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Microorganisms, Volume 13, Issue 4

April 2025 - 257 articles

Cover Story: This comprehensive review examines the pressing global health challenge of multidrug-resistant tuberculosis (MDR-TB) and explores cutting-edge strategies to overcome treatment limitations. The authors delve into the molecular basis of drug resistance in Mycobacterium tuberculosis while highlighting promising advances in nanomedicine, targeted drug delivery systems, and host-directed therapies. The review emphasizes the critical importance of multidisciplinary approaches that combine novel drug discovery, advanced delivery systems, and immunomodulation to address the complexities of MDR-TB treatment. With its focus on personalized medicine and innovative therapeutic strategies, this timely analysis provides valuable insights for researchers, clinicians, and policymakers working to develop effective, accessible, and affordable treatments for this persistent public health threat. View this paper
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Articles (257)

  • Article
  • Open Access
1,362 Views
15 Pages

Gardnerella vaginalis (GV), an opportunistic pathogen excessively proliferated in vaginal dysbiosis, causes systemic inflammation including vaginitis, neuroinflammation, and osteitis. To understand its systemic inflammation-triggering factor, we puri...

  • Article
  • Open Access
1 Citations
1,332 Views
16 Pages

Escherichia coli is a significant pathogen capable of inducing a variety of infections in both human and animal hosts. Despite its clinical significance, there is a lack of longitudinal research aimed at elucidating the genomic attributes that facili...

  • Article
  • Open Access
3 Citations
1,631 Views
19 Pages

Xanthomonas oryzae pv. oryzae (Xoo) is a biotrophic bacterial pathogen, which causes devastating bacterial blight disease worldwide. In this study, we thoroughly investigated the antimicrobial effect of the plant-derived extract chelerythrine against...

  • Review
  • Open Access
28 Citations
7,128 Views
18 Pages

Silver Nanoparticles and Antibiotics: A Promising Synergistic Approach to Multidrug-Resistant Infections

  • Eudald Casals,
  • Muriel F. Gusta,
  • Neus Bastus,
  • Jordi Rello and
  • Victor Puntes

The escalating threat of antibiotic resistance demands innovative strategies against multidrug-resistant (MDR) microorganisms, particularly in hospital settings where such infections represent a major global health challenge. Since the rapid growth o...

  • Review
  • Open Access
4 Citations
4,967 Views
24 Pages

Environmental Risk Factors Contributing to the Spread of Antibiotic Resistance in West Africa

  • Adenike Adenaya,
  • Adedapo Adedayo Adeniran,
  • Chidera Linus Ugwuoke,
  • Kaosara Saliu,
  • Mariam Adewumi Raji,
  • Amartya Rakshit,
  • Mariana Ribas-Ribas and
  • Martin Könneke

Antibiotic resistance is a well-documented global health challenge that disproportionately impacts low- and middle-income countries. In 2019, the number of deaths attributed to and associated with antibiotic resistance in Western Sub-Saharan Africa w...

  • Systematic Review
  • Open Access
2,192 Views
23 Pages

How the Built Environment Shapes Children’s Microbiome: A Systematic Review

  • Rozalynne Samira,
  • Muntazar Monsur and
  • Nazia Afrin Trina

This systematic review aims to synthesize key empirical findings to understand how various elements of the built environment influence the microbiome concerning children’s health and well-being. A comprehensive literature search was conducted a...

  • Article
  • Open Access
7 Citations
2,900 Views
22 Pages

Clinical success in treating complicated urinary tract infections (cUTIs) depends on accurate pathogen detection, given the common occurrence of polymicrobial infections and antimicrobial resistance. This multicenter, randomized, investigator-blinded...

  • Review
  • Open Access
5 Citations
4,616 Views
24 Pages

The Microbiota–Human Health Axis

  • Harrie Toms John,
  • Treesa Clare Thomas,
  • Ezenwa Collins Chukwuebuka,
  • Ali Bacar Ali,
  • Reggani Anass,
  • Yididiya Yilma Tefera,
  • Bency Babu,
  • Nicoleta Negrut,
  • Anca Ferician and
  • Paula Marian

Trillions of microorganisms play a pivotal role in maintaining health and preventing disease in humans. Their presence influences daily life, habits, energy levels, and pathologies. The present narrative review synthesized recent studies of microbial...

  • Article
  • Open Access
1 Citations
1,377 Views
22 Pages

Microbiome Migration from Soil to Leaves in Maize and Rice

  • Jiejia Ma,
  • Qianze Peng,
  • Silu Chen,
  • Zhuoxin Liu,
  • Weixing Zhang,
  • Chi Zhang,
  • Xiaohua Du,
  • Shue Sun,
  • Weiye Peng and
  • Ziling Lei
  • + 4 authors

The interactions between plants and microbes are essential for enhancing crop productivity. However, the mechanisms underlying host-specific microbiome migration and functional assembly remain poorly understood. In this study, microbiome migration fr...

  • Article
  • Open Access
3 Citations
872 Views
12 Pages

New Findings on the Survival of Durusdinium glynnii Under Different Acclimation Methods to Low Salinities

  • Barbara de Cassia S. Brandão,
  • Jéssika L. de Abreu,
  • Deyvid Willame S. Oliveira,
  • Clarissa Vilela F. da Silva Campos,
  • Ingrid M. Thó de Aguiar,
  • Pedro R. de Sena,
  • Alfredo O. Gálvez and
  • Carlos Yure B. Oliveira

This study investigated the effects of salinity on the growth and cell morphotype of the coral-associated dinoflagellate Durusdinium glynnii under two acclimation strategies: abrupt saline shock (S5) and gradual reduction (S2). Results revealed optim...

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Microorganisms - ISSN 2076-2607