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Pathogens, Volume 14, Issue 7

July 2025 - 113 articles

Cover Story: The present study utilizes herpes simplex virus type 1 (HSV-1), a rare but serious respiratory infection that causes pneumonia in the elderly, to demonstrate that aging exacerbates lung infection and disease in mice. Compared to young and adult mice, aged mice exhibited (i) impaired expression of TLR3, a marker that plays a crucial role in antiviral response, on airway epithelial cells, dendritic cells, and macrophages; (ii) decreased frequencies of activated dendritic cells expressing MHC-I, MHC-II, and CD80/86; (iii) decreased frequencies of antiviral CD4+ and CD8+ T cells expressing cytotoxic markers (GzmB and CD107) and producing IFN-γ; and (iv) reduced anti-inflammatory cytokines in the lungs. These findings highlight an age-associated decline of innate and adaptive immune responses to respiratory viral infections. View this paper
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Articles (113)

  • Article
  • Open Access
1 Citations
1,265 Views
12 Pages

Detection and Molecular Characterization of Rift Valley Fever Virus in Apparently Healthy Cattle in Uganda

  • Eugene Arinaitwe,
  • Kaitlyn Waters,
  • Bonto Faburay,
  • Gladys K. Nakanjako,
  • David Kalenzi Atuhaire,
  • Mathias Afayoa,
  • Frank Norbert Mwiine and
  • Joseph Erume

Rift Valley fever (RVF) is a zoonotic disease caused by the Rift Valley fever virus (RVFV), affecting humans, livestock, and wild ruminants. This study aimed to characterize and assess the genetic diversity of RVFV strains circulating among livestock...

  • Article
  • Open Access
1 Citations
827 Views
11 Pages

A Look Under the Carpet of a Successful Eradication Campaign Against Small Ruminant Lentiviruses

  • Fadri Vincenz,
  • Maksym Samoilenko,
  • Carlos Eduardo Abril,
  • Patrik Zanolari,
  • Giuseppe Bertoni and
  • Beat Thomann

Small ruminant lentiviruses (SRLVs) are widespread and have a long co-evolutionary history with their hosts, namely sheep and goats. These viruses induce insidious pathologies, causing significant financial losses and animal welfare issues for the af...

  • Article
  • Open Access
1 Citations
1,082 Views
18 Pages

Vector-Borne Agents in Species of Silky Anteater (Cyclopes Gray, 1821) from South America

  • Pedro Henrique Cotrin Rodrigues,
  • João Paulo Soares Alves,
  • Flávia Regina Miranda,
  • Cesar Rojano and
  • Júlia Angélica Gonçalves Silveira

Cyclopes, the smallest of all known anteaters, has an insectivorous diet and is arboreal, rarely descending to the ground. There are scarce reports on diseases and pathogenic agents affecting this taxon. Hemopathogens are pathogenic agents that inhab...

  • Systematic Review
  • Open Access
2 Citations
6,784 Views
17 Pages

Efficacy of GS-441524 for Feline Infectious Peritonitis: A Systematic Review (2018–2024)

  • Emma Gokalsing,
  • Joana Ferrolho,
  • Mark S. Gibson,
  • Hugo Vilhena and
  • Sofia Anastácio

Feline infectious peritonitis (FIP) is a severe viral disease with a very high fatality rate. GS-441524 is an adenosine analogue that acts as an antiviral and has shown promise in FIP treatment. However, its commercialization in some regions is not y...

  • Article
  • Open Access
971 Views
27 Pages

Distinct Virologic Properties of African and Epidemic Zika Virus Strains: The Role of the Envelope Protein in Viral Entry, Immune Activation, and Neuropathogenesis

  • Ashkan Roozitalab,
  • Chenyu Zhang,
  • Jiantao Zhang,
  • Ge Li,
  • Chengyu Yang,
  • Wangheng Hou,
  • Qiyi Tang and
  • Richard Y. Zhao

The 2016 Zika virus (ZIKV) epidemic has largely subsided, but a key question remains. How did ZIKV evolve to become a virulent human pathogen compared to the virus of its original discovery? What specific virologic and pathologic changes contributed...

  • Article
  • Open Access
1,366 Views
12 Pages

Coinfections with hepatitis C virus (HCV) or human immunodeficiency virus (HIV) among individuals with chronic hepatitis B (CHB) are associated with worse clinical outcomes but remain understudied due to their low prevalence and the sensitivity of as...

  • Article
  • Open Access
1,060 Views
17 Pages

A Novel Parvovirus Associated with the Whitefly Bemisia tabaci

  • Fani Gousi,
  • Zineb Belabess,
  • Nathalie Laboureau,
  • Michel Peterschmitt and
  • Mikhail M. Pooggin

The whitefly Bemisia tabaci (Hemiptera: Aleyrodoidea) causes direct feeding damage to crop plants and transmits pathogenic plant viruses, thereby threatening global food security. Although whitefly-infecting RNA viruses are known and proposed as bioc...

  • Article
  • Open Access
1,102 Views
15 Pages

Expanding the Antiviral Spectrum of Scorpion-Derived Peptides Against Toscana Virus and Schmallenberg Virus

  • Rosa Giugliano,
  • Carla Zannella,
  • Roberta Della Marca,
  • Annalisa Chianese,
  • Laura Di Clemente,
  • Alessandra Monti,
  • Nunzianna Doti,
  • Federica Cacioppo,
  • Valentina Iovane and
  • Serena Montagnaro
  • + 3 authors

Toscana virus (TOSV) and Schmallenberg virus (SBV) are arthropod-borne viruses from the Bunyaviricetes class, posing significant human and animal health threats. TOSV, endemic to the Mediterranean region, is a notable human pathogen detected in vario...

  • Article
  • Open Access
1 Citations
902 Views
16 Pages

Surveillance of Salmonella Serovars in the Food Chain in Poland: A Five-Year Review (2016–2020)

  • Ewelina Skrzypiec,
  • Magdalena Skarżyńska,
  • Magdalena Zając,
  • Renata Kwit,
  • Anna Lalak,
  • Aleksandra Śmiałowska-Węglińska,
  • Emilia Mikos-Wojewoda,
  • Paulina Pasim,
  • Weronika Koza and
  • Dominika Wojdat
  • + 4 authors

(1) Background: Understanding the distribution of Salmonella serovars in food, animals, and their environments is crucial for identifying infection sources and monitoring pathogen prevalence in the food chain. This study analysed Salmonella serovars...

  • Article
  • Open Access
1,476 Views
21 Pages

Pneumococcal Infection and Vaccination-Related Knowledge, Attitudes and Practices Among Saudi Residents

  • Wed S. Althobaiti,
  • Abeer D. Alnefaie,
  • Kaifah M. Althaali,
  • Ola M. Alsufyani,
  • Yassmin M. Shebany,
  • Ayman A. Atalla,
  • Ibtihal M. Alotaibi,
  • Eman Y. Santali and
  • Sayed F. Abdelwahab

Background and aims: Pneumococcal infections, primarily caused by Streptococcus pneumoniae, pose significant global public health challenges, particularly in vulnerable populations. In Saudi Arabia, the introduction of pneumococcal vaccination has be...

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Pathogens - ISSN 2076-0817