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Pathogens, Volume 14, Issue 8

August 2025 - 114 articles

Cover Story: Effect of an anti-amyloid peptide on Candida binding and invasion of oral epithelial cells. The findings presented herein demonstrate that functional amyloids are important for the aggregation of pathogenic Candida species and adhesion to epithelial cells. Functional amyloids in surface-bound adhesins are predicted bioinformatically and confirmed experimentally. Amyloid-binding reagents stain the surface of the fungi. Anti-amyloid compounds, including a specific peptide inhibitor, prevent cell–cell binding. The inhibitory peptide also reduces the binding of Candida to oral epithelia. Consequently, the peptide also reduces fungal invasion of the epithelial cells. This publication commemorates the life of Melissa Garcia-Sherman. She designed and supervised the experiments and also took these micrographs. View this paper
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Articles (114)

  • Article
  • Open Access
963 Views
22 Pages

21 August 2025

Objective: This study aims to investigate the pharmacodynamic effects and underlying mechanisms of the Chinese herbal formula RuHaoDaShi (RHDS) granules against the influenza virus in experimental models. Methods: This study aims to employ network ph...

  • Article
  • Open Access
1 Citations
984 Views
10 Pages

Introduction and Spatial–Temporal Distribution of Oropouche Virus in Rio de Janeiro State, Brazil

  • Fábio Burack da Costa,
  • Andrea Cony Cavalcanti,
  • Rafael Santos Erbisti,
  • Vanessa Zaquieu Dias,
  • Cristiane Gomes de Castro Moreira,
  • Mateus Marques Grifo,
  • Maria Carmelita dos Santos Vaz,
  • Adriana Cardoso Camargo,
  • Leandro Magalhães de Souza and
  • Flávia Barreto dos Santos
  • + 4 authors

21 August 2025

The Oropouche virus (OROV) has been circulating in the Amazon region since the 1960s, with a progressive increase in outbreaks and human cases reported in Brazil and neighboring countries. In the Rio de Janeiro state, there has been a significant ris...

  • Review
  • Open Access
2,103 Views
19 Pages

Hansen’s Disease in Ecuador: Current Status, Knowledge Gaps, and Research Priorities: A Literature Review

  • Manuel Calvopiña,
  • Juan S. Izquierdo-Condoy,
  • Esteban Ortiz-Prado,
  • Jorge Vasconez-Gonzalez,
  • Lorena Vaca and
  • Elías Guamán

21 August 2025

Background: Hansen’s disease or leprosy is one of the 21 neglected tropical diseases (NTDs). In Ecuador, leprosy is considered eliminated as a public health problem; however, new cases are reported annually. Additionally, Mycobacterium leprae i...

  • Article
  • Open Access
837 Views
11 Pages

Susceptibility of Neisseria gonorrhoeae to Zoliflodacin and Quinolones in Hyogo Prefecture, Japan

  • Takashi Yurube,
  • Katsumi Shigemura,
  • Yurino Kobayashi,
  • Taishi Maeda,
  • Nami Nishimura,
  • Ayaka Yamada,
  • Kotoko Kotani,
  • Saki Horii,
  • Hiroyuki Yoshida and
  • Kayo Osawa

21 August 2025

The DNA synthesis inhibitor zoliflodacin (ZFD) is expected to be effective against strains resistant to therapeutic agents for Neisseria gonorrhoeae infection. In addition to ZFD, we investigated the susceptibility of N. gonorrhoeae strains to ceftri...

  • Systematic Review
  • Open Access
1,245 Views
17 Pages

21 August 2025

Background: Viral–bacterial co-infections can amplify disease severity through complex biological mechanisms. Mathematical models are critical tools for understanding these threats, but it is unclear how well they capture the underlying biology...

  • Systematic Review
  • Open Access
1,326 Views
10 Pages

Infective Endocarditis by Fusobacterium Species—A Systematic Review

  • Petros Ioannou,
  • Eleni Mourati,
  • Styliani Thalasseli Kazali,
  • Chrysoula Bali,
  • Stella Baliou and
  • George Samonis

21 August 2025

Background: Fusobacterium species are anaerobic Gram-negative bacilli that are part of the normal oropharyngeal and gastrointestinal flora. Although rare, they can cause infective endocarditis (IE), a severe condition with high morbidity. The clinica...

  • Review
  • Open Access
798 Views
16 Pages

Host Immune Response in Chronic Hepatitis Delta: Implications for Pathogenesis and Therapy

  • Arshi Khanam,
  • Abutaleb Ameer,
  • Poonam Mathur,
  • Cihan Yurdaydin and
  • Shyam Kottilil

21 August 2025

Chronic hepatitis delta (CHD) represents the most severe form of viral hepatitis due to rapid disease progression towards liver cancer, leading to high morbidity and mortality. Hepatitis delta virus (HDV) can only infect individuals who are infected...

  • Article
  • Open Access
760 Views
10 Pages

Anti-SARS-CoV-2 Antibodies in Urine of Individuals Vaccinated with Janssen AD26.COV2.S COVID-19 Vaccine

  • Marina F. N. Melo,
  • Rômulo C. D. Lira,
  • Raquel S. B. Câmara,
  • Isabela A. G. Pereira,
  • Fernanda F. Ramos,
  • Carolina S. F. Costa,
  • Laura F. Amorim,
  • Quezia D. Teixeira,
  • Flávio G. da Fonseca and
  • Vandack Nobre
  • + 5 authors

21 August 2025

Urine-based immunoassay is a non-invasive method with demonstrated utility in detecting anti-SARS-CoV-2 antibodies in unvaccinated patients with COVID-19. To evaluate urine’s potential for serological surveys in a real-world setting, SARS-CoV-2...

  • Article
  • Open Access
981 Views
18 Pages

In Vitro Investigation of the Antimicrobial Properties of Gerês Propolis in Bacteria Isolated from Companion Animals and Safety Profile Characterization Using the Galleria mellonella Model

  • Rafael Rodrigues,
  • Rui Almeida,
  • Soraia C. V. Rodrigues,
  • Joana Castro,
  • Ricardo Oliveira,
  • Nuno Mendes,
  • Carina Almeida,
  • Sónia Silva,
  • Daniela Araújo and
  • Cristina Almeida-Aguiar

21 August 2025

Propolis, also known as bee glue, is a natural resinous mixture produced by Western honeybees and has long been recognized for its potential therapeutic properties. Recent research has focused on its diverse bioactivities, particularly its antimicrob...

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Pathogens - ISSN 2076-0817Creative Common CC BY license