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Pathogens, Volume 9, Issue 1

January 2020 - 70 articles

Cover Story: Streptococcus suis is commonly found in pigs colonizing the mucosa without induction of clinical signs. However, invasive infection in piglets can lead to severe disease associated with septicemia, meningitis or arthritis. The effects of S. suis on cytokine induction have been demonstrated previously in porcine, murine and human in vitro models, but in vivo data from pigs were missing. This study investigated the S. suis-induced cytokine response in experimentally infected weaning piglets and compared the in vivo data with an in vitro cytokine analysis using porcine whole blood and PBMC. Specifically, induction of TNF-α, IL‑6, and IL‑10 and their regulation was analyzed. The presented results confirm the relevance of in vitro models for S. suis-associated bacteremia and point to interactions between pro- and anti-inflammatory cytokines. View this paper
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Articles (70)

  • Article
  • Open Access
39 Citations
10,502 Views
23 Pages

Characterization of Pathogenic and Nonpathogenic Fusarium oxysporum Isolates Associated with Commercial Tomato Crops in the Andean Region of Colombia

  • Sandra L. Carmona,
  • Diana Burbano-David,
  • Magda R. Gómez,
  • Walter Lopez,
  • Nelson Ceballos,
  • Jairo Castaño-Zapata,
  • Jaime Simbaqueba and
  • Mauricio Soto-Suárez

20 January 2020

In Colombia, tomato production under protected conditions represents an important economic contribution to the agricultural sector. Fusarium wilt diseases, caused by pathogenic formae speciales of the soil-borne fungus Fusarium oxysporum Schltdl., ca...

  • Article
  • Open Access
8 Citations
3,440 Views
11 Pages

Differences in Epstein-Barr Virus Characteristics and Viral-Related Microenvironment Could Be Responsible for Lymphomagenesis in Children

  • Aldana Vistarop,
  • Oscar Jimenez,
  • Melina Cohen,
  • Elena De Matteo,
  • Maria Victoria Preciado and
  • Paola Chabay

19 January 2020

In Argentina, Epstein-Barr virus (EBV) presence is associated with Hodgkin lymphoma (HL) in patients younger than 10 years, suggesting a relationship between low age of EBV infection and HL. Given that HL is derived from germinal centers (GC), our ai...

  • Article
  • Open Access
10 Citations
9,754 Views
14 Pages

Staphylococcus saprophyticus Proteomic Analyses Elucidate Differences in the Protein Repertories among Clinical Strains Related to Virulence and Persistence

  • Karla Christina Sousa Silva,
  • Lana O’Hara Souza Silva,
  • Guilherme Algusto Alves Silva,
  • Clayton Luiz Borges,
  • Evandro Novaes,
  • Juliano Domiraci Paccez,
  • Wagner Fontes,
  • Marcia Giambiagi-deMarval,
  • Célia Maria de Almeida Soares and
  • Juliana Alves Parente-Rocha

19 January 2020

Staphylococcus saprophyticus is a Gram-positive and coagulase negative cocci that composes the skin microbiota and can act as an opportunistic agent causing urinary tract infections, being more frequent in sexually active young women. The ability of...

  • Article
  • Open Access
18 Citations
5,882 Views
12 Pages

In Vivo Antiviral Effects of U18666A Against Type I Feline Infectious Peritonitis Virus

  • Tomoyoshi Doki,
  • Tomoyo Tarusawa,
  • Tsutomu Hohdatsu and
  • Tomomi Takano

18 January 2020

Background: The cationic amphiphilic drug U18666A inhibits the proliferation of type I FIPV in vitro. In this study, we evaluated the in vivo antiviral effects of U18666A by administering it to SPF cats challenged with type I FIPV. Methods: Ten SPF c...

  • Article
  • Open Access
15 Citations
5,569 Views
12 Pages

16 January 2020

In many low- and middle-income countries, data limitations are a major challenge facing the development of food safety risk assessment. In the present study, a questionnaire data collection tool was designed with an emphasis on gathering specific dat...

  • Article
  • Open Access
9 Citations
3,671 Views
11 Pages

High-Resolution Composition Analysis of an Inactivated Polyvalent Foot-and-Mouth Disease Vaccine

  • Leonie F. Forth,
  • Dirk Höper,
  • Martin Beer and
  • Michael Eschbaumer

16 January 2020

Appropriate vaccine selection is crucial in the control of foot-and-mouth disease (FMD). Vaccination can prevent clinical disease and reduces viral shedding, but there is a lack of cross-protection between the seven serotypes and their sublineages, m...

  • Article
  • Open Access
20 Citations
4,407 Views
10 Pages

Seroprevalence and Molecular Detection of Bovine Anaplasmosis in Egypt

  • Omid Parvizi,
  • Hosny El-Adawy,
  • Falk Melzer,
  • Uwe Roesler,
  • Heinrich Neubauer and
  • Katja Mertens-Scholz

16 January 2020

Bovine anaplasmosis is a tick-borne disease with zoonotic potential, caused by the obligate intracellular bacterium Anaplasma marginale. The disease is distributed worldwide in tropical and subtropical regions. The economic losses from anaplasmosis i...

  • Article
  • Open Access
22 Citations
4,778 Views
14 Pages

High Prevalence of CTX-M Type Extended-Spectrum Beta-Lactamase Genes and Detection of NDM-1 Carbapenemase Gene in Extraintestinal Pathogenic Escherichia coli in Cuba

  • Dianelys Quiñones,
  • Meiji Soe Aung,
  • Yenisel Carmona,
  • María Karla González,
  • Niurka Pereda,
  • Mercedes Hidalgo,
  • Mayrelis Rivero,
  • Arnaldo Zayas,
  • Rosa del Campo and
  • Noriko Urushibara
  • + 1 author

16 January 2020

Increase of extraintestinal pathogenic Escherichia coli (ExPEC) showing resistance to beta-lactams is a major public health concern. This study was conducted as a first molecular epidemiological study on ExPEC in Cuba, regarding prevalence of extende...

  • Article
  • Open Access
29 Citations
5,493 Views
16 Pages

16 January 2020

The use of organic components from plants as an alternative antimicrobial agent is becoming popular due to the development of drug-resistance in various pathogens. Essential oils from fresh (MF-1) and dried (MD-1) roots of Salvadora persica L. were e...

  • Article
  • Open Access
9 Citations
3,346 Views
12 Pages

15 January 2020

From 2010, novel recombinant lineage 3 of porcine reproductive and respiratory syndrome virus 2 (PRRSV2) has continuously emerged China, which has brought about clinical outbreaks of the disease. Previously, a PRRSV2 strain named ZJnb16-2 was identif...

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Pathogens - ISSN 2076-0817