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Pathogens, Volume 9, Issue 1 (January 2020) – 70 articles
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Cover Story (view full-size image) Streptococcus suis is commonly found in pigs colonizing the mucosa without induction of clinical [...] Read more. Streptococcus suis is commonly found in pigs colonizing the mucosa without induction of clinical signs. However, invasive infection in piglets can lead to severe disease associated with septicemia, meningitis or arthritis. The effects of S. suis on cytokine induction have been demonstrated previously in porcine, murine and human in vitro models, but in vivo data from pigs were missing. This study investigated the S. suis-induced cytokine response in experimentally infected weaning piglets and compared the in vivo data with an in vitro cytokine analysis using porcine whole blood and PBMC. Specifically, induction of TNF-α, IL‑6, and IL‑10 and their regulation was analyzed. The presented results confirm the relevance of in vitro models for S. suis-associated bacteremia and point to interactions between pro- and anti-inflammatory cytokines. View this paper