for focal chondral defects of the knee, but its fibrocartilaginous repair deteriorates over time. This review asked whether adding an orthobiologic or scaffold to...
Objective: To analyze the association between body composition, neurological impairment, functional capacity, quality of life, and oxidative stress biomarkers in leprosy patients from endemic reference centers. Methods: In this observational, cross-s...
Background/Objectives: Radiation-induced laryngeal radionecrosis and chondroradionecrosis (LRN/LCRN) are uncommon but potentially severe complications of radiotherapy that may lead to airway compromise, persistent functional impairment, or total lary...
Background: Host blood transcriptional signatures may help distinguish active pulmonary tuberculosis (PTB) from latent tuberculosis infection (LTBI), but their diagnostic performance and generalizability require further evaluation. This study investi...
Background/Objectives: The single breath count (SBC) and breath holding time (BHT) are increasingly used as dysfunctional breathing (DB) outcome measures; yet, their properties derive from populations in which they act as surrogates of vital capacity...
Background/Objectives: Colorectal cancer (CRC) is among the most common cancers in women in the United Arab Emirates (UAE), but women-specific data on CRC awareness and knowledge in the country are scarce. We examined awareness of CRC, knowledge of i...
Small intestine transplantation is a complex operation used for conditions such as short bowel syndrome, Crohn’s disease, intestinal motility disorders, birth defects, and tumors. This work analyzes the morphological and physiological changes t...
Background: Knee osteoarthritis is a highly prevalent degenerative condition, characterized by chronic pain, joint stiffness, and functional limitation, with a significant impact on quality of life. Conventional therapies have limited efficacy, espec...
Radiotherapy represents an effective treatment for different cancer types and is continuously evolving through the development of more accurate therapeutic approaches, although radioresistance and treatment failure still remain important challenges....
Background/Objectives: Risk stratification and prognostic prediction are embedded in revascularization practice for acute coronary syndromes, but the longitudinal evolution and scientific architecture of this literature remain poorly characterized. W...
Background/Objectives: Current data on documented fertility-related diagnoses in German outpatient gynecological care are scarce. This study described their frequency and trends between 2021 and 2025. Methods: This retrospective cross-sectional study...
Background: Portal vein resection (PVR) extends curative-intent surgery for locally advanced perihilar cholangiocarcinoma (pCCA). However, whether PVR independently affects perioperative and long-term outcomes remains unclear. This study evaluated th...
Background: Perioperative management of antiplatelet therapy in colorectal surgery requires balancing the risk of surgical bleeding against cardiovascular and cerebrovascular complications after treatment withdrawal. This meta-analysis assessed the s...
Background: We aimed to examine sex-related differences in the allocation of intensive care and mechanical ventilation among patients with myocardial infarction. Understanding these differences may help identify potential disparities in critical care...
Background/Objectives: Obesity is a well-established risk factor for severe COVID-19, largely mediated by chronic inflammation originating from adipose tissue. The role of para-aortic adipose tissue (PAT)—a component of perivascular adipose tis...
Background/Objectives: Psychosocial difficulties during the menopausal transition, including impaired self-esteem, perceived isolation, and perceived need for support, remain insufficiently characterized in Eastern European populations. This study es...
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Background: Metastatic-site frequencies reflect both how extensively a cancer spreads and how commonly an organ is involved across cancers. We assessed whether cancer–organ affinity beyond these overall effects is reproducible between autopsy a...
Background: Performance estimates in medical-imaging artificial intelligence may depend not only on model architecture but also on dataset integrity, label reproducibility, and the complexity of the prediction target. This study evaluated deep learni...
Background: ECMO is used in patients with refractory cardiopulmonary failure when conventional therapy fails; however, biomarker features associated with this clinical deterioration remain unclear. We investigated whether dynamic biomarker changes we...
Additional Acknowledgments [...]
Background/Objectives: Adolescent nicotine use increasingly extends beyond cigarettes to e-cigarettes, heated tobacco products and oral nicotine. This study aimed to characterize nicotine-product use, knowledge, risk perceptions and associated factor...
Background/Objectives: Up to 40% of patients receiving cardiac resynchronization therapy (CRT) do not experience significant clinical improvement, highlighting the limitations of conventional selection criteria. Artificial intelligence (AI) is increa...
Introduction: Surgical procedures for ophthalmic-segment aneurysms require multiple estimations of postoperative visual risk, successful treatment outcomes, and surgical demands. The authors created a model called OphA-PRISM to determine the risks as...
Background: The growing interest in artificial intelligence (AI) in cardiothoracic surgery has led to a substantial increase in scientific publications, although its integration into routine clinical practice remains limited. Despite encouraging deve...
Frailty is a dynamic state of reduced reserve whose expression reflects clinical, functional, cognitive, psychological, social, and environmental factors. This structured narrative review examines its conceptual models, determinants, consequences, mu...
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