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Journal of Personalized Medicine, Volume 14, Issue 2

February 2024 - 93 articles

Cover Story: Biological sex is one of the major factors characterizing the heart failure (HF) phenotype. There are sex differences in left ventricular (LV) remodeling patterns in an HF setting, namely, concentric remodeling and diastolic dysfunction in females and eccentric remodeling and systolic dysfunction in males. Recently supra-normal EF has been recognized as a risk of a worse outcome. This pathology might be more relevant in females. Estrogen deficit might play a significant role in this pathophysiology, possible through coronary microvascular dysfunction and sympathetic nerve overactivation. The lack of implementation of guideline-directed medical therapy for females with HF with reduced EF might also contribute to these sex differences. View this paper
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Articles (93)

  • Article
  • Open Access
2 Citations
2,160 Views
10 Pages

Preoperative Glycosylated Haemoglobin Screening to Identify Older Adult Patients with Undiagnosed Diabetes Mellitus—A Retrospective Cohort Study

  • Robert van Wilpe,
  • Mark L. van Zuylen,
  • Jeroen Hermanides,
  • J. Hans DeVries,
  • Benedikt Preckel and
  • Abraham H. Hulst

19 February 2024

More than 25% of older adults in Europe have diabetes mellitus. It is estimated that 45% of patients with diabetes are currently undiagnosed, which is a known risk factor for perioperative morbidity. We investigated whether routine HbA1c screening in...

  • Article
  • Open Access
2 Citations
2,988 Views
11 Pages

Non-Pharmacological Intervention for Personalizing Sleep Quality through Gentle Rocking Motion

  • Damiana-Maria Vulturar,
  • Liviu-Ștefan Moacă,
  • Ioana Maria Chețan,
  • Ștefan Cristian Vesa,
  • Teodora-Gabriela Alexescu,
  • Cristina Grigorescu,
  • Antigona Carmen Trofor,
  • Mirela-Anca Stoia,
  • Alexandra Floriana Nemes and
  • Doina-Adina Todea

19 February 2024

Introduction: Achieving restorative sleep is crucial for overall well-being, yet sleep difficulties affect a substantial portion of the adult population. Sleep disturbances are associated with diminished quality of life, physical complaints, cognitiv...

  • Review
  • Open Access
47 Citations
7,545 Views
50 Pages

Microbiome Dynamics: A Paradigm Shift in Combatting Infectious Diseases

  • Mohamed Kamel,
  • Sami Aleya,
  • Majed Alsubih and
  • Lotfi Aleya

18 February 2024

Infectious diseases have long posed a significant threat to global health and require constant innovation in treatment approaches. However, recent groundbreaking research has shed light on a previously overlooked player in the pathogenesis of disease...

  • Review
  • Open Access
4 Citations
2,594 Views
12 Pages

18 February 2024

Study design: Mechanical thrombectomy (MT) via the transbrachial approach (TBA) is a very rare option used in cases of patients with aortic pathologies and acute ischemic stroke (AIS) due to the insufficient evidence in the literature, the difficulty...

  • Article
  • Open Access
1 Citations
1,917 Views
10 Pages

Performance in Behavioral Testing in an Animal Model of Post-Surgical Hypoparathyroidism

  • Cristina Dettori,
  • Francesca Ronca,
  • Giulia Di Buono,
  • Alessandro Saba,
  • Francesca Di Lupo,
  • Beatrice Polini,
  • Caterina Ricardi,
  • Sabina Frascarelli,
  • Filomena Cetani and
  • Claudio Marcocci
  • + 4 authors

17 February 2024

Background: Hypoparathyroidism (HypoPT) is characterized by hypocalcemia and undetectable/inappropriately low PTH. Post-surgical HypoPT (PS-HypoPT) is the most common cause. Patients with PS-HypoPT present neuropsychological symptoms, probably due to...

  • Article
  • Open Access
13 Citations
4,813 Views
31 Pages

Assessing the Impact of Organ Failure and Metastases on Quality of Life in Breast Cancer Patients: A Prospective Study Based on Utilizing EORTC QLQ-C30 and EORTC QLQ-BR45 Questionnaires in Romania

  • Andreea-Iuliana Ionescu (Miron),
  • Alexandra-Valentina Anghel,
  • Ionuț-Lucian Antone-Iordache,
  • Dimitrie-Ionuț Atasiei,
  • Cătălin-Alexandru Anghel,
  • Andrei-Alexandru Barnonschi,
  • Alexandra-Maria Bobolocu,
  • Catinca Verga,
  • Florica Șandru and
  • Horia-Dan Lișcu

16 February 2024

Breast cancer (BC) significantly impacts the quality of life (QoL) of affected individuals. This study, conducted at Colțea Clinical Hospital, Bucharest, aimed to assess the impact of organ failures and metastases on QoL in breast cancer patient...

  • Article
  • Open Access
7 Citations
2,094 Views
11 Pages

Impacts of Neoadjuvant Chemotherapy on Perioperative Outcomes in Patients with Bladder Cancer Treated with Radical Cystectomy: A Single High-Volume Center Experience

  • Flavia Proietti,
  • Rocco Simone Flammia,
  • Leslie Claire Licari,
  • Eugenio Bologna,
  • Alfredo Maria Bove,
  • Aldo Brassetti,
  • Gabriele Tuderti,
  • Riccardo Mastroianni,
  • Antonio Tufano and
  • Giuseppe Simone
  • + 1 author

16 February 2024

(1) Background: Less than 30% of patients with muscle-invasive bladder cancer (MIBC) receive neoadjuvant chemotherapy (NAC), and reasons for underuse remain unclear. One potential explanation is the concern for the increased risk of perioperative mor...

  • Article
  • Open Access
1 Citations
2,155 Views
12 Pages

16 February 2024

Background: Coronary artery disease is caused by changes in the coronary arteries due to the atherosclerotic process and thrombotic changes. A very important role in the development of the atherosclerotic process in the coronary vessels is played by...

  • Article
  • Open Access
1 Citations
3,388 Views
18 Pages

16 February 2024

Introduction: Abdominal oncologic surgeries pose significant risks due to the complexity of the surgery and patients’ often weakened health, multiple comorbidities, and increased perioperative hazards. Hypotension is a major risk factor for per...

  • Brief Report
  • Open Access
2 Citations
3,002 Views
10 Pages

Performance of a Machine Learning Algorithm to Predict Hypotension in Spontaneously Breathing Non-Ventilated Post-Anesthesia and ICU Patients

  • Johan T. M. Tol,
  • Lotte E. Terwindt,
  • Santino R. Rellum,
  • Marije Wijnberge,
  • Björn J. P. van der Ster,
  • Eline Kho,
  • Markus W. Hollmann,
  • Alexander P. J. Vlaar,
  • Denise P. Veelo and
  • Jimmy Schenk

15 February 2024

Background: Hypotension is common in the post-anesthesia care unit (PACU) and intensive care unit (ICU), and is associated with adverse patient outcomes. The Hypotension Prediction Index (HPI) algorithm has been shown to accurately predict hypotensio...

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J. Pers. Med. - ISSN 2075-4426